In vitro to in vivo extrapolation for high throughput prioritization and decision making

In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses, i.e., in vitro to in vivo extrapolation (IVIVE). Curren...

Full description

Saved in:

Bibliographic Details
Published in	Toxicology in vitro Vol. 47; pp. 213 - 227
Main Authors	Bell, Shannon M., Chang, Xiaoqing, Wambaugh, John F., Allen, David G., Bartels, Mike, Brouwer, Kim L.R., Casey, Warren M., Choksi, Neepa, Ferguson, Stephen S., Fraczkiewicz, Grazyna, Jarabek, Annie M., Ke, Alice, Lumen, Annie, Lynn, Scott G., Paini, Alicia, Price, Paul S., Ring, Caroline, Simon, Ted W., Sipes, Nisha S., Sprankle, Catherine S., Strickland, Judy, Troutman, John, Wetmore, Barbara A., Kleinstreuer, Nicole C.
Format	Journal Article
Language	English
Published	England Elsevier Ltd 01.03.2018 Elsevier Science Ltd
Subjects	Animal Use Alternatives - trends Animals Assessments Biocompatibility Case studies Chemical Safety - instrumentation Chemical Safety - legislation & jurisprudence Chemical Safety - methods Chemical Safety - trends Computational Biology Computational toxicology Computer Simulation Decision making Decision Making, Computer-Assisted Decision Making, Organizational Environmental protection Expert Systems Extrapolation Guidelines as Topic Health Priorities - trends Health risks High throughput testing High-Throughput Screening Assays - trends Humans In vitro methods and tests In vivo methods and tests IVIVE Models, Biological National Institute of Environmental Health Sciences (U.S.) Organic chemistry R&D Research & development Risk assessment Safety System effectiveness Toxicity Toxicity testing Toxicity Tests - instrumentation Toxicity Tests - methods Toxicity Tests - trends Toxicokinetic Toxicology United States United States Dept. of Health and Human Services United States Environmental Protection Agency AOP ADME HTS IVIVE PBPK High throughput testing fu QSAR Computational toxicology Risk assessment TK Toxicity testing Toxicokinetic
Online Access	Get full text

Cover

Loading…

Abstract	In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses, i.e., in vitro to in vivo extrapolation (IVIVE). Currently available IVIVE approaches need to be refined before they can be utilized for regulatory decision-making. To explore the capabilities and limitations of IVIVE within this context, the U.S. Environmental Protection Agency Office of Research and Development and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods co-organized a workshop and webinar series. Here, we integrate content from the webinars and workshop to discuss activities and resources that would promote inclusion of IVIVE in regulatory decision-making. We discuss properties of models that successfully generate predictions of in vivo doses from effective in vitro concentration, including the experimental systems that provide input parameters for these models, areas of success, and areas for improvement to reduce model uncertainty. Finally, we provide case studies on the uses of IVIVE in safety assessments, which highlight the respective differences, information requirements, and outcomes across various approaches when applied for decision-making. •In vitro to in vivo extrapolation uses a model relating active in vitro concentrations to an in vivo response-inducing dose•Models for regulatory use will vary depending on needs: prioritization vs. hazard assessment•Transparency and reporting standards for models are critical during implementation
AbstractList	In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses, i.e., in vitro to in vivo extrapolation (IVIVE). Currently available IVIVE approaches need to be refined before they can be utilized for regulatory decision-making. To explore the capabilities and limitations of IVIVE within this context, the U.S. Environmental Protection Agency Office of Research and Development and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods co-organized a workshop and webinar series. Here, we integrate content from the webinars and workshop to discuss activities and resources that would promote inclusion of IVIVE in regulatory decision-making. We discuss properties of models that successfully generate predictions of in vivo doses from effective in vitro concentration, including the experimental systems that provide input parameters for these models, areas of success, and areas for improvement to reduce model uncertainty. Finally, we provide case studies on the uses of IVIVE in safety assessments, which highlight the respective differences, information requirements, and outcomes across various approaches when applied for decision-making.In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses, i.e., in vitro to in vivo extrapolation (IVIVE). Currently available IVIVE approaches need to be refined before they can be utilized for regulatory decision-making. To explore the capabilities and limitations of IVIVE within this context, the U.S. Environmental Protection Agency Office of Research and Development and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods co-organized a workshop and webinar series. Here, we integrate content from the webinars and workshop to discuss activities and resources that would promote inclusion of IVIVE in regulatory decision-making. We discuss properties of models that successfully generate predictions of in vivo doses from effective in vitro concentration, including the experimental systems that provide input parameters for these models, areas of success, and areas for improvement to reduce model uncertainty. Finally, we provide case studies on the uses of IVIVE in safety assessments, which highlight the respective differences, information requirements, and outcomes across various approaches when applied for decision-making. In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses, i.e., in vitro to in vivo extrapolation (IVIVE). Currently available IVIVE approaches need to be refined before they can be utilized for regulatory decision-making. To explore the capabilities and limitations of IVIVE within this context, the U.S. Environmental Protection Agency Office of Research and Development and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods co-organized a workshop and webinar series. Here, we integrate content from the webinars and workshop to discuss activities and resources that would promote inclusion of IVIVE in regulatory decision-making. We discuss properties of models that successfully generate predictions of in vivo doses from effective in vitro concentration, including the experimental systems that provide input parameters for these models, areas of success, and areas for improvement to reduce model uncertainty. Finally, we provide case studies on the uses of IVIVE in safety assessments, which highlight the respective differences, information requirements, and outcomes across various approaches when applied for decision-making. •In vitro to in vivo extrapolation uses a model relating active in vitro concentrations to an in vivo response-inducing dose•Models for regulatory use will vary depending on needs: prioritization vs. hazard assessment•Transparency and reporting standards for models are critical during implementation In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses, i.e., in vitro to in vivo extrapolation (IVIVE). Currently available IVIVE approaches need to be refined before they can be utilized for regulatory decision-making. To explore the capabilities and limitations of IVIVE within this context, the U.S. Environmental Protection Agency Office of Research and Development and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods co-organized a workshop and webinar series. Here, we integrate content from the webinars and workshop to discuss activities and resources that would promote inclusion of IVIVE in regulatory decision-making. We discuss properties of models that successfully generate predictions of in vivo doses from effective in vitro concentration, including the experimental systems that provide input parameters for these models, areas of success, and areas for improvement to reduce model uncertainty. Finally, we provide case studies on the uses of IVIVE in safety assessments, which highlight the respective differences, information requirements, and outcomes across various approaches when applied for decision-making.
Author	Brouwer, Kim L.R. Lumen, Annie Sprankle, Catherine S. Allen, David G. Ring, Caroline Wetmore, Barbara A. Ke, Alice Price, Paul S. Chang, Xiaoqing Choksi, Neepa Strickland, Judy Simon, Ted W. Casey, Warren M. Fraczkiewicz, Grazyna Kleinstreuer, Nicole C. Bartels, Mike Ferguson, Stephen S. Bell, Shannon M. Lynn, Scott G. Troutman, John Wambaugh, John F. Paini, Alicia Sipes, Nisha S. Jarabek, Annie M.
AuthorAffiliation	g Simulations Plus, Inc., 42505 10 th St. West, Lancaster, CA 93534, USA e National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA h Simcyp Limited (a Certara company), John Street, Sheffield S2 4SU, United Kingdom b U.S. Environmental Protection Agency, 109 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA f National Toxicology Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA c Dow Chemical Company, Saginaw, MI , USA d UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Campus Box 7569, Chapel Hill, NC 27599, USA m Ted Simon LLC, 4184 Johnston Road, Winston, GA 30187, USA a Integrated Laboratory Systems, Inc., P.O. Box 13501, Research Triangle Park, NC 27709, USA n Central Product Safety, The Procter & Gamble Company, Cincinnati, OH 45202
AuthorAffiliation_xml	– name: k European Commission, Joint Research Centre, Directorate Health, Consumers and Reference Materials, Chemical Safety and Alternative Methods Unit incorporating EURL ECVAM, Via E. Fermi 2749, Ispra, Varese 20127, Italy – name: n Central Product Safety, The Procter & Gamble Company, Cincinnati, OH 45202, USA – name: l Oak Ridge Institute for Science and Education, P.O. Box 2008, Oak Ridge, TN 37831, USA – name: i National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA – name: b U.S. Environmental Protection Agency, 109 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA – name: g Simulations Plus, Inc., 42505 10 th St. West, Lancaster, CA 93534, USA – name: f National Toxicology Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA – name: o ScitoVation LLC, 6 Davis Drive, Research Triangle Park, NC 27709, USA – name: a Integrated Laboratory Systems, Inc., P.O. Box 13501, Research Triangle Park, NC 27709, USA – name: c Dow Chemical Company, Saginaw, MI , USA – name: d UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Campus Box 7569, Chapel Hill, NC 27599, USA – name: e National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA – name: j U.S. Environmental Protection Agency, William Jefferson Clinton Building, 1200 Pennsylvania Ave. NW, Washington, DC 20460, USA – name: h Simcyp Limited (a Certara company), John Street, Sheffield S2 4SU, United Kingdom – name: m Ted Simon LLC, 4184 Johnston Road, Winston, GA 30187, USA
Author_xml	– sequence: 1 givenname: Shannon M. surname: Bell fullname: Bell, Shannon M. email: SBell@ils-inc.com organization: Integrated Laboratory Systems, Inc., P.O. Box 13501, Research Triangle Park, NC 27709, USA – sequence: 2 givenname: Xiaoqing surname: Chang fullname: Chang, Xiaoqing email: XChang@ils-inc.com organization: Integrated Laboratory Systems, Inc., P.O. Box 13501, Research Triangle Park, NC 27709, USA – sequence: 3 givenname: John F. orcidid: 0000-0002-4024-534X surname: Wambaugh fullname: Wambaugh, John F. email: wambaugh.john@epa.gov organization: U.S. Environmental Protection Agency, 109 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA – sequence: 4 givenname: David G. surname: Allen fullname: Allen, David G. email: DAllen@ils-inc.com organization: Integrated Laboratory Systems, Inc., P.O. Box 13501, Research Triangle Park, NC 27709, USA – sequence: 5 givenname: Mike surname: Bartels fullname: Bartels, Mike email: mjbartels@toxmetrics.com organization: Dow Chemical Company, Saginaw, MI 48603, USA – sequence: 6 givenname: Kim L.R. surname: Brouwer fullname: Brouwer, Kim L.R. email: kbrouwer@unc.edu organization: UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Campus Box 7569, Chapel Hill, NC 27599, USA – sequence: 7 givenname: Warren M. surname: Casey fullname: Casey, Warren M. email: warren.casey@nih.gov organization: National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA – sequence: 8 givenname: Neepa surname: Choksi fullname: Choksi, Neepa email: NChoksi@ils-inc.com organization: Integrated Laboratory Systems, Inc., P.O. Box 13501, Research Triangle Park, NC 27709, USA – sequence: 9 givenname: Stephen S. surname: Ferguson fullname: Ferguson, Stephen S. email: Stephen.ferguson@nih.gov organization: National Toxicology Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA – sequence: 10 givenname: Grazyna surname: Fraczkiewicz fullname: Fraczkiewicz, Grazyna email: grace@simulations-plus.com organization: Simulations Plus, Inc., 42505 10th St. West, Lancaster, CA 93534, USA – sequence: 11 givenname: Annie M. surname: Jarabek fullname: Jarabek, Annie M. email: jarabek.annie@epa.gov organization: U.S. Environmental Protection Agency, 109 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA – sequence: 12 givenname: Alice surname: Ke fullname: Ke, Alice email: alice.ke@certara.com organization: Simcyp Limited (a Certara company), John Street, Sheffield, S2 4SU, United Kingdom – sequence: 13 givenname: Annie surname: Lumen fullname: Lumen, Annie email: annie.lumen@fda.hhs.gov organization: National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA – sequence: 14 givenname: Scott G. surname: Lynn fullname: Lynn, Scott G. email: lynn.scott@epa.gov organization: U.S. Environmental Protection Agency, William Jefferson Clinton Building, 1200 Pennsylvania Ave. NW, Washington, DC 20460, USA – sequence: 15 givenname: Alicia surname: Paini fullname: Paini, Alicia email: Alicia.paini@ec.europa.eu organization: European Commission, Joint Research Centre, Directorate Health, Consumers and Reference Materials, Chemical Safety and Alternative Methods Unit incorporating EURL ECVAM, Via E. Fermi 2749, Ispra, Varese 20127, Italy – sequence: 16 givenname: Paul S. surname: Price fullname: Price, Paul S. email: price.pauls@epa.gov organization: U.S. Environmental Protection Agency, 109 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA – sequence: 17 givenname: Caroline surname: Ring fullname: Ring, Caroline email: cring@toxstrategies.com organization: Oak Ridge Institute for Science and Education, P.O. Box 2008, Oak Ridge, TN 37831, USA – sequence: 18 givenname: Ted W. surname: Simon fullname: Simon, Ted W. email: ted@tedsimon-toxicology.com organization: Ted Simon LLC, 4184 Johnston Road, Winston, GA 30187, USA – sequence: 19 givenname: Nisha S. surname: Sipes fullname: Sipes, Nisha S. email: Nisha.sipes@nih.gov organization: National Toxicology Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA – sequence: 20 givenname: Catherine S. orcidid: 0000-0001-9436-5673 surname: Sprankle fullname: Sprankle, Catherine S. email: CSprankle@ils-inc.com organization: Integrated Laboratory Systems, Inc., P.O. Box 13501, Research Triangle Park, NC 27709, USA – sequence: 21 givenname: Judy surname: Strickland fullname: Strickland, Judy email: JStrickland@ils-inc.com organization: Integrated Laboratory Systems, Inc., P.O. Box 13501, Research Triangle Park, NC 27709, USA – sequence: 22 givenname: John surname: Troutman fullname: Troutman, John email: troutman.ja@pg.com organization: Central Product Safety, The Procter & Gamble Company, Cincinnati, OH 45202, USA – sequence: 23 givenname: Barbara A. surname: Wetmore fullname: Wetmore, Barbara A. email: Wetmore.barbara@epa.gov organization: ScitoVation LLC, 6 Davis Drive, Research Triangle Park, NC 27709, USA – sequence: 24 givenname: Nicole C. surname: Kleinstreuer fullname: Kleinstreuer, Nicole C. email: nicole.kleinstreuer@nih.gov organization: National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29203341$$D View this record in MEDLINE/PubMed
BookMark	eNp9kUFv1DAQhS1URLeFH8AFWeLCJcFjJ3EiJKSqKlCpEheQuFlex9nMkrUX24mAX18vWyrooSfb4--N3sw7IyfOO0vIS2AlMGjebsuES8kZyBKgzJUnZAWt7AoBUp6QFWtbWXAhxCk5i3HLGKtbzp6RU95xJkQFK_Lt2tEFU_A0eYqH--Kp_ZmC3vtJJ_SODj7QETcjTWPw82bcz4nuA_qACX8fEe162luD8fDY6e_oNs_J00FP0b64O8_J1w9XXy4_FTefP15fXtwUpq7qVFRdJzn0FZdW1kyDMFpnd8K0g5a1GNadltBqkMxkomF6WLM8cGM6adaiacQ5eX_su5_XO9sb67L3SWWDOx1-Ka9R_f_jcFQbvygpOtF0Ijd4c9cg-B-zjUntMBo7TdpZP0cFnRSM13mXGX39AN36Obg8nuKskaKpq4pl6tW_ju6t_F16BuAImOBjDHa4R4CpQ7Bqq3Kw6hCsAlC5kjXygcZg-rP8PBROjyrfHZU2p7CgDSoatM7YHoM1SfUeH1HfAqNUvhQ
CitedBy_id	crossref_primary_10_3390_toxics11020098 crossref_primary_10_1016_j_envint_2023_108411 crossref_primary_10_1016_j_jhazmat_2022_128658 crossref_primary_10_1016_j_envint_2023_108097 crossref_primary_10_1093_toxsci_kfaa007 crossref_primary_10_1038_s41597_020_0455_1 crossref_primary_10_2903_sp_efsa_2020_EN_1938 crossref_primary_10_1002_bdr2_2019 crossref_primary_10_1016_j_envint_2024_109229 crossref_primary_10_1016_j_fct_2020_111313 crossref_primary_10_1016_j_taap_2022_116141 crossref_primary_10_1016_j_taap_2019_114635 crossref_primary_10_1016_j_crtox_2025_100228 crossref_primary_10_3390_ijerph17062124 crossref_primary_10_1016_j_cotox_2019_02_003 crossref_primary_10_1016_j_ejmech_2025_117368 crossref_primary_10_1186_s12302_018_0151_3 crossref_primary_10_1016_j_crtox_2022_100064 crossref_primary_10_1016_j_fct_2018_09_055 crossref_primary_10_1021_acssuschemeng_7b04220 crossref_primary_10_1016_j_fct_2024_114789 crossref_primary_10_1021_acs_chemrestox_9b00484 crossref_primary_10_1007_s00216_023_04781_w crossref_primary_10_1016_j_tiv_2023_105664 crossref_primary_10_1007_s00204_020_02766_7 crossref_primary_10_1016_j_tiv_2019_06_006 crossref_primary_10_1016_j_compbiolchem_2018_06_005 crossref_primary_10_1016_j_taap_2023_116659 crossref_primary_10_1016_j_tibtech_2019_04_009 crossref_primary_10_1016_j_fct_2023_114022 crossref_primary_10_1016_j_ecoenv_2020_111628 crossref_primary_10_1016_j_envint_2021_106760 crossref_primary_10_1016_j_envint_2023_107857 crossref_primary_10_3389_ftox_2021_787756 crossref_primary_10_1016_j_drudis_2020_11_037 crossref_primary_10_1002_etc_4315 crossref_primary_10_3390_brainsci13020252 crossref_primary_10_1016_j_tox_2023_153708 crossref_primary_10_1093_toxsci_kfae037 crossref_primary_10_2131_jts_45_763 crossref_primary_10_3390_toxics12080541 crossref_primary_10_1016_j_tiv_2019_104684 crossref_primary_10_1016_j_tiv_2020_104916 crossref_primary_10_1093_toxsci_kfac018 crossref_primary_10_1016_j_watres_2022_118878 crossref_primary_10_3389_ftox_2024_1376118 crossref_primary_10_1016_j_aquaculture_2024_741695 crossref_primary_10_1016_j_scitotenv_2023_165271 crossref_primary_10_1002_bdr2_2395 crossref_primary_10_1016_j_envint_2022_107547 crossref_primary_10_1021_acs_est_0c06117 crossref_primary_10_1093_toxsci_kfy020 crossref_primary_10_1016_j_jhazmat_2020_122856 crossref_primary_10_1093_toxsci_kfae079 crossref_primary_10_1248_bpb_b23_00358 crossref_primary_10_3389_fphar_2022_879907 crossref_primary_10_1007_s00204_024_03800_8 crossref_primary_10_1016_j_comtox_2020_100147 crossref_primary_10_1007_s00204_022_03356_5 crossref_primary_10_1016_j_tiv_2018_06_009 crossref_primary_10_1248_bpb_b22_00502 crossref_primary_10_1016_j_tox_2022_153340 crossref_primary_10_1002_smll_202006252 crossref_primary_10_1016_j_fct_2018_09_061 crossref_primary_10_1007_s00204_019_02613_4 crossref_primary_10_1007_s00204_023_03485_5 crossref_primary_10_1016_j_toxrep_2020_01_004 crossref_primary_10_1038_s41370_022_00492_z crossref_primary_10_2139_ssrn_4123443 crossref_primary_10_1021_acs_est_1c07143 crossref_primary_10_1007_s00204_020_02802_6 crossref_primary_10_1016_j_ecoenv_2024_115976 crossref_primary_10_1016_j_yrtph_2019_01_016 crossref_primary_10_3390_toxics12110811 crossref_primary_10_1016_j_chemosphere_2022_135929 crossref_primary_10_1093_toxsci_kfad012 crossref_primary_10_1093_toxsci_kfab076 crossref_primary_10_1126_science_adq0336 crossref_primary_10_3389_ftox_2023_1292373 crossref_primary_10_1021_acs_chemrestox_0c00336 crossref_primary_10_1039_d0mt00071j crossref_primary_10_1016_j_comtox_2020_100136 crossref_primary_10_29121_granthaalayah_v7_i3_2019_958 crossref_primary_10_3389_fbioe_2018_00120 crossref_primary_10_3390_ph17111449 crossref_primary_10_1248_bpb_b21_00769 crossref_primary_10_1016_j_envres_2023_117343 crossref_primary_10_1016_j_toxlet_2020_11_016 crossref_primary_10_1093_toxsci_kfz216 crossref_primary_10_1016_j_reprotox_2022_09_004 crossref_primary_10_1016_j_taap_2018_04_001 crossref_primary_10_1016_j_yrtph_2020_104667 crossref_primary_10_1360_TB_2023_0351 crossref_primary_10_1021_envhealth_4c00043 crossref_primary_10_1016_j_emcon_2023_100296 crossref_primary_10_1016_j_comtox_2022_100241 crossref_primary_10_5487_TR_2019_35_4_295 crossref_primary_10_1093_nar_gkac1074 crossref_primary_10_3389_fonc_2023_1167082 crossref_primary_10_1016_j_tiv_2018_12_017 crossref_primary_10_1093_toxsci_kfz205 crossref_primary_10_1016_j_yrtph_2024_105596 crossref_primary_10_1038_s41370_018_0046_9 crossref_primary_10_1039_D2NR00664B crossref_primary_10_1093_toxsci_kfz201 crossref_primary_10_1016_j_tiv_2025_106036 crossref_primary_10_1021_acs_estlett_4c00393 crossref_primary_10_1016_j_yrtph_2022_105117 crossref_primary_10_1016_j_yrtph_2022_105238 crossref_primary_10_1371_journal_pone_0244070 crossref_primary_10_1016_j_envint_2021_106566 crossref_primary_10_1016_j_comtox_2018_11_002 crossref_primary_10_1016_j_cotox_2019_05_005 crossref_primary_10_1016_j_chemosphere_2019_01_062 crossref_primary_10_1080_10408444_2021_1953439 crossref_primary_10_1016_j_envres_2021_112225 crossref_primary_10_1016_j_yrtph_2020_104661 crossref_primary_10_1021_acs_est_3c08314 crossref_primary_10_1016_j_comtox_2019_03_001 crossref_primary_10_3389_ftox_2024_1373325 crossref_primary_10_1016_j_comtox_2018_07_002 crossref_primary_10_1016_j_chemosphere_2024_143408 crossref_primary_10_3390_ijms23095018 crossref_primary_10_1016_j_comtox_2019_100111 crossref_primary_10_3389_fphar_2021_754408 crossref_primary_10_3390_toxics10050232 crossref_primary_10_1002_dta_3344 crossref_primary_10_1002_jat_4223 crossref_primary_10_1016_j_taap_2021_115678 crossref_primary_10_1021_acs_chemrestox_0c00092 crossref_primary_10_1016_j_chemosphere_2023_140159 crossref_primary_10_2903_sp_efsa_2022_EN_7341 crossref_primary_10_1016_j_yrtph_2020_104724 crossref_primary_10_1016_j_chemosphere_2024_143020 crossref_primary_10_1093_toxsci_kfaa067 crossref_primary_10_1002_etc_5578 crossref_primary_10_1021_acsestwater_3c00152 crossref_primary_10_1080_19390211_2024_2417679 crossref_primary_10_3389_ftox_2023_1051483 crossref_primary_10_1016_j_comtox_2021_100184 crossref_primary_10_1021_acs_chemrestox_0c00009 crossref_primary_10_1002_ps_5577 crossref_primary_10_1016_j_bcp_2021_114468 crossref_primary_10_1021_acs_est_9b03266 crossref_primary_10_1080_17425255_2021_1935867 crossref_primary_10_1124_dmd_118_082024 crossref_primary_10_1080_10807039_2023_2258985 crossref_primary_10_1016_j_bcp_2021_114749 crossref_primary_10_1016_j_heliyon_2023_e17575 crossref_primary_10_3390_ijerph182312469 crossref_primary_10_1007_s11626_021_00548_8 crossref_primary_10_1016_j_yrtph_2018_09_008 crossref_primary_10_1186_s40246_024_00691_9 crossref_primary_10_1016_j_envint_2022_107458 crossref_primary_10_1039_C8TX00338F crossref_primary_10_1016_j_scitotenv_2024_176003 crossref_primary_10_3390_cells13242057 crossref_primary_10_1016_j_jaerosci_2021_105755 crossref_primary_10_1016_j_tox_2023_153684 crossref_primary_10_1021_acs_chemrestox_1c00249 crossref_primary_10_3389_ftox_2024_1352783 crossref_primary_10_1002_etc_5584 crossref_primary_10_3389_ftox_2022_911128 crossref_primary_10_1016_j_comtox_2019_100092 crossref_primary_10_2478_acph_2021_0001 crossref_primary_10_1016_j_tiv_2021_105090 crossref_primary_10_3389_ftox_2024_1368320 crossref_primary_10_1002_jat_4617 crossref_primary_10_1016_j_ntt_2020_106902 crossref_primary_10_1021_acs_chemrestox_8b00307 crossref_primary_10_1096_fj_201902143R
Cites_doi	10.1016/j.envint.2017.06.004 10.1124/dmd.116.069831 10.1093/toxsci/kfm100 10.1093/toxsci/kfu200 10.3389/fphar.2014.00240 10.1124/jpet.114.221564 10.1517/17425250802691074 10.1016/0887-2333(95)00084-4 10.1007/978-1-62703-050-2_18 10.1016/j.envres.2015.09.013 10.1177/026119291604400517 10.1093/toxsci/kfw119 10.1038/clpt.2013.78 10.1289/ehp.1409450 10.1021/es503583j 10.1093/toxsci/kfp217 10.1038/clpt.2013.81 10.1021/mp9001574 10.1006/taap.1998.8485 10.1002/cpt1975184377 10.1002/jps.10462 10.1021/es102150z 10.1021/tx3000939 10.1002/bdrc.20223 10.2133/dmpk.DMPK-11-RV-090 10.1021/mp8002495 10.1016/S0090-9556(24)15299-3 10.1039/c3lc50197c 10.1093/toxsci/kfu169 10.3109/10408449709089895 10.1111/j.0272-4332.2004.00561.x 10.1021/tx100428e 10.3109/03602530903491881 10.1089/aivt.2014.0005 10.1016/j.tiv.2007.09.010 10.1289/ehp.1205784 10.1016/j.toxlet.2014.03.013 10.1289/ehp.1510183 10.1016/j.yrtph.2016.01.007 10.1124/dmd.107.018200 10.1093/toxsci/kfw193 10.1016/j.tiv.2013.10.023 10.1016/S0045-6535(99)00279-9 10.1021/acs.est.5b00176 10.1124/dmd.110.032177 10.1007/s11095-013-1023-6 10.1002/jbt.20179 10.1289/ehp.1103412 10.1016/j.taap.2016.10.026 10.1016/j.tox.2013.08.012 10.1093/toxsci/kfr254 10.1016/S0166-445X(00)00117-X 10.1111/j.1365-2885.2012.01419.x 10.1016/j.tox.2016.05.026 10.1038/ng1201-365 10.1208/s12248-008-9019-6 10.1016/j.fct.2014.10.017 10.1038/sj.jes.7500540 10.1021/es404301q 10.1016/j.tox.2013.08.010 10.1002/etc.3456 10.1023/B:MODI.0000047512.82293.75 10.1208/s12248-009-9107-2 10.1007/s00204-011-0768-0 10.1517/17425255.2015.979152 10.1016/j.taap.2007.12.037 10.1016/j.yrtph.2015.02.011 10.1289/ehp.1306638 10.1093/toxsci/kfu199 10.1093/toxsci/kfr295 10.1016/S0147-6513(02)00040-4 10.1093/toxsci/kft178 10.1016/S0048-9697(01)00743-4 10.1093/toxsci/kfv171 10.1002/psp4.33 10.3389/fphar.2011.00056 10.1016/j.tiv.2015.09.005 10.1016/j.ejps.2015.06.023 10.1021/es501955g 10.1002/etc.2504 10.1093/toxsci/kft078 10.1038/clpt.2014.158 10.1056/NEJMra035092 10.1016/j.tiv.2012.06.012 10.1016/j.tiv.2016.07.013 10.1177/009286159502900312 10.1007/s40262-014-0140-7 10.1007/s11095-015-1749-4 10.1038/srep25187 10.1002/jps.23262 10.1208/s12248-009-9103-6 10.1016/j.compbiomed.2004.02.008 10.1093/ilar.45.4.469 10.1146/annurev-pharmtox-010510-100540 10.1002/etc.5620130721 10.1080/10937404.2010.483940 10.1093/toxsci/kfw082 10.1002/jps.23202 10.1093/toxsci/kfq220 10.1038/sj.clpt.6100059 10.1093/bioinformatics/btw680 10.1016/0041-008X(90)90338-U 10.1016/j.reprotox.2015.01.002 10.1093/toxsci/kfv118 10.1016/j.taap.2010.09.010 10.1186/2193-9616-1-10 10.3389/fphar.2015.00107 10.1093/toxsci/kfh239 10.1016/j.tiv.2017.03.004 10.1021/acs.chemrestox.7b00023 10.1021/acs.est.5b05311
ContentType	Journal Article
Copyright	2017 Published by Elsevier Ltd. Copyright Elsevier Science Ltd. Mar 2018
Copyright_xml	– notice: 2017 – notice: Published by Elsevier Ltd. – notice: Copyright Elsevier Science Ltd. Mar 2018
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7TK 7U7 C1K 7X8 5PM
DOI	10.1016/j.tiv.2017.11.016
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts Toxicology Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Toxicology Abstracts Neurosciences Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic Toxicology Abstracts MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Chemistry Public Health Pharmacy, Therapeutics, & Pharmacology
EISSN	1879-3177
EndPage	227
ExternalDocumentID	PMC7393693 29203341 10_1016_j_tiv_2017_11_016 S0887233317303661
Genre	Journal Article Review
GrantInformation_xml	– fundername: NIGMS NIH HHS grantid: R01 GM041935 – fundername: NIGMS NIH HHS grantid: R35 GM122576 – fundername: NIEHS NIH HHS grantid: HHSN273201500010C – fundername: Intramural NIH HHS grantid: Z99 ES999999
GroupedDBID	--- --K --M .~1 0R~ 123 1B1 1RT 1~. 1~5 29Q 4.4 457 4G. 53G 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABFRF ABFYP ABJNI ABLST ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLECG BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IHE J1W KCYFY KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SDF SDG SDP SES SEW SPCBC SPT SSJ SSP SSZ T5K UNMZH WUQ ZXP ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH CGR CUY CVF ECM EFKBS EIF NPM 7TK 7U7 C1K 7X8 5PM
ID	FETCH-LOGICAL-c545t-499721d427e750a13caa2923c8fa753fb9a718a170c7e760afb02016c97cb3663
IEDL.DBID	.~1
ISSN	0887-2333 1879-3177
IngestDate	Thu Aug 21 14:13:56 EDT 2025 Tue Aug 05 10:05:47 EDT 2025 Sat Jul 26 02:25:12 EDT 2025 Mon Jul 21 06:04:10 EDT 2025 Thu Jul 03 08:44:20 EDT 2025 Thu Apr 24 23:01:36 EDT 2025 Fri Feb 23 02:30:46 EST 2024
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	AOP ADME HTS IVIVE PBPK High throughput testing fu QSAR Computational toxicology Risk assessment TK Toxicity testing Toxicokinetic
Language	English
License	Published by Elsevier Ltd.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c545t-499721d427e750a13caa2923c8fa753fb9a718a170c7e760afb02016c97cb3663
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 U.S. Environmental Protection Agency, 109 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA. Wetmore.barbara@epa.gov. ToxStrategies, Austin, TX (78759), USA. cring@toxstrategies.com. http://ToxMetrics.com, 2407 Wilmington Drive, Midland, MI 48642 USA. mjbartels@toxmetrics.com.
ORCID	0000-0001-9436-5673 0000-0002-4024-534X
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/7393693
PMID	29203341
PQID	2067365440
PQPubID	2047453
PageCount	15
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_7393693 proquest_miscellaneous_1973025088 proquest_journals_2067365440 pubmed_primary_29203341 crossref_primary_10_1016_j_tiv_2017_11_016 crossref_citationtrail_10_1016_j_tiv_2017_11_016 elsevier_sciencedirect_doi_10_1016_j_tiv_2017_11_016
PublicationCentury	2000
PublicationDate	2018-03-01
PublicationDateYYYYMMDD	2018-03-01
PublicationDate_xml	– month: 03 year: 2018 text: 2018-03-01 day: 01
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England – name: Oxford
PublicationTitle	Toxicology in vitro
PublicationTitleAlternate	Toxicol In Vitro
PublicationYear	2018
Publisher	Elsevier Ltd Elsevier Science Ltd
Publisher_xml	– name: Elsevier Ltd – name: Elsevier Science Ltd
References	Ring, Pearce, Setzer, Wetmore, Wambaugh (bb0520) 2017; 106 Votano, Parham, Hall, Kier (bb0640) 2004; 8 Wetmore, Wambaugh, Allen, Ferguson, Sochaski, Setzer, Houck, Strope, Cantwell, Judson, LeCluyse, Clewell, Thomas, Andersen (bb0680) 2015; 148 Péry, Devillers, Brochot, Mombelli, Palluel, Piccini, Brion, Beaudouin (bb0500) 2014; 48 Rotroff, Wetmore, Dix, Ferguson, Clewell, Houck, Lecluyse, Andersen, Judson, Smith, Sochaski, Kavlock, Boellmann, Martin, Reif, Wambaugh, Thomas (bb0525) 2010; 117 Tice, Austin, Kavlock, Bucher (bb0600) 2013; 121 Wambaugh, Wetmore, Pearce, Strope, Goldsmith, Sluka, Sedykh, Tropsha, Bosgra, Shah, Judson, Thomas, Setzer (bb0655) 2015; 147 EPA (bb0165) 2017 Clark, Setzer, Barton (bb0110) 2004; 24 EPA (bb0175) 2017 Yang, Woodhead, Watkins, Howell, Brouwer (bb0705) 2014; 96 Lee, No, Kang, Ju, Kim, Lee (bb0350) 2013; 13 Perkins, Ankley, Crofton, Garcia-Reyero, LaLone, Johnson, Tietge, Villeneuve (bb0495) 2013; 121 U.S. Food and Drug Administration (bb0620) 2017 Li, Singh, Mandrell, Lai (bb0360) 2010; 7 Rowland, Peck, Tucker (bb0530) 2011; 51 Swiss Institute of Bioinformatics (bb0580) 2013 Zhu, Sedykh, Zhu, Liu, Tropsha (bb0730) 2013; 30 European Union (bb0180) 2009; 309 COSMOS (bb0120) 2017 Fouchécourt, Béliveau, Krishnan (bb0205) 2001; 274 NIEHS (bb0445) 2017 Yang, Sun, Sun, Shan, Zhao, Zeng, Zeng (bb0700) 2013; 36 Bow, Perry, Miller, Pritchard, Brouwer (bb0050) 2008; 36 El-Masri, Kleinstreuer, Hines, Adams, Tal, Isaacs, Wetmore, Tan (bb0140) 2016; 152 Wetmore, Allen, Clewell, Parker, Wambaugh, Almond, Sochaski, Thomas (bb0675) 2014; 142 Parrott, Lave (bb0475) 2016 Sala Benito, Paini, Richarz, Meinl, Berthold, Cronin, Worth (bb0535) 2017 Kleinstreuer, Sullivan, Allen, Edwards, Mendrick, Embry, Matheson, Rowlands, Munn, Maull, Casey (bb0325) 2016; 76 Bujard, Voirol, Carrupt, Schappler (bb0070) 2015; 77 Alves, Muratov, Zakharov, Muratov, Andrage, Tropsha (bb0005) 2017 Wang (bb0660) 2010; 38 Thomas, Philbert, Auerbach, Wetmore, Devito, Cote, Rowlands, Whelan, Hays, Andersen, Meek, Reiter, Lambert, Clewell, Stephens, Zhao, Wesselkamper, Flowers, Carney, Pastoor, Petersen, Yauk, Nong (bb0595) 2013; 136 Kearns, Abdel-Rahman, Alander, Blowey, Leeder, Kauffman (bb0310) 2003; 349 Liu, Chism, LeCluyse, Brouwer, Brouwer (bb0380) 1999; 27 Salem, Johnson, Abduljalil, Tucker, Rostami-Hodjegan (bb0540) 2014; 53 Watanabe, Jensen, Orlando, Ankley (bb0665) 2007; 146 Yoon, Efremenko, Blaauboer, Clewell (bb0720) 2014; 28 Knudsen, Kleinstreuer (bb0330) 2011; 93 Armitage, Wania, Arnot (bb0020) 2014; 48 Bois, Diaz, Gjewska, Kovarich, Mauch, Paini, Pery, Sala Benito, Teng, Worth (bb0045) 2017; 392 EPA (bb0170) 2017 EPA (bb0160) 2016 OECD (bb0460) 2016 Lien, Nichols, McKim, Gallinat (bb0365) 1994; 13 Patlewicz, Simon, Rowlands, Budinsky, Becker (bb0480) 2015; 71 Nichols, McKim, Andersen, Gargas, Clewell, Erickson (bb0440) 1990; 106 Casey, Jacobs, Maull, Matheson, Clarke, Lowit (bb0085) 2015; 54 Parhizgari, Li (bb0470) 2014; 33 Pearce, Setzer, Strope, Sipes, Wambaugh (bb0485) 2017; 79 U.S. Fish and Wildlife Service (bb0615) 2015 Yang, Pfeifer, Köck, Brouwer (bb0710) 2015; 353 Filer, Kothiya, Setzer, Judson, Martin (bb0195) 2017; 33 Peyret, Poulin, Krishnan (bb0505) 2010; 249 Villeneuve, Crump, Garcia-Reyero, Hecker, Hutchinson, LaLone, Landesmann, Lettieri, Munn, Nepelska, Ottinger, Vergauwen, Whelan (bb0635) 2014; 142 Kramer, Di Consiglio, Blaauboer, Testai (bb0335) 2015; 30 Caldwell, Evans, Krishnan (bb0075) 2012; 2012 Lumen, George (bb0395) 2017; 314 Swift, Pfeifer, Brouwer (bb0575) 2010; 42 Harper, Brassil (bb0250) 2008; 10 Dansirikul, Choi, Duffull (bb0135) 2005; 35 Horton, Blout, Valentin-Blasini, Wapner, Whyatt, Gennings, Factor-Litvak (bb0270) 2015; 143 Wagner, Zhao, Pan, Hsu, Grillo, Huang, Sinha (bb0645) 2015; 4 Kleinstreuer, Ceger, Allen, Strickland, Chang, Hamm, Casey (bb0320) 2016; 124 Barton, Chiu, Woodrow, Andersen, Bailer, Bois, DeWoskin, Hays, Johanson, Jones, Loizou, MacPhail, Portier, Spendiff, Tan (bb0025) 2007; 99 Slob, Janssen, van den Hof (bb0555) 1997; 27 Dancik, Troutman, Jaworska (bb0125) 2013; 1 Fischer, Henneberger, König, Bittermann, Linden, Goss, Escher (bb0200) 2017; 30 Wambaugh, Wang, Dionisio, Frame, Egeghy, Judson, Setzer (bb0650) 2014; 48 McNally, Cotton, Loizou (bb0415) 2011; 2 NTP (bb0455) 2017 Tan, Liao, Clewell (bb0585) 2007; 17 Lipscomb, Fisher, Confer, Byczkowski (bb0375) 1998; 152 Brouwer, Keppler, Hoffmaster, Bow, Cheng, Lai, Palm, Stieger, Evers, International Transporter Consortium (bb0060) 2013; 94 Judson, Kavlock, Setzer, Hubal, Martin, Knudsen, Houck, Thomas, Wetmore, Dix (bb0300) 2011; 24 Sullivan (bb0570) 2016; 44 Wetmore, Wambaugh, Ferguson, Sochaski, Rotroff, Freeman, Clewell, Dix, Andersen, Houck, Allen, Judson, Singh, Kavlock, Richard, Thomas (bb0670) 2012; 125 Yoon, Kedderis, Yang, Allen, Yan, Clewell (bb0715) 2012 Chiba, Ishii, Sugiyama (bb0100) 2009; 11 Hines, Sargent, Autrup, Birnbaum, Brent, Doerrer, Cohen Hubal, Juberg, Laurent, Luebke, Olejniczak, Portier, Slikker (bb0260) 2010; 113 Ankley, Johnson (bb0010) 2004; 45 Mundy, Freudenrich, Crofton, DeVito (bb0420) 2004; 82 Frazier (bb0210) 1995; 9 Tonnelier, Coecke, Zaldívar (bb0610) 2012; 86 Dancik, Troutman, Jaworska (bb0130) 2015; 55 Fujiwara, Yamashita, Hashida (bb0215) 2003; 92 Hiratsuka (bb0265) 2012; 27 Lumen, McNally, George, Fisher, Loizou (bb0405) 2015; 6 Gajewska, Paini, Sala Benito, Burton, Worth, Urani, Briesen, Schramm (bb0225) 2015; 75 Ferguson, Bonzo (bb0190) 2014 EPA (bb0145) 2015; 80 Hallifax, Houston (bb0245) 2012; 101 Groothuis, Heringa, Nicol, Hermens, Blaauboer, Kramer (bb0235) 2015; 332 Bell, Hendriks, Moro, Ellis, Walsh, Renblom, Fredriksson Puigvert, Dankers, Jacobs, Snoeys, Sison-Young, Jenkins, Nordling, Mkrtchian, Park, Kitteringham, Goldring, Lauschke, Ingelman-Sundberg (bb0030) 2016; 6 Campbell, Clewell, Gentry, Andersen, Clewell (bb0080) 2012; 929 McLanahan, El-Masri, Sweeney, Kopylev, Clewell, Wambaugh, Schlosser (bb0410) 2012; 126 Schmitt (bb0545) 2008; 22 Wilkinson, Shand (bb0685) 1975; 18 Loizou, Hogg (bb0385) 2011; 2 LaLone, Villeneuve, Lyons, Helgen, Robinson, Swintek, Saari, Ankley (bb0340) 2016; 153 Chu, Korzekwa, Elsby, Fenner, Galetin, Lai, Matsson, Moss, Nagar, Rosania, Bai, Polli, Sugiyama, Brouwer, International Transporter Consortium (bb0105) 2013; 94 European Union (bb0185) 2012; 167 Lawless, DiBella, Bolger, Clark, Huehn, Waldman, Zhang, Lukacova (bb0345) 2015 Brazma, Hingamp, Quackenbush, Sherlock, Spellman, Stoeckert, Aach, Ansorge, Ball, Causton, Gaasterland, Glenisson, Holstege, Kim, Markowitz, Matese, Parkinson, Robinson, Sarkans, Schulze-Kremer, Stewart, Taylor, Vilo, Vingron (bb0055) 2001; 29 Bessems, Coecke, Gouliarmou, Whelan, Worth (bb0035) 2015 National Research Council (US) (bb0430) 1983 National Research Council (bb0425) 2011 EPA (bb0155) 2016; 81 Tolonen, Pelkonen (bb0605) 2015; 332 Smith, Nolan, Edwards, Hatfield, Stewart, Ferguson, Lecluyse, Sahi (bb0560) 2012; 101 Judson, Martin, Reif, Houck, Knudsen, Rotroff, Xia, Sakamuru, Huang, Shinn, Austin, Kavlock, Dix (bb0295) 2010; 44 Villeneuve, Crump, Garcia-Reyero, Hecker, Hutchinson, LaLone, Landesmann, Lettieri, Munn, Nepelska, Ottinger, Vergauwen, Whelan (bb0630) 2014; 142 Woodhead, Brock, Roth, Shoaf, Brouwer, Church, Grammatopoulos, Stiles, Siler, Howell, Mosedale, Watkins, Shoda (bb0695) 2017; 155 EPA (bb0150) 2016 Judson, Richard, Dix, Houck, Elloumi, Martin, Cathey, Transue, Spencer, Wolf (bb0290) 2008; 233 Lukacova, Woltosz, Bolger (bb0390) 2009; 11 Lumen, Mattie, Fisher (bb0400) 2013; 133 National Research Council (US) (bb0435) 1994 Strobel, Burkhardt-Holm, Schmid, Segner (bb0565) 2015; 49 NTP (bb0450) 2016 Teeguarden, Tan, Edwards, Leonard, Anderson, Corley, Kile, Simonich, Stone, Tanguay, Waters, Harper, Williams (bb0590) 2016; 50 Gajewska, Worth, Urani, Briesen, Schramm (bb0220) 2014; 227 Varma, Steyn, Allerton, El-Kattan (bb0625) 2015; 32 Zaldivar Comenges, Joossens, Sala Benito, Worth, Paini (bb9000) 2017; 45 O'Flaherty (bb0465) 1981 Zhou, Fraczkiewicz, Lawless (bb0725) 2016 Phillips, Leonard, Grulke, Chang, Edwards, Brooks, Goldsmith, El-Masri, Tan (bb0510) 2016; 124 Kavlock, Chandler, Houck, Hunter, Judson, Kleinstreuer, Knudsen, Martin, Padilla, Reif, Richard, Rotroff, Sipes, Dix (bb0305) 2012; 25 Kleinstreuer, Judson, Reif, Sipes, Singh, Chandler, Dewoskin, Dix, Kavlock, Knudsen (bb0315) 2011; 119 Segner, Navas, Schäfers, Wenzel (bb0550) 2003; 54 Woodhead, Yang, Siler, Watkins, Brouwer, Barton, Howell (bb0690) 2014; 5 Ankley, LaLone, Gray, Villeneuve, Hornung (bb0015) 2016; 35 Hines (bb0255) 2007; 21 Jensen, Korte, Kahl, Pasha, Ankley (bb0285) 2001; 128 Jackson, Li, Chamberlain, Wang, Ferguson (bb0275) 2016; 44 Pellegatti (bb0490) 2014; 10 Poirier, Funk, Scherrmann, Lavé (bb0515) 2009; 6 Blaauboer (bb0040) 2010; 13 Haddad, Poulin, Krishnan (bb0240) 2000; 40 Lien, McKim, Hoffman, Jenson (bb0370) 2001; 51 Coecke, Pelkonen, Leite, Bernauer, Bessems, Bois, Gundert-Remy, Loizou, Testai, Zaldívar (bb0115) 2013; 27 Chang, Kleinstreuer, Ceger, Hsieh, Allen, Casey (bb0090) 2015; 1 Ghibellini, Vasist, Leslie, Heizer, Kowalsky, Calvo, Brouwer (bb0230) 2007; 81 Jamei, Marciniak, Feng, Barnett, Tucker, Rostami-Hodjegan (bb0280) 2009; 5 Leeson (bb0355) 1995; 29 Fischer (10.1016/j.tiv.2017.11.016_bb0200) 2017; 30 EPA (10.1016/j.tiv.2017.11.016_bb0145) 2015; 80 U.S. Food and Drug Administration (10.1016/j.tiv.2017.11.016_bb0620) Wilkinson (10.1016/j.tiv.2017.11.016_bb0685) 1975; 18 Hallifax (10.1016/j.tiv.2017.11.016_bb0245) 2012; 101 Zhu (10.1016/j.tiv.2017.11.016_bb0730) 2013; 30 Ankley (10.1016/j.tiv.2017.11.016_bb0015) 2016; 35 Dancik (10.1016/j.tiv.2017.11.016_bb0125) 2013; 1 Tice (10.1016/j.tiv.2017.11.016_bb0600) 2013; 121 EPA (10.1016/j.tiv.2017.11.016_bb0175) Hines (10.1016/j.tiv.2017.11.016_bb0260) 2010; 113 COSMOS (10.1016/j.tiv.2017.11.016_bb0120) Votano (10.1016/j.tiv.2017.11.016_bb0640) 2004; 8 Loizou (10.1016/j.tiv.2017.11.016_bb0385) 2011; 2 Fouchécourt (10.1016/j.tiv.2017.11.016_bb0205) 2001; 274 Yang (10.1016/j.tiv.2017.11.016_bb0710) 2015; 353 Judson (10.1016/j.tiv.2017.11.016_bb0295) 2010; 44 Bow (10.1016/j.tiv.2017.11.016_bb0050) 2008; 36 Tonnelier (10.1016/j.tiv.2017.11.016_bb0610) 2012; 86 McNally (10.1016/j.tiv.2017.11.016_bb0415) 2011; 2 Jensen (10.1016/j.tiv.2017.11.016_bb0285) 2001; 128 Rowland (10.1016/j.tiv.2017.11.016_bb0530) 2011; 51 Wetmore (10.1016/j.tiv.2017.11.016_bb0680) 2015; 148 Lipscomb (10.1016/j.tiv.2017.11.016_bb0375) 1998; 152 Slob (10.1016/j.tiv.2017.11.016_bb0555) 1997; 27 Yoon (10.1016/j.tiv.2017.11.016_bb0720) 2014; 28 Strobel (10.1016/j.tiv.2017.11.016_bb0565) 2015; 49 Péry (10.1016/j.tiv.2017.11.016_bb0500) 2014; 48 Ankley (10.1016/j.tiv.2017.11.016_bb0010) 2004; 45 Sullivan (10.1016/j.tiv.2017.11.016_bb0570) 2016; 44 Wang (10.1016/j.tiv.2017.11.016_bb0660) 2010; 38 Alves (10.1016/j.tiv.2017.11.016_bb0005) 2017 Sala Benito (10.1016/j.tiv.2017.11.016_bb0535) 2017 Villeneuve (10.1016/j.tiv.2017.11.016_bb0630) 2014; 142 Rotroff (10.1016/j.tiv.2017.11.016_bb0525) 2010; 117 Watanabe (10.1016/j.tiv.2017.11.016_bb0665) 2007; 146 Swiss Institute of Bioinformatics (10.1016/j.tiv.2017.11.016_bb0580) Bois (10.1016/j.tiv.2017.11.016_bb0045) 2017; 392 Clark (10.1016/j.tiv.2017.11.016_bb0110) 2004; 24 EPA (10.1016/j.tiv.2017.11.016_bb0165) Perkins (10.1016/j.tiv.2017.11.016_bb0495) 2013; 121 Zaldivar Comenges (10.1016/j.tiv.2017.11.016_bb9000) 2017; 45 Kearns (10.1016/j.tiv.2017.11.016_bb0310) 2003; 349 Kramer (10.1016/j.tiv.2017.11.016_bb0335) 2015; 30 Lien (10.1016/j.tiv.2017.11.016_bb0370) 2001; 51 Yang (10.1016/j.tiv.2017.11.016_bb0705) 2014; 96 Dancik (10.1016/j.tiv.2017.11.016_bb0130) 2015; 55 Li (10.1016/j.tiv.2017.11.016_bb0360) 2010; 7 Lien (10.1016/j.tiv.2017.11.016_bb0365) 1994; 13 Judson (10.1016/j.tiv.2017.11.016_bb0300) 2011; 24 Lukacova (10.1016/j.tiv.2017.11.016_bb0390) 2009; 11 Gajewska (10.1016/j.tiv.2017.11.016_bb0220) 2014; 227 EPA (10.1016/j.tiv.2017.11.016_bb0155) 2016; 81 Schmitt (10.1016/j.tiv.2017.11.016_bb0545) 2008; 22 NTP (10.1016/j.tiv.2017.11.016_bb0450) Nichols (10.1016/j.tiv.2017.11.016_bb0440) 1990; 106 Coecke (10.1016/j.tiv.2017.11.016_bb0115) 2013; 27 Wetmore (10.1016/j.tiv.2017.11.016_bb0670) 2012; 125 Zhou (10.1016/j.tiv.2017.11.016_bb0725) 2016 Wambaugh (10.1016/j.tiv.2017.11.016_bb0650) 2014; 48 EPA (10.1016/j.tiv.2017.11.016_bb0170) Judson (10.1016/j.tiv.2017.11.016_bb0290) 2008; 233 Lumen (10.1016/j.tiv.2017.11.016_bb0395) 2017; 314 Pellegatti (10.1016/j.tiv.2017.11.016_bb0490) 2014; 10 Harper (10.1016/j.tiv.2017.11.016_bb0250) 2008; 10 Jamei (10.1016/j.tiv.2017.11.016_bb0280) 2009; 5 Lee (10.1016/j.tiv.2017.11.016_bb0350) 2013; 13 European Union (10.1016/j.tiv.2017.11.016_bb0185) 2012; 167 Woodhead (10.1016/j.tiv.2017.11.016_bb0695) 2017; 155 Barton (10.1016/j.tiv.2017.11.016_bb0025) 2007; 99 NTP (10.1016/j.tiv.2017.11.016_bb0455) Swift (10.1016/j.tiv.2017.11.016_bb0575) 2010; 42 Lumen (10.1016/j.tiv.2017.11.016_bb0405) 2015; 6 Kleinstreuer (10.1016/j.tiv.2017.11.016_bb0320) 2016; 124 Chang (10.1016/j.tiv.2017.11.016_bb0090) 2015; 1 LaLone (10.1016/j.tiv.2017.11.016_bb0340) 2016; 153 Tan (10.1016/j.tiv.2017.11.016_bb0585) 2007; 17 Knudsen (10.1016/j.tiv.2017.11.016_bb0330) 2011; 93 Armitage (10.1016/j.tiv.2017.11.016_bb0020) 2014; 48 OECD (10.1016/j.tiv.2017.11.016_bb0460) 2016 Parrott (10.1016/j.tiv.2017.11.016_bb0475) 2016 Caldwell (10.1016/j.tiv.2017.11.016_bb0075) 2012; 2012 Thomas (10.1016/j.tiv.2017.11.016_bb0595) 2013; 136 Campbell (10.1016/j.tiv.2017.11.016_bb0080) 2012; 929 Groothuis (10.1016/j.tiv.2017.11.016_bb0235) 2015; 332 Bujard (10.1016/j.tiv.2017.11.016_bb0070) 2015; 77 Hiratsuka (10.1016/j.tiv.2017.11.016_bb0265) 2012; 27 National Research Council (US) (10.1016/j.tiv.2017.11.016_bb0430) 1983 Smith (10.1016/j.tiv.2017.11.016_bb0560) 2012; 101 Wagner (10.1016/j.tiv.2017.11.016_bb0645) 2015; 4 Lawless (10.1016/j.tiv.2017.11.016_bb0345) 2015 Parhizgari (10.1016/j.tiv.2017.11.016_bb0470) 2014; 33 Wetmore (10.1016/j.tiv.2017.11.016_bb0675) 2014; 142 Pearce (10.1016/j.tiv.2017.11.016_bb0485) 2017; 79 Casey (10.1016/j.tiv.2017.11.016_bb0085) 2015; 54 Salem (10.1016/j.tiv.2017.11.016_bb0540) 2014; 53 EPA (10.1016/j.tiv.2017.11.016_bb0160) Phillips (10.1016/j.tiv.2017.11.016_bb0510) 2016; 124 Woodhead (10.1016/j.tiv.2017.11.016_bb0690) 2014; 5 Chiba (10.1016/j.tiv.2017.11.016_bb0100) 2009; 11 Gajewska (10.1016/j.tiv.2017.11.016_bb0225) 2015; 75 Poirier (10.1016/j.tiv.2017.11.016_bb0515) 2009; 6 Frazier (10.1016/j.tiv.2017.11.016_bb0210) 1995; 9 National Research Council (US) (10.1016/j.tiv.2017.11.016_bb0435) 1994 Ring (10.1016/j.tiv.2017.11.016_bb0520) 2017; 106 Segner (10.1016/j.tiv.2017.11.016_bb0550) 2003; 54 NIEHS (10.1016/j.tiv.2017.11.016_bb0445) Bessems (10.1016/j.tiv.2017.11.016_bb0035) 2015 Patlewicz (10.1016/j.tiv.2017.11.016_bb0480) 2015; 71 Brouwer (10.1016/j.tiv.2017.11.016_bb0060) 2013; 94 Ghibellini (10.1016/j.tiv.2017.11.016_bb0230) 2007; 81 Teeguarden (10.1016/j.tiv.2017.11.016_bb0590) 2016; 50 Varma (10.1016/j.tiv.2017.11.016_bb0625) 2015; 32 Hines (10.1016/j.tiv.2017.11.016_bb0255) 2007; 21 Chu (10.1016/j.tiv.2017.11.016_bb0105) 2013; 94 El-Masri (10.1016/j.tiv.2017.11.016_bb0140) 2016; 152 Fujiwara (10.1016/j.tiv.2017.11.016_bb0215) 2003; 92 Liu (10.1016/j.tiv.2017.11.016_bb0380) 1999; 27 Yoon (10.1016/j.tiv.2017.11.016_bb0715) 2012 U.S. Fish and Wildlife Service (10.1016/j.tiv.2017.11.016_bb0615) Tolonen (10.1016/j.tiv.2017.11.016_bb0605) 2015; 332 Kleinstreuer (10.1016/j.tiv.2017.11.016_bb0325) 2016; 76 Yang (10.1016/j.tiv.2017.11.016_bb0700) 2013; 36 Kleinstreuer (10.1016/j.tiv.2017.11.016_bb0315) 2011; 119 McLanahan (10.1016/j.tiv.2017.11.016_bb0410) 2012; 126 Ferguson (10.1016/j.tiv.2017.11.016_bb0190) 2014 Dansirikul (10.1016/j.tiv.2017.11.016_bb0135) 2005; 35 Villeneuve (10.1016/j.tiv.2017.11.016_bb0635) 2014; 142 Filer (10.1016/j.tiv.2017.11.016_bb0195) 2017; 33 European Union (10.1016/j.tiv.2017.11.016_bb0180) 2009; 309 Brazma (10.1016/j.tiv.2017.11.016_bb0055) 2001; 29 Haddad (10.1016/j.tiv.2017.11.016_bb0240) 2000; 40 O'Flaherty (10.1016/j.tiv.2017.11.016_bb0465) 1981 Peyret (10.1016/j.tiv.2017.11.016_bb0505) 2010; 249 EPA (10.1016/j.tiv.2017.11.016_bb0150) Lumen (10.1016/j.tiv.2017.11.016_bb0400) 2013; 133 Wambaugh (10.1016/j.tiv.2017.11.016_bb0655) 2015; 147 Mundy (10.1016/j.tiv.2017.11.016_bb0420) 2004; 82 Bell (10.1016/j.tiv.2017.11.016_bb0030) 2016; 6 Kavlock (10.1016/j.tiv.2017.11.016_bb0305) 2012; 25 National Research Council (10.1016/j.tiv.2017.11.016_bb0425) 2011 Blaauboer (10.1016/j.tiv.2017.11.016_bb0040) 2010; 13 Horton (10.1016/j.tiv.2017.11.016_bb0270) 2015; 143 Jackson (10.1016/j.tiv.2017.11.016_bb0275) 2016; 44 Leeson (10.1016/j.tiv.2017.11.016_bb0355) 1995; 29
References_xml	– year: 2016 ident: bb0460 article-title: Test No. 455: Performance-based Test Guideline for Stably Transfected Transactivation in Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists – volume: 6 start-page: 1716 year: 2009 end-page: 1733 ident: bb0515 article-title: Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine publication-title: Mol. Pharm. – year: 2017 ident: bb0175 article-title: Summary of the Federal Insecticide, Fungicide, and Rodenticide Act – volume: 227 start-page: 189 year: 2014 end-page: 202 ident: bb0220 article-title: Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients publication-title: Toxicol. Lett. – volume: 2 year: 2011 ident: bb0385 article-title: MEGen: a physiologically based pharmacokinetic model generator publication-title: Front. Pharmacol. – volume: 7 start-page: 630 year: 2010 end-page: 641 ident: bb0360 article-title: Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters publication-title: Mol. Pharm. – volume: 119 start-page: 1596 year: 2011 end-page: 1603 ident: bb0315 article-title: Environmental impact on vascular development predicted by high-throughput screening publication-title: Environ. Health Perspect. – volume: 21 start-page: 169 year: 2007 end-page: 175 ident: bb0255 article-title: Ontogeny of human hepatic cytochromes P450 publication-title: J. Biochem. Mol. Toxicol. – year: 2017 ident: bb0165 article-title: Use of High Throughput Assays and Computational Tools in the Endocrine Disruptor Screening Program – volume: 33 start-page: 1064 year: 2014 end-page: 1071 ident: bb0470 article-title: A physiologically-based pharmacokinetic model for disposition of 2,3,7,8-TCDD in fathead minnow and medaka publication-title: Environ. Toxicol. Chem. – year: 2017 ident: bb0455 article-title: In Vitro to in Vivo Extrapolation for High Throughput Prioritization and Decision Making – volume: 29 start-page: 365 year: 2001 end-page: 371 ident: bb0055 article-title: Minimum information about a microarray experiment (MIAME)-toward standards for microarray data publication-title: Nat. Genet. – volume: 101 start-page: 2645 year: 2012 end-page: 2652 ident: bb0245 article-title: Evaluation of hepatic clearance prediction using in vitro data: emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs publication-title: J. Pharm. Sci. – volume: 10 start-page: 200 year: 2008 end-page: 207 ident: bb0250 article-title: Reaction phenotyping: current industry efforts to identify enzymes responsible for metabolizing drug candidates publication-title: AAPS J. – volume: 233 start-page: 7 year: 2008 end-page: 13 ident: bb0290 article-title: ACToR--aggregated computational toxicology resource publication-title: Toxicol. Appl. Pharmacol. – volume: 13 start-page: 1195 year: 1994 end-page: 1205 ident: bb0365 article-title: Modeling the accumulation of three waterborne chlorinated ethanes in fathead minnows (Pimephales promelas): a physiologically based approach publication-title: Environ. Toxicol. Chem. – year: 2017 ident: bb0005 article-title: Chemical toxicity prediction for major classes of industrial chemicals: is it possible to develop universal models covering cosmetics, drugs, and pesticides? publication-title: Food Chem. Toxicol. – volume: 32 start-page: 3785 year: 2015 end-page: 3802 ident: bb0625 article-title: Predicting clearance mechanism in drug discovery: extended clearance classification system (ECCS) publication-title: Pharm. Res. – volume: 42 start-page: 446 year: 2010 end-page: 471 ident: bb0575 article-title: Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity publication-title: Drug Metab. Rev. – volume: 13 start-page: 242 year: 2010 end-page: 252 ident: bb0040 article-title: Biokinetic modeling and in vitro–in vivo extrapolations publication-title: J. Toxicol. Environ. Health – volume: 33 start-page: 618 year: 2017 end-page: 620 ident: bb0195 article-title: tcpl: The ToxCast pipeline for high-throughput screening data publication-title: Bioinformatics – volume: 332 start-page: 30 year: 2015 end-page: 40 ident: bb0235 article-title: Dose metric considerations in in vitro assays to improve quantitative in vitro-in vivo dose extrapolations publication-title: Toxicology – volume: 48 start-page: 12760 year: 2014 end-page: 12767 ident: bb0650 article-title: High throughput heuristics for prioritizing human exposure to environmental chemicals publication-title: Environ. Sci. Technol. – year: 2017 ident: bb0445 article-title: Small Business Programs (SBIR/STTR) – volume: 124 start-page: 53 year: 2016 end-page: 60 ident: bb0510 article-title: A workflow to investigate exposure and pharmacokinetic influences on high-throughput in vitro chemical screening based on adverse outcome pathways publication-title: Environ. Health Perspect. – volume: 13 start-page: 3529 year: 2013 end-page: 3537 ident: bb0350 article-title: Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte-hepatic stellate cell interactions and flow effects publication-title: Lab Chip – volume: 147 start-page: 55 year: 2015 end-page: 67 ident: bb0655 article-title: Toxicokinetic triage for environmental chemicals publication-title: Toxicol. Sci. – year: 1983 ident: bb0430 article-title: Risk Assessment in the Federal Government: Managing the Process – volume: 133 start-page: 320 year: 2013 end-page: 341 ident: bb0400 article-title: Evaluation of perturbations in serum thyroid hormones during human pregnancy due to dietary iodide and perchlorate exposure using a biologically based dose-response model publication-title: Toxicol. Sci. – volume: 126 start-page: 5 year: 2012 end-page: 15 ident: bb0410 article-title: Physiologically based pharmacokinetic model use in risk assessment--why being published is not enough publication-title: Toxicol. Sci. – volume: 45 start-page: 209 year: 2017 end-page: 221 ident: bb9000 article-title: Theoretical and mathematical foundation of the virtual cell based assay - a review publication-title: Toxicol. in Vitro – volume: 44 start-page: 5979 year: 2010 end-page: 5985 ident: bb0295 article-title: Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity publication-title: Environ. Sci. Technol. – volume: 2 year: 2011 ident: bb0415 article-title: A workflow for global sensitivity analysis of PBPK models publication-title: Predict. Toxicol. – volume: 50 start-page: 4579 year: 2016 end-page: 4586 ident: bb0590 article-title: Completing the link between exposure science and toxicology for improved environmental health decision making: the aggregate exposure pathway framework publication-title: Environ. Sci. Technol. – volume: 274 start-page: 125 year: 2001 end-page: 135 ident: bb0205 article-title: Quantitative structure-pharmacokinetic relationship modelling publication-title: Sci. Total Environ. – volume: 11 start-page: 323 year: 2009 end-page: 334 ident: bb0390 article-title: Prediction of modified release pharmacokinetics and pharmacodynamics from in vitro, immediate release, and intravenous data publication-title: AAPS J. – volume: 79 start-page: 1 year: 2017 end-page: 26 ident: bb0485 article-title: httk: R package for high-throughput toxicokinetics publication-title: J. Stat. Softw. – volume: 18 start-page: 377 year: 1975 end-page: 390 ident: bb0685 article-title: Commentary: a physiological approach to hepatic drug clearance publication-title: Clin. Pharmacol. Ther. – volume: 77 start-page: 273 year: 2015 end-page: 278 ident: bb0070 article-title: Modification of a PAMPA model to predict passive gastrointestinal absorption and plasma protein binding publication-title: Eur. J. Pharm. Sci. – volume: 22 start-page: 457 year: 2008 end-page: 467 ident: bb0545 article-title: General approach for the calculation of tissue to plasma partition coefficients publication-title: Toxicol. in Vitro – volume: 124 start-page: 556 year: 2016 end-page: 562 ident: bb0320 article-title: A curated database of rodent uterotrophic bioactivity publication-title: Environ. Health Perspect. – volume: 36 start-page: 198 year: 2008 end-page: 202 ident: bb0050 article-title: Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes publication-title: Drug Metab. Dispos. – volume: 106 start-page: 105 year: 2017 end-page: 118 ident: bb0520 article-title: Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability publication-title: Environ. Int. – volume: 113 start-page: 4 year: 2010 end-page: 26 ident: bb0260 article-title: Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population publication-title: Toxicol. Sci. – year: 2016 ident: bb0150 article-title: EPI Suite™ Estimation Programs Interface – year: 2016 ident: bb0160 article-title: Final Test Guidelines for Pesticides and Toxic Substances – volume: 4 start-page: 226 year: 2015 end-page: 230 ident: bb0645 article-title: Application of physiologically based pharmacokinetic (PBPK) modeling to support dose selection: report of an FDA public workshop on PBPK publication-title: CPT Pharmacomet. Syst. Pharmacol. – volume: 51 start-page: 45 year: 2011 end-page: 73 ident: bb0530 article-title: Physiologically-based pharmacokinetics in drug development and regulatory science publication-title: Annu. Rev. Pharmacol. Toxicol. – volume: 38 start-page: 1094 year: 2010 end-page: 1104 ident: bb0660 article-title: Confidence assessment of the Simcyp time-based approach and a static mathematical model in predicting clinical drug-drug interactions for mechanism-based CYP3A inhibitors publication-title: Drug Metab. Dispos. – volume: 142 start-page: 312 year: 2014 end-page: 320 ident: bb0630 article-title: Adverse outcome pathway (AOP) development I: strategies and principles publication-title: Toxicol. Sci. – volume: 314 start-page: 24 year: 2017 end-page: 38 ident: bb0395 article-title: Estimation of iodine nutrition and thyroid function status in late-gestation pregnant women in the United States: development and application of a population-based pregnancy model publication-title: Toxicol. Appl. Pharmacol. – volume: 35 start-page: 389 year: 2005 end-page: 403 ident: bb0135 article-title: Estimation of pharmacokinetic parameters from non-compartmental variables using Microsoft Excel publication-title: Comput. Biol. Med. – volume: 49 start-page: 8022 year: 2015 end-page: 8032 ident: bb0565 article-title: Benzo(a)pyrene metabolism and EROD and GST biotransformation activity in the liver of red- and white-blooded Antarctic fish publication-title: Environ. Sci. Technol. – volume: 5 year: 2014 ident: bb0690 article-title: Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury publication-title: Front. Pharmacol. – volume: 54 start-page: 170 year: 2015 end-page: 173 ident: bb0085 article-title: A new path forward: the interagency coordinating committee on the validation of alternative methods (ICCVAM) and National Toxicology Program's interagency Center for the Evaluation of alternative toxicological methods (NICEATM) publication-title: J. Am. Assoc. Lab. Anim. Sci. – volume: 30 start-page: 1197 year: 2017 end-page: 1208 ident: bb0200 article-title: Modeling exposure in the Tox21 in vitro bioassays publication-title: Chem. Res. Toxicol. – volume: 86 start-page: 393 year: 2012 end-page: 403 ident: bb0610 article-title: Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model publication-title: Arch. Toxicol. – volume: 125 start-page: 157 year: 2012 end-page: 174 ident: bb0670 article-title: Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment publication-title: Toxicol. Sci. – volume: 93 start-page: 312 year: 2011 end-page: 323 ident: bb0330 article-title: Disruption of embryonic vascular development in predictive toxicology publication-title: Birth Defects Res. C Embryo Today – year: 2013 ident: bb0580 article-title: Click2Drug – volume: 99 start-page: 395 year: 2007 end-page: 402 ident: bb0025 article-title: Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation publication-title: Toxicol. Sci. – volume: 11 year: 2009 ident: bb0100 article-title: Prediction of hepatic clearance in human from in vitro data for successful drug development publication-title: AAPS J. – volume: 75 start-page: 39 year: 2015 end-page: 49 ident: bb0225 article-title: In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine publication-title: Food Chem. Toxicol. – volume: 27 start-page: 1570 year: 2013 end-page: 1577 ident: bb0115 article-title: Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches publication-title: Toxicol. in Vitro – start-page: 441 year: 2014 end-page: 484 ident: bb0190 article-title: In vitro approaches to study drug–drug interactions publication-title: Drug Metabolism Prediction – volume: 1 start-page: 10 year: 2013 ident: bb0125 article-title: A framework incorporating the impact of exposure scenarios and application conditions on risk assessment of chemicals applied to skin publication-title: In Silico Pharmacol. – volume: 143 start-page: 1 year: 2015 end-page: 9 ident: bb0270 article-title: Co-occuring exposure to perchlorate, nitrate and thiocyanate alters thyroid function in healthy pregnant women publication-title: Environ. Res. – volume: 8 start-page: 379 year: 2004 end-page: 391 ident: bb0640 article-title: New predictors for several ADME/tox properties: aqueous solubility, human oral absorption, and Ames genotoxicity using topological descriptors publication-title: Mol. Divers. – volume: 29 start-page: 903 year: 1995 end-page: 915 ident: bb0355 article-title: In vitro/in vivo correlations publication-title: Drug Inf. J. – volume: 96 start-page: 589 year: 2014 end-page: 598 ident: bb0705 article-title: Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity publication-title: Clin. Pharmacol. Ther. – volume: 45 start-page: 469 year: 2004 end-page: 483 ident: bb0010 article-title: Small fish models for identifying and assessing the effects of endocrine-disrupting chemicals publication-title: ILAR J. – year: 2015 ident: bb0345 article-title: Prediction of oral bioavailability in silico publication-title: ISSX Annual Meeting – volume: 10 start-page: 1615 year: 2014 end-page: 1620 ident: bb0490 article-title: The debate on animal ADME studies in drug development: an update publication-title: Expert Opin. Drug Metab. Toxicol. – year: 2016 ident: bb0725 article-title: Using physiologically based pharmacokinetic modeling for in vitro in vivo extrapolation to predict chemical exposure [Poster] publication-title: In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making; Durham, NC – volume: 55 start-page: 50 year: 2015 end-page: 63 ident: bb0130 article-title: Estimation of in vivo dose of dermally applied chemicals leading to estrogen/androgen receptor-mediated toxicity from in vitro data--illustration with four reproductive toxicants publication-title: Reprod. Toxicol. – volume: 94 start-page: 95 year: 2013 end-page: 112 ident: bb0060 article-title: In vitro methods to support transporter evaluation in drug discovery and development publication-title: Clin. Pharmacol. Ther. – volume: 309 start-page: 1 year: 2009 end-page: 50 ident: bb0180 article-title: Regulation (EC) No. 1107/2009 of the European parliament and of the council concerning the placing of plant protection products on the market and repealing Council Directives 79/117/EEC and 91/414/EEC publication-title: Off. J. Eur. Union – volume: 6 year: 2015 ident: bb0405 article-title: Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system publication-title: Front. Pharmacol. – year: 2017 ident: bb0120 article-title: COSMOS KNIME Webportal – volume: 24 start-page: 1697 year: 2004 end-page: 1717 ident: bb0110 article-title: Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment publication-title: Risk Anal. – volume: 2012 start-page: 1 year: 2012 end-page: 10 ident: bb0075 article-title: Cutting edge PBPK models and analyses: providing the basis for future modeling efforts and bridges to emerging toxicology paradigms publication-title: J. Toxicol. – volume: 76 start-page: 39 year: 2016 end-page: 50 ident: bb0325 article-title: Adverse outcome pathways: from research to regulation scientific workshop report publication-title: Regul. Toxicol. Pharmacol. – volume: 332 start-page: 20 year: 2015 end-page: 29 ident: bb0605 article-title: Analytical challenges for conducting rapid metabolism characterization for QIVIVE publication-title: Toxicology – volume: 27 start-page: 261 year: 1997 end-page: 272 ident: bb0555 article-title: Structural identifiability of PBPK models: practical consequences for modeling strategies and study designs publication-title: Crit. Rev. Toxicol. – year: 1981 ident: bb0465 article-title: Toxicants and Drugs: Kinetics and Dynamics – volume: 54 start-page: 315 year: 2003 end-page: 322 ident: bb0550 article-title: Potencies of estrogenic compounds in in vitro screening assays and in life cycle tests with zebrafish in vivo publication-title: Ecotoxicol. Environ. Saf. – volume: 353 start-page: 415 year: 2015 end-page: 423 ident: bb0710 article-title: Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury publication-title: J. Pharmacol. Exp. Ther. – volume: 24 start-page: 451 year: 2011 end-page: 462 ident: bb0300 article-title: Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment publication-title: Chem. Res. Toxicol. – volume: 929 start-page: 439 year: 2012 end-page: 499 ident: bb0080 article-title: Physiologically based pharmacokinetic/toxicokinetic modeling publication-title: Methods Mol. Biol. – volume: 27 start-page: 68 year: 2012 end-page: 84 ident: bb0265 article-title: In vitro assessment of the allelic variants of cytochrome P450 publication-title: Drug Metab. Pharmacokinet. – volume: 349 start-page: 1157 year: 2003 end-page: 1167 ident: bb0310 article-title: Developmental pharmacology--drug disposition, action, and therapy in infants and children publication-title: N. Engl. J. Med. – volume: 142 start-page: 210 year: 2014 end-page: 224 ident: bb0675 article-title: Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing publication-title: Toxicol. Sci. – volume: 44 start-page: 1463 year: 2016 end-page: 1479 ident: bb0275 article-title: Contextualizing hepatocyte functionality of cryopreserved HepaRG cell cultures publication-title: Drug Metab. Dispos. – volume: 121 start-page: 1002 year: 2013 end-page: 1010 ident: bb0495 article-title: Current perspectives on the use of alternative species in human health and ecological hazard assessments publication-title: Environ. Health Perspect. – year: 2017 ident: bb0535 article-title: Automated workflows for modelling chemical fate, kinetics and toxicity [published online ahead of print 18 March 2017] publication-title: Toxicol. in Vitro – volume: 152 start-page: 230 year: 2016 end-page: 243 ident: bb0140 article-title: Integration of life-stage physiologically based pharmacokinetic models with adverse outcome pathways and environmental exposure models to screen for environmental hazards publication-title: Toxicol. Sci. – volume: 9 start-page: 845 year: 1995 end-page: 849 ident: bb0210 article-title: Interdisciplinary approach to toxicity test development and validation publication-title: Toxicol. in Vitro – volume: 101 start-page: 3989 year: 2012 end-page: 4002 ident: bb0560 article-title: A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes publication-title: J. Pharm. Sci. – volume: 142 start-page: 321 year: 2014 end-page: 330 ident: bb0635 article-title: Adverse outcome pathway development II: best practices publication-title: Toxicol. Sci. – volume: 392 start-page: 130 year: 2017 end-page: 139 ident: bb0045 article-title: Multiscale modelling approaches for assessing cosmetic ingredients safety publication-title: Toxicology – volume: 30 start-page: 1790 year: 2013 end-page: 1798 ident: bb0730 article-title: The use of pseudo-equilibrium constant affords improved QSAR models of human plasma protein binding publication-title: Pharm. Res. – volume: 117 start-page: 348 year: 2010 end-page: 358 ident: bb0525 article-title: Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening publication-title: Toxicol. Sci. – volume: 6 year: 2016 ident: bb0030 article-title: Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease publication-title: Sci. Rep. – volume: 5 start-page: 211 year: 2009 end-page: 223 ident: bb0280 article-title: The Simcyp® population-based ADME simulator publication-title: Expert Opin. Drug Metab. Toxicol. – volume: 30 start-page: 217 year: 2015 end-page: 224 ident: bb0335 article-title: Biokinetics in repeated-dosing in vitro drug toxicity studies publication-title: Toxicol. in Vitro – year: 2015 ident: bb0035 article-title: EURL ECVAM Strategy for Achieving 3Rs Impact in the Assessment of Toxicokinetics and Systemic Toxicity – volume: 136 start-page: 4 year: 2013 end-page: 18 ident: bb0595 article-title: Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework publication-title: Toxicol. Sci. – year: 2011 ident: bb0425 article-title: Reference Manual on Scientific Evidence – volume: 249 start-page: 197 year: 2010 end-page: 207 ident: bb0505 article-title: A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals publication-title: Toxicol. Appl. Pharmacol. – volume: 81 start-page: 67350 year: 2016 end-page: 67351 ident: bb0155 article-title: Request for public comments to be sent to EPA on peer review materials to inform the safe drinking water act decision making on perchlorate publication-title: Fed. Regist. – volume: 25 start-page: 1287 year: 2012 end-page: 1302 ident: bb0305 article-title: Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management publication-title: Chem. Res. Toxicol. – volume: 35 start-page: 2806 year: 2016 end-page: 2816 ident: bb0015 article-title: Evaluation of the scientific underpinnings for identifying estrogenic chemicals in nonmammalian taxa using mammalian test systems publication-title: Environ. Toxicol. Chem. – volume: 92 start-page: 1939 year: 2003 end-page: 1946 ident: bb0215 article-title: QSAR analysis of interstudy variable skin permeability based on the “latent membrane permeability” concept publication-title: J. Pharm. Sci. – year: 2015 ident: bb0615 article-title: Endangered Species – year: 2017 ident: bb0170 article-title: Rapid Chemical Exposure and Dose Research – volume: 106 start-page: 433 year: 1990 end-page: 447 ident: bb0440 article-title: A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish publication-title: Toxicol. Appl. Pharmacol. – volume: 94 start-page: 126 year: 2013 end-page: 141 ident: bb0105 article-title: Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver publication-title: Clin. Pharmacol. Ther. – volume: 1 start-page: 33 year: 2015 end-page: 44 ident: bb0090 article-title: Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity publication-title: Appl. Vitro Toxicol. – volume: 128 start-page: 127 year: 2001 end-page: 141 ident: bb0285 article-title: Aspects of basic reproductive biology and endocrinology in the fathead minnow (Pimephales promelas) publication-title: Comp. Biochem. Physiol. C: Toxicol. Pharmacol. – volume: 121 start-page: 756 year: 2013 end-page: 765 ident: bb0600 article-title: Improving the human hazard characterization of chemicals: a Tox21 update publication-title: Environ. Health Perspect. – volume: 51 start-page: 335 year: 2001 end-page: 350 ident: bb0370 article-title: A physiologically based toxicokinetic model for lake trout (Salvelinus namaycush) publication-title: Aquat. Toxicol. – volume: 153 start-page: 228 year: 2016 end-page: 245 ident: bb0340 article-title: Editor's highlight: sequence alignment to predict across species susceptibility (SeqAPASS): a web-based tool for addressing the challenges of cross-species extrapolation of chemical toxicity publication-title: Toxicol. Sci. – start-page: 323 year: 2012 end-page: 338 ident: bb0715 article-title: Use of in vitro data in PBPK models: an example of in vitro to in vivo extrapolation with carbaryl publication-title: Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment – volume: 28 start-page: 164 year: 2014 end-page: 170 ident: bb0720 article-title: Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds publication-title: Toxicol. in Vitro – volume: 71 start-page: 463 year: 2015 end-page: 477 ident: bb0480 article-title: Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes publication-title: Regul. Toxicol. Pharmacol. – volume: 152 start-page: 376 year: 1998 end-page: 387 ident: bb0375 article-title: In vitro to in vivo extrapolation for trichloroethylene metabolism in humans publication-title: Toxicol. Appl. Pharmacol. – year: 2016 ident: bb0450 article-title: West Virginia Chemical Spill – volume: 44 start-page: 411 year: 2016 end-page: 415 ident: bb0570 article-title: It takes a village: stakeholder participation is essential to transforming science publication-title: Altern. Lab. Anim – year: 1994 ident: bb0435 article-title: Science and Judgment in Risk Assessment – volume: 48 start-page: 9770 year: 2014 end-page: 9779 ident: bb0020 article-title: Application of mass balance models and the chemical activity concept to facilitate the use of in vitro toxicity data for risk assessment. Enviro publication-title: Sci. Technol. – volume: 81 start-page: 406 year: 2007 end-page: 413 ident: bb0230 article-title: In vitro-in vivo correlation of hepatobiliary drug clearance in humans publication-title: Clin. Pharmacol. Ther. – volume: 155 start-page: 61 year: 2017 end-page: 74 ident: bb0695 article-title: Application of a mechanistic model to evaluate putative mechanisms of tolvaptan drug-induced liver injury and identify patient susceptibility factors publication-title: Toxicol. Sci. – volume: 17 start-page: 591 year: 2007 end-page: 603 ident: bb0585 article-title: Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling publication-title: J. Expo. Sci. Environ. Epidemiol. – volume: 27 start-page: 637 year: 1999 end-page: 644 ident: bb0380 article-title: Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats publication-title: Drug Metab. Dispos. – start-page: 338 year: 2016 end-page: 350 ident: bb0475 article-title: Computer models for predicting drug absorption publication-title: Oral Drug Absorption: Prediction and Assessment – volume: 48 start-page: 781 year: 2014 end-page: 790 ident: bb0500 article-title: A physiologically based toxicokinetic model for the zebrafish Danio rerio publication-title: Environ. Sci. Technol. – year: 2017 ident: bb0620 article-title: Biomarker Qualification Program – volume: 53 start-page: 625 year: 2014 end-page: 636 ident: bb0540 article-title: A re-evaluation and validation of ontogeny functions for cytochrome P450 1A2 and 3A4 based on in vivo data publication-title: Clin. Pharmacokinet. – volume: 148 start-page: 121 year: 2015 end-page: 136 ident: bb0680 article-title: Incorporating high-throughput exposure predictions with dosimetry-adjusted in vitro bioactivity to inform chemical toxicity testing publication-title: Toxicol. Sci. – volume: 167 start-page: 1 year: 2012 end-page: 123 ident: bb0185 article-title: Regulation (EU) No 528/2012 of the European parliament and of the council of 22 May 2012 concerning the making available on the market and use of biocidal products (Text with EEA relevance) publication-title: Off. J. Eur. Union – volume: 146 start-page: 348 year: 2007 end-page: 356 ident: bb0665 article-title: What is normal? A characterization of the values and variability in reproductive endpoints of the fathead minnow, Pimephales promelas publication-title: Comp. Biochem. Physiol. C: Toxicol. Pharmacol. – volume: 82 start-page: 164 year: 2004 end-page: 169 ident: bb0420 article-title: Accumulation of PBDE-47 in primary cultures of rat neocortical cells publication-title: Toxicol. Sci. – volume: 80 start-page: 35350 year: 2015 end-page: 35355 ident: bb0145 article-title: Use of high throughput assays and computational tools; endocrine disruptor screening program; notice of availability and opportunity for comment publication-title: Fed. Regist. – volume: 36 start-page: 192 year: 2013 end-page: 200 ident: bb0700 article-title: A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolation publication-title: J. Vet. Pharmacol. Ther. – volume: 40 start-page: 839 year: 2000 end-page: 843 ident: bb0240 article-title: Relative lipid content as the sole mechanistic determinant of the adipose tissue: blood partition coefficients of highly lipophilic organic chemicals publication-title: Chemosphere – volume: 106 start-page: 105 year: 2017 ident: 10.1016/j.tiv.2017.11.016_bb0520 article-title: Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability publication-title: Environ. Int. doi: 10.1016/j.envint.2017.06.004 – volume: 44 start-page: 1463 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0275 article-title: Contextualizing hepatocyte functionality of cryopreserved HepaRG cell cultures publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.116.069831 – volume: 99 start-page: 395 year: 2007 ident: 10.1016/j.tiv.2017.11.016_bb0025 article-title: Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfm100 – ident: 10.1016/j.tiv.2017.11.016_bb0620 – volume: 142 start-page: 321 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0635 article-title: Adverse outcome pathway development II: best practices publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfu200 – volume: 5 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0690 article-title: Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury publication-title: Front. Pharmacol. doi: 10.3389/fphar.2014.00240 – volume: 353 start-page: 415 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0710 article-title: Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.114.221564 – volume: 167 start-page: 1 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0185 article-title: Regulation (EU) No 528/2012 of the European parliament and of the council of 22 May 2012 concerning the making available on the market and use of biocidal products (Text with EEA relevance) publication-title: Off. J. Eur. Union – ident: 10.1016/j.tiv.2017.11.016_bb0160 – volume: 5 start-page: 211 year: 2009 ident: 10.1016/j.tiv.2017.11.016_bb0280 article-title: The Simcyp® population-based ADME simulator publication-title: Expert Opin. Drug Metab. Toxicol. doi: 10.1517/17425250802691074 – volume: 9 start-page: 845 year: 1995 ident: 10.1016/j.tiv.2017.11.016_bb0210 article-title: Interdisciplinary approach to toxicity test development and validation publication-title: Toxicol. in Vitro doi: 10.1016/0887-2333(95)00084-4 – volume: 929 start-page: 439 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0080 article-title: Physiologically based pharmacokinetic/toxicokinetic modeling publication-title: Methods Mol. Biol. doi: 10.1007/978-1-62703-050-2_18 – volume: 54 start-page: 170 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0085 article-title: A new path forward: the interagency coordinating committee on the validation of alternative methods (ICCVAM) and National Toxicology Program's interagency Center for the Evaluation of alternative toxicological methods (NICEATM) publication-title: J. Am. Assoc. Lab. Anim. Sci. – volume: 143 start-page: 1 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0270 article-title: Co-occuring exposure to perchlorate, nitrate and thiocyanate alters thyroid function in healthy pregnant women publication-title: Environ. Res. doi: 10.1016/j.envres.2015.09.013 – volume: 44 start-page: 411 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0570 article-title: It takes a village: stakeholder participation is essential to transforming science publication-title: Altern. Lab. Anim doi: 10.1177/026119291604400517 – volume: 153 start-page: 228 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0340 article-title: Editor's highlight: sequence alignment to predict across species susceptibility (SeqAPASS): a web-based tool for addressing the challenges of cross-species extrapolation of chemical toxicity publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfw119 – volume: 94 start-page: 126 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0105 article-title: Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver publication-title: Clin. Pharmacol. Ther. doi: 10.1038/clpt.2013.78 – volume: 124 start-page: 53 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0510 article-title: A workflow to investigate exposure and pharmacokinetic influences on high-throughput in vitro chemical screening based on adverse outcome pathways publication-title: Environ. Health Perspect. doi: 10.1289/ehp.1409450 – volume: 48 start-page: 12760 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0650 article-title: High throughput heuristics for prioritizing human exposure to environmental chemicals publication-title: Environ. Sci. Technol. doi: 10.1021/es503583j – volume: 113 start-page: 4 year: 2010 ident: 10.1016/j.tiv.2017.11.016_bb0260 article-title: Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfp217 – year: 1983 ident: 10.1016/j.tiv.2017.11.016_bb0430 – volume: 94 start-page: 95 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0060 article-title: In vitro methods to support transporter evaluation in drug discovery and development publication-title: Clin. Pharmacol. Ther. doi: 10.1038/clpt.2013.81 – volume: 7 start-page: 630 year: 2010 ident: 10.1016/j.tiv.2017.11.016_bb0360 article-title: Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters publication-title: Mol. Pharm. doi: 10.1021/mp9001574 – volume: 152 start-page: 376 year: 1998 ident: 10.1016/j.tiv.2017.11.016_bb0375 article-title: In vitro to in vivo extrapolation for trichloroethylene metabolism in humans publication-title: Toxicol. Appl. Pharmacol. doi: 10.1006/taap.1998.8485 – volume: 18 start-page: 377 year: 1975 ident: 10.1016/j.tiv.2017.11.016_bb0685 article-title: Commentary: a physiological approach to hepatic drug clearance publication-title: Clin. Pharmacol. Ther. doi: 10.1002/cpt1975184377 – volume: 92 start-page: 1939 year: 2003 ident: 10.1016/j.tiv.2017.11.016_bb0215 article-title: QSAR analysis of interstudy variable skin permeability based on the “latent membrane permeability” concept publication-title: J. Pharm. Sci. doi: 10.1002/jps.10462 – volume: 44 start-page: 5979 year: 2010 ident: 10.1016/j.tiv.2017.11.016_bb0295 article-title: Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity publication-title: Environ. Sci. Technol. doi: 10.1021/es102150z – volume: 25 start-page: 1287 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0305 article-title: Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management publication-title: Chem. Res. Toxicol. doi: 10.1021/tx3000939 – volume: 79 start-page: 1 issue: 1 year: 2017 ident: 10.1016/j.tiv.2017.11.016_bb0485 article-title: httk: R package for high-throughput toxicokinetics publication-title: J. Stat. Softw. – volume: 93 start-page: 312 year: 2011 ident: 10.1016/j.tiv.2017.11.016_bb0330 article-title: Disruption of embryonic vascular development in predictive toxicology publication-title: Birth Defects Res. C Embryo Today doi: 10.1002/bdrc.20223 – volume: 27 start-page: 68 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0265 article-title: In vitro assessment of the allelic variants of cytochrome P450 publication-title: Drug Metab. Pharmacokinet. doi: 10.2133/dmpk.DMPK-11-RV-090 – volume: 2012 start-page: 1 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0075 article-title: Cutting edge PBPK models and analyses: providing the basis for future modeling efforts and bridges to emerging toxicology paradigms publication-title: J. Toxicol. – volume: 6 start-page: 1716 year: 2009 ident: 10.1016/j.tiv.2017.11.016_bb0515 article-title: Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine publication-title: Mol. Pharm. doi: 10.1021/mp8002495 – volume: 27 start-page: 637 year: 1999 ident: 10.1016/j.tiv.2017.11.016_bb0380 article-title: Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats publication-title: Drug Metab. Dispos. doi: 10.1016/S0090-9556(24)15299-3 – volume: 13 start-page: 3529 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0350 article-title: Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte-hepatic stellate cell interactions and flow effects publication-title: Lab Chip doi: 10.1039/c3lc50197c – ident: 10.1016/j.tiv.2017.11.016_bb0175 – start-page: 323 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0715 article-title: Use of in vitro data in PBPK models: an example of in vitro to in vivo extrapolation with carbaryl – ident: 10.1016/j.tiv.2017.11.016_bb0450 – volume: 142 start-page: 210 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0675 article-title: Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfu169 – volume: 27 start-page: 261 year: 1997 ident: 10.1016/j.tiv.2017.11.016_bb0555 article-title: Structural identifiability of PBPK models: practical consequences for modeling strategies and study designs publication-title: Crit. Rev. Toxicol. doi: 10.3109/10408449709089895 – ident: 10.1016/j.tiv.2017.11.016_bb0615 – volume: 24 start-page: 1697 year: 2004 ident: 10.1016/j.tiv.2017.11.016_bb0110 article-title: Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment publication-title: Risk Anal. doi: 10.1111/j.0272-4332.2004.00561.x – volume: 24 start-page: 451 year: 2011 ident: 10.1016/j.tiv.2017.11.016_bb0300 article-title: Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment publication-title: Chem. Res. Toxicol. doi: 10.1021/tx100428e – volume: 42 start-page: 446 year: 2010 ident: 10.1016/j.tiv.2017.11.016_bb0575 article-title: Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity publication-title: Drug Metab. Rev. doi: 10.3109/03602530903491881 – volume: 1 start-page: 33 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0090 article-title: Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity publication-title: Appl. Vitro Toxicol. doi: 10.1089/aivt.2014.0005 – volume: 22 start-page: 457 year: 2008 ident: 10.1016/j.tiv.2017.11.016_bb0545 article-title: General approach for the calculation of tissue to plasma partition coefficients publication-title: Toxicol. in Vitro doi: 10.1016/j.tiv.2007.09.010 – volume: 121 start-page: 756 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0600 article-title: Improving the human hazard characterization of chemicals: a Tox21 update publication-title: Environ. Health Perspect. doi: 10.1289/ehp.1205784 – volume: 227 start-page: 189 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0220 article-title: Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2014.03.013 – year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0460 – volume: 124 start-page: 556 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0320 article-title: A curated database of rodent uterotrophic bioactivity publication-title: Environ. Health Perspect. doi: 10.1289/ehp.1510183 – volume: 76 start-page: 39 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0325 article-title: Adverse outcome pathways: from research to regulation scientific workshop report publication-title: Regul. Toxicol. Pharmacol. doi: 10.1016/j.yrtph.2016.01.007 – volume: 36 start-page: 198 year: 2008 ident: 10.1016/j.tiv.2017.11.016_bb0050 article-title: Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.107.018200 – ident: 10.1016/j.tiv.2017.11.016_bb0580 – volume: 155 start-page: 61 year: 2017 ident: 10.1016/j.tiv.2017.11.016_bb0695 article-title: Application of a mechanistic model to evaluate putative mechanisms of tolvaptan drug-induced liver injury and identify patient susceptibility factors publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfw193 – volume: 28 start-page: 164 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0720 article-title: Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds publication-title: Toxicol. in Vitro doi: 10.1016/j.tiv.2013.10.023 – volume: 40 start-page: 839 year: 2000 ident: 10.1016/j.tiv.2017.11.016_bb0240 article-title: Relative lipid content as the sole mechanistic determinant of the adipose tissue: blood partition coefficients of highly lipophilic organic chemicals publication-title: Chemosphere doi: 10.1016/S0045-6535(99)00279-9 – year: 1994 ident: 10.1016/j.tiv.2017.11.016_bb0435 – volume: 49 start-page: 8022 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0565 article-title: Benzo(a)pyrene metabolism and EROD and GST biotransformation activity in the liver of red- and white-blooded Antarctic fish publication-title: Environ. Sci. Technol. doi: 10.1021/acs.est.5b00176 – volume: 38 start-page: 1094 year: 2010 ident: 10.1016/j.tiv.2017.11.016_bb0660 article-title: Confidence assessment of the Simcyp time-based approach and a static mathematical model in predicting clinical drug-drug interactions for mechanism-based CYP3A inhibitors publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.110.032177 – volume: 30 start-page: 1790 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0730 article-title: The use of pseudo-equilibrium constant affords improved QSAR models of human plasma protein binding publication-title: Pharm. Res. doi: 10.1007/s11095-013-1023-6 – volume: 21 start-page: 169 year: 2007 ident: 10.1016/j.tiv.2017.11.016_bb0255 article-title: Ontogeny of human hepatic cytochromes P450 publication-title: J. Biochem. Mol. Toxicol. doi: 10.1002/jbt.20179 – volume: 119 start-page: 1596 year: 2011 ident: 10.1016/j.tiv.2017.11.016_bb0315 article-title: Environmental impact on vascular development predicted by high-throughput screening publication-title: Environ. Health Perspect. doi: 10.1289/ehp.1103412 – volume: 314 start-page: 24 year: 2017 ident: 10.1016/j.tiv.2017.11.016_bb0395 article-title: Estimation of iodine nutrition and thyroid function status in late-gestation pregnant women in the United States: development and application of a population-based pregnancy model publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2016.10.026 – volume: 332 start-page: 30 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0235 article-title: Dose metric considerations in in vitro assays to improve quantitative in vitro-in vivo dose extrapolations publication-title: Toxicology doi: 10.1016/j.tox.2013.08.012 – volume: 125 start-page: 157 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0670 article-title: Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfr254 – volume: 51 start-page: 335 year: 2001 ident: 10.1016/j.tiv.2017.11.016_bb0370 article-title: A physiologically based toxicokinetic model for lake trout (Salvelinus namaycush) publication-title: Aquat. Toxicol. doi: 10.1016/S0166-445X(00)00117-X – volume: 36 start-page: 192 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0700 article-title: A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolation publication-title: J. Vet. Pharmacol. Ther. doi: 10.1111/j.1365-2885.2012.01419.x – volume: 392 start-page: 130 issn: 0300-483X year: 2017 ident: 10.1016/j.tiv.2017.11.016_bb0045 article-title: Multiscale modelling approaches for assessing cosmetic ingredients safety publication-title: Toxicology doi: 10.1016/j.tox.2016.05.026 – volume: 29 start-page: 365 year: 2001 ident: 10.1016/j.tiv.2017.11.016_bb0055 article-title: Minimum information about a microarray experiment (MIAME)-toward standards for microarray data publication-title: Nat. Genet. doi: 10.1038/ng1201-365 – ident: 10.1016/j.tiv.2017.11.016_bb0165 – volume: 10 start-page: 200 year: 2008 ident: 10.1016/j.tiv.2017.11.016_bb0250 article-title: Reaction phenotyping: current industry efforts to identify enzymes responsible for metabolizing drug candidates publication-title: AAPS J. doi: 10.1208/s12248-008-9019-6 – volume: 75 start-page: 39 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0225 article-title: In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2014.10.017 – volume: 17 start-page: 591 year: 2007 ident: 10.1016/j.tiv.2017.11.016_bb0585 article-title: Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling publication-title: J. Expo. Sci. Environ. Epidemiol. doi: 10.1038/sj.jes.7500540 – volume: 48 start-page: 781 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0500 article-title: A physiologically based toxicokinetic model for the zebrafish Danio rerio publication-title: Environ. Sci. Technol. doi: 10.1021/es404301q – volume: 332 start-page: 20 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0605 article-title: Analytical challenges for conducting rapid metabolism characterization for QIVIVE publication-title: Toxicology doi: 10.1016/j.tox.2013.08.010 – volume: 35 start-page: 2806 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0015 article-title: Evaluation of the scientific underpinnings for identifying estrogenic chemicals in nonmammalian taxa using mammalian test systems publication-title: Environ. Toxicol. Chem. doi: 10.1002/etc.3456 – year: 1981 ident: 10.1016/j.tiv.2017.11.016_bb0465 – ident: 10.1016/j.tiv.2017.11.016_bb0150 – volume: 8 start-page: 379 year: 2004 ident: 10.1016/j.tiv.2017.11.016_bb0640 article-title: New predictors for several ADME/tox properties: aqueous solubility, human oral absorption, and Ames genotoxicity using topological descriptors publication-title: Mol. Divers. doi: 10.1023/B:MODI.0000047512.82293.75 – volume: 11 start-page: 323 year: 2009 ident: 10.1016/j.tiv.2017.11.016_bb0390 article-title: Prediction of modified release pharmacokinetics and pharmacodynamics from in vitro, immediate release, and intravenous data publication-title: AAPS J. doi: 10.1208/s12248-009-9107-2 – volume: 86 start-page: 393 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0610 article-title: Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model publication-title: Arch. Toxicol. doi: 10.1007/s00204-011-0768-0 – volume: 10 start-page: 1615 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0490 article-title: The debate on animal ADME studies in drug development: an update publication-title: Expert Opin. Drug Metab. Toxicol. doi: 10.1517/17425255.2015.979152 – ident: 10.1016/j.tiv.2017.11.016_bb0455 – volume: 233 start-page: 7 year: 2008 ident: 10.1016/j.tiv.2017.11.016_bb0290 article-title: ACToR--aggregated computational toxicology resource publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2007.12.037 – volume: 71 start-page: 463 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0480 article-title: Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes publication-title: Regul. Toxicol. Pharmacol. doi: 10.1016/j.yrtph.2015.02.011 – ident: 10.1016/j.tiv.2017.11.016_bb0170 – volume: 121 start-page: 1002 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0495 article-title: Current perspectives on the use of alternative species in human health and ecological hazard assessments publication-title: Environ. Health Perspect. doi: 10.1289/ehp.1306638 – volume: 142 start-page: 312 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0630 article-title: Adverse outcome pathway (AOP) development I: strategies and principles publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfu199 – volume: 128 start-page: 127 year: 2001 ident: 10.1016/j.tiv.2017.11.016_bb0285 article-title: Aspects of basic reproductive biology and endocrinology in the fathead minnow (Pimephales promelas) publication-title: Comp. Biochem. Physiol. C: Toxicol. Pharmacol. – volume: 126 start-page: 5 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0410 article-title: Physiologically based pharmacokinetic model use in risk assessment--why being published is not enough publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfr295 – volume: 54 start-page: 315 year: 2003 ident: 10.1016/j.tiv.2017.11.016_bb0550 article-title: Potencies of estrogenic compounds in in vitro screening assays and in life cycle tests with zebrafish in vivo publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/S0147-6513(02)00040-4 – volume: 136 start-page: 4 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0595 article-title: Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kft178 – volume: 274 start-page: 125 year: 2001 ident: 10.1016/j.tiv.2017.11.016_bb0205 article-title: Quantitative structure-pharmacokinetic relationship modelling publication-title: Sci. Total Environ. doi: 10.1016/S0048-9697(01)00743-4 – year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0345 article-title: Prediction of oral bioavailability in silico – ident: 10.1016/j.tiv.2017.11.016_bb0120 – year: 2017 ident: 10.1016/j.tiv.2017.11.016_bb0005 article-title: Chemical toxicity prediction for major classes of industrial chemicals: is it possible to develop universal models covering cosmetics, drugs, and pesticides? publication-title: Food Chem. Toxicol. – volume: 148 start-page: 121 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0680 article-title: Incorporating high-throughput exposure predictions with dosimetry-adjusted in vitro bioactivity to inform chemical toxicity testing publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfv171 – volume: 309 start-page: 1 year: 2009 ident: 10.1016/j.tiv.2017.11.016_bb0180 article-title: Regulation (EC) No. 1107/2009 of the European parliament and of the council concerning the placing of plant protection products on the market and repealing Council Directives 79/117/EEC and 91/414/EEC publication-title: Off. J. Eur. Union – year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0035 – volume: 4 start-page: 226 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0645 article-title: Application of physiologically based pharmacokinetic (PBPK) modeling to support dose selection: report of an FDA public workshop on PBPK publication-title: CPT Pharmacomet. Syst. Pharmacol. doi: 10.1002/psp4.33 – volume: 2 year: 2011 ident: 10.1016/j.tiv.2017.11.016_bb0385 article-title: MEGen: a physiologically based pharmacokinetic model generator publication-title: Front. Pharmacol. doi: 10.3389/fphar.2011.00056 – volume: 30 start-page: 217 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0335 article-title: Biokinetics in repeated-dosing in vitro drug toxicity studies publication-title: Toxicol. in Vitro doi: 10.1016/j.tiv.2015.09.005 – volume: 77 start-page: 273 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0070 article-title: Modification of a PAMPA model to predict passive gastrointestinal absorption and plasma protein binding publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2015.06.023 – volume: 48 start-page: 9770 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0020 article-title: Application of mass balance models and the chemical activity concept to facilitate the use of in vitro toxicity data for risk assessment. Enviro publication-title: Sci. Technol. doi: 10.1021/es501955g – volume: 33 start-page: 1064 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0470 article-title: A physiologically-based pharmacokinetic model for disposition of 2,3,7,8-TCDD in fathead minnow and medaka publication-title: Environ. Toxicol. Chem. doi: 10.1002/etc.2504 – volume: 133 start-page: 320 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0400 article-title: Evaluation of perturbations in serum thyroid hormones during human pregnancy due to dietary iodide and perchlorate exposure using a biologically based dose-response model publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kft078 – volume: 96 start-page: 589 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0705 article-title: Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity publication-title: Clin. Pharmacol. Ther. doi: 10.1038/clpt.2014.158 – volume: 349 start-page: 1157 year: 2003 ident: 10.1016/j.tiv.2017.11.016_bb0310 article-title: Developmental pharmacology--drug disposition, action, and therapy in infants and children publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra035092 – volume: 27 start-page: 1570 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0115 article-title: Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches publication-title: Toxicol. in Vitro doi: 10.1016/j.tiv.2012.06.012 – year: 2011 ident: 10.1016/j.tiv.2017.11.016_bb0425 – volume: 45 start-page: 209 year: 2017 ident: 10.1016/j.tiv.2017.11.016_bb9000 article-title: Theoretical and mathematical foundation of the virtual cell based assay - a review publication-title: Toxicol. in Vitro doi: 10.1016/j.tiv.2016.07.013 – volume: 29 start-page: 903 year: 1995 ident: 10.1016/j.tiv.2017.11.016_bb0355 article-title: In vitro/in vivo correlations publication-title: Drug Inf. J. doi: 10.1177/009286159502900312 – volume: 2 year: 2011 ident: 10.1016/j.tiv.2017.11.016_bb0415 article-title: A workflow for global sensitivity analysis of PBPK models publication-title: Predict. Toxicol. – volume: 81 start-page: 67350 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0155 article-title: Request for public comments to be sent to EPA on peer review materials to inform the safe drinking water act decision making on perchlorate publication-title: Fed. Regist. – volume: 53 start-page: 625 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0540 article-title: A re-evaluation and validation of ontogeny functions for cytochrome P450 1A2 and 3A4 based on in vivo data publication-title: Clin. Pharmacokinet. doi: 10.1007/s40262-014-0140-7 – volume: 32 start-page: 3785 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0625 article-title: Predicting clearance mechanism in drug discovery: extended clearance classification system (ECCS) publication-title: Pharm. Res. doi: 10.1007/s11095-015-1749-4 – volume: 6 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0030 article-title: Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease publication-title: Sci. Rep. doi: 10.1038/srep25187 – year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0725 article-title: Using physiologically based pharmacokinetic modeling for in vitro in vivo extrapolation to predict chemical exposure [Poster] – volume: 101 start-page: 3989 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0560 article-title: A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes publication-title: J. Pharm. Sci. doi: 10.1002/jps.23262 – volume: 11 year: 2009 ident: 10.1016/j.tiv.2017.11.016_bb0100 article-title: Prediction of hepatic clearance in human from in vitro data for successful drug development publication-title: AAPS J. doi: 10.1208/s12248-009-9103-6 – volume: 35 start-page: 389 year: 2005 ident: 10.1016/j.tiv.2017.11.016_bb0135 article-title: Estimation of pharmacokinetic parameters from non-compartmental variables using Microsoft Excel publication-title: Comput. Biol. Med. doi: 10.1016/j.compbiomed.2004.02.008 – volume: 80 start-page: 35350 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0145 article-title: Use of high throughput assays and computational tools; endocrine disruptor screening program; notice of availability and opportunity for comment publication-title: Fed. Regist. – volume: 146 start-page: 348 year: 2007 ident: 10.1016/j.tiv.2017.11.016_bb0665 article-title: What is normal? A characterization of the values and variability in reproductive endpoints of the fathead minnow, Pimephales promelas publication-title: Comp. Biochem. Physiol. C: Toxicol. Pharmacol. – start-page: 441 year: 2014 ident: 10.1016/j.tiv.2017.11.016_bb0190 article-title: In vitro approaches to study drug–drug interactions – volume: 45 start-page: 469 year: 2004 ident: 10.1016/j.tiv.2017.11.016_bb0010 article-title: Small fish models for identifying and assessing the effects of endocrine-disrupting chemicals publication-title: ILAR J. doi: 10.1093/ilar.45.4.469 – volume: 51 start-page: 45 year: 2011 ident: 10.1016/j.tiv.2017.11.016_bb0530 article-title: Physiologically-based pharmacokinetics in drug development and regulatory science publication-title: Annu. Rev. Pharmacol. Toxicol. doi: 10.1146/annurev-pharmtox-010510-100540 – volume: 13 start-page: 1195 year: 1994 ident: 10.1016/j.tiv.2017.11.016_bb0365 article-title: Modeling the accumulation of three waterborne chlorinated ethanes in fathead minnows (Pimephales promelas): a physiologically based approach publication-title: Environ. Toxicol. Chem. doi: 10.1002/etc.5620130721 – ident: 10.1016/j.tiv.2017.11.016_bb0445 – volume: 13 start-page: 242 year: 2010 ident: 10.1016/j.tiv.2017.11.016_bb0040 article-title: Biokinetic modeling and in vitro–in vivo extrapolations publication-title: J. Toxicol. Environ. Health doi: 10.1080/10937404.2010.483940 – volume: 152 start-page: 230 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0140 article-title: Integration of life-stage physiologically based pharmacokinetic models with adverse outcome pathways and environmental exposure models to screen for environmental hazards publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfw082 – volume: 101 start-page: 2645 year: 2012 ident: 10.1016/j.tiv.2017.11.016_bb0245 article-title: Evaluation of hepatic clearance prediction using in vitro data: emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs publication-title: J. Pharm. Sci. doi: 10.1002/jps.23202 – volume: 117 start-page: 348 year: 2010 ident: 10.1016/j.tiv.2017.11.016_bb0525 article-title: Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfq220 – volume: 81 start-page: 406 year: 2007 ident: 10.1016/j.tiv.2017.11.016_bb0230 article-title: In vitro-in vivo correlation of hepatobiliary drug clearance in humans publication-title: Clin. Pharmacol. Ther. doi: 10.1038/sj.clpt.6100059 – volume: 33 start-page: 618 year: 2017 ident: 10.1016/j.tiv.2017.11.016_bb0195 article-title: tcpl: The ToxCast pipeline for high-throughput screening data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw680 – volume: 106 start-page: 433 year: 1990 ident: 10.1016/j.tiv.2017.11.016_bb0440 article-title: A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/0041-008X(90)90338-U – volume: 55 start-page: 50 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0130 article-title: Estimation of in vivo dose of dermally applied chemicals leading to estrogen/androgen receptor-mediated toxicity from in vitro data--illustration with four reproductive toxicants publication-title: Reprod. Toxicol. doi: 10.1016/j.reprotox.2015.01.002 – volume: 147 start-page: 55 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0655 article-title: Toxicokinetic triage for environmental chemicals publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfv118 – volume: 249 start-page: 197 year: 2010 ident: 10.1016/j.tiv.2017.11.016_bb0505 article-title: A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2010.09.010 – volume: 1 start-page: 10 year: 2013 ident: 10.1016/j.tiv.2017.11.016_bb0125 article-title: A framework incorporating the impact of exposure scenarios and application conditions on risk assessment of chemicals applied to skin publication-title: In Silico Pharmacol. doi: 10.1186/2193-9616-1-10 – volume: 6 year: 2015 ident: 10.1016/j.tiv.2017.11.016_bb0405 article-title: Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system publication-title: Front. Pharmacol. doi: 10.3389/fphar.2015.00107 – volume: 82 start-page: 164 year: 2004 ident: 10.1016/j.tiv.2017.11.016_bb0420 article-title: Accumulation of PBDE-47 in primary cultures of rat neocortical cells publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfh239 – year: 2017 ident: 10.1016/j.tiv.2017.11.016_bb0535 article-title: Automated workflows for modelling chemical fate, kinetics and toxicity [published online ahead of print 18 March 2017] publication-title: Toxicol. in Vitro doi: 10.1016/j.tiv.2017.03.004 – volume: 30 start-page: 1197 year: 2017 ident: 10.1016/j.tiv.2017.11.016_bb0200 article-title: Modeling exposure in the Tox21 in vitro bioassays publication-title: Chem. Res. Toxicol. doi: 10.1021/acs.chemrestox.7b00023 – volume: 50 start-page: 4579 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0590 article-title: Completing the link between exposure science and toxicology for improved environmental health decision making: the aggregate exposure pathway framework publication-title: Environ. Sci. Technol. doi: 10.1021/acs.est.5b05311 – start-page: 338 year: 2016 ident: 10.1016/j.tiv.2017.11.016_bb0475 article-title: Computer models for predicting drug absorption
SSID	ssj0005820
Score	2.5813775
SecondaryResourceType	review_article
Snippet	In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To...
SourceID	pubmedcentral proquest pubmed crossref elsevier
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	213
SubjectTerms	Animal Use Alternatives - trends Animals Assessments Biocompatibility Case studies Chemical Safety - instrumentation Chemical Safety - legislation & jurisprudence Chemical Safety - methods Chemical Safety - trends Computational Biology Computational toxicology Computer Simulation Decision making Decision Making, Computer-Assisted Decision Making, Organizational Environmental protection Expert Systems Extrapolation Guidelines as Topic Health Priorities - trends Health risks High throughput testing High-Throughput Screening Assays - trends Humans In vitro methods and tests In vivo methods and tests IVIVE Models, Biological National Institute of Environmental Health Sciences (U.S.) Organic chemistry R&D Research & development Risk assessment Safety System effectiveness Toxicity Toxicity testing Toxicity Tests - instrumentation Toxicity Tests - methods Toxicity Tests - trends Toxicokinetic Toxicology United States United States Dept. of Health and Human Services United States Environmental Protection Agency
Title	In vitro to in vivo extrapolation for high throughput prioritization and decision making
URI	https://dx.doi.org/10.1016/j.tiv.2017.11.016 https://www.ncbi.nlm.nih.gov/pubmed/29203341 https://www.proquest.com/docview/2067365440 https://www.proquest.com/docview/1973025088 https://pubmed.ncbi.nlm.nih.gov/PMC7393693
Volume	47
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9RAEB9K-6AgYutXtC0rSB-k6WWzm2zyWI6Wq2Ip2MK9LZvsHkY0Oe5yBV_8253JJteeSh98y8ckbDKzM79NZn4D8N4YThWZSZjkkQhlxtPQpAUPhbQRt8aqJKbi5M-X6eRGfpwm0y0YD7UwlFbZ-37v0ztv3R8Z9W9zNK-q0ReaH7EQGADJDXdLICkVWfnJr3tpHpmnZqTJRNLDn80uxws9CmV3qRMi8qSW5_-OTX9jzz9TKO_FpPNn8LQHk-zUj3cXtly9B4_GQw-3PTi68szUP4_Z9V2h1fKYHbGrO85qFHziP98xX5X0HKYXNbut2kXD2oZVtH3bMPTjeIvGZ88xRLuMyI5Z3-pnvmrZfFE1xJLkazuZqS2zfRMf9qPre_UCbs7PrseTsG_CEJYIrtpQUmUttzJWDsGF4aI0JkZUWGYzg0udWZEbDG-Gq6hEiTQyswIRKE_LXJUFqkW8hO26qd1rYJlyJouUdY7n0hYuV5bPElG6LEqMimQA0fD6ddkzlFOjjO96SEX7plFjmjSGKxeNRwL4sL5k7uk5HhKWg071ho1pDB8PXbY_6F_3E3ypifVepImUUQDv1qdRu_S_xdSuWS01z9EyY0LAAbzy5rIeJDUJE4ggAlAbhrQWINrvzTN19bWj_yYOwzQXb_7vad7CY9zLfBrdPmy3i5U7QFzVFofdxDmEndOLT5PL30VmIt0
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Nb9NAEB2VcigSQlC-DAUWCXpAdeO11177wAEVqoR-qBKplNuytjfCCOwocYp64U_xB5nJrtMGUA9IvUXetePs7Mw8x2_eALzSmlNFZuzHWRD5IuWJr5Oc-5EoA17qUsYhFScfHSf9U_FxFI_W4FdXC0O0Shf7bUxfRGt3pOdWszepqt4n8o8wijABUhhOuGNWHpjzH_jcNns7eI9Gfh2G-x-Ge33ftRbwC4QMrS-oXpSXIpQGU6bmUaF1iFinSMcaAfw4zzQGbc1lUOCMJNDjHHEVT4pMFjl-WYTXvQE3BYYLapuw-_MSryS1WpDkvXR73avUBakMQxjRyeQuKYdSj_V_J8O_we6fnM1LSXD_Ltxx6JW9swt0D9ZMvQkbe13TuE3YPrFS2Oc7bHhR2TXbYdvs5EIkGyfetv8XMlsGdR9Gg5qdVe20YW3DKvp81jBMHHiJxtL1GMJrRurKzPUWmsxbNplWDcky2WJSpuuSla5rEPu-aLT1AE6vxTQPYb1uavMYWCqNTgNZGsMzUeYmkyUfx1Fh0iDWMhAeBN3yq8JJolNnjm-q4759VWgxRRbDRyWFRzx4szxlYvVArposOpuqlU2tMF9dddpWZ3_lIspMkcx-lMRCBB68XA6jdekFj65NM58pnqErhAS5PXhkt8vyJqkrWYSQxQO5spGWE0hnfHWkrr4s9MZJNDHJoif_92tewEZ_eHSoDgfHB0_hFo6klsO3BevtdG6eIahr8-cLJ2Lw-bq99jf4I10X
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=In+vitro+to+in+vivo+extrapolation+for+high+throughput+prioritization+and+decision+making&rft.jtitle=Toxicology+in+vitro&rft.au=Bell%2C+Shannon+M&rft.au=Chang%2C+Xiaoqing&rft.au=Wambaugh%2C+John+F&rft.au=Allen%2C+David+G&rft.date=2018-03-01&rft.pub=Elsevier+Science+Ltd&rft.issn=0887-2333&rft.eissn=1879-3177&rft.volume=47&rft.spage=213&rft_id=info:doi/10.1016%2Fj.tiv.2017.11.016&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0887-2333&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0887-2333&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0887-2333&client=summon