The cell biology of the retinal pigment epithelium

The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that c...

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Published inProgress in retinal and eye research Vol. 78; p. 100846
Main Authors Lakkaraju, Aparna, Umapathy, Ankita, Tan, Li Xuan, Daniele, Lauren, Philp, Nancy J., Boesze-Battaglia, Kathleen, Williams, David S.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2020
Subjects
Autophagy
Endosomes
Lysosomes
Metabolism
Organelles
Phagocytosis
Phagosome maturation
Phagosome maturation
Lysosomes
Metabolism
Autophagy
Organelles
Phagocytosis
Endosomes
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Abstract The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology of the RPE. In recent years, new technologies such as live-cell imaging have resulted in major advancement in our understanding of areas such as the daily phagocytosis and clearance of photoreceptor outer segment tips, autophagy, endolysosome function, and the metabolic interplay between the RPE and photoreceptors. In this review, we aim to integrate these studies with an emphasis on appropriate models and techniques to investigate RPE cell biology and metabolism, and discuss how RPE cell biology informs our understanding of retinal disease.
AbstractList The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology of the RPE. In recent years, new technologies such as live-cell imaging have resulted in major advancement in our understanding of areas such as the daily phagocytosis and clearance of photoreceptor outer segment tips, autophagy, endolysosome function, and the metabolic interplay between the RPE and photoreceptors. In this review, we aim to integrate these studies with an emphasis on appropriate models and techniques to investigate RPE cell biology and metabolism, and discuss how RPE cell biology informs our understanding of retinal disease.
The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology of the RPE. In recent years, new technologies such as live-cell imaging have resulted in major advancement in our understanding of areas such as the daily phagocytosis and clearance of photoreceptor outer segment tips, autophagy, endolysosome function, and the metabolic interplay between the RPE and photoreceptors. In this review, we aim to integrate these studies with an emphasis on appropriate models and techniques to investigate RPE cell biology and metabolism, and discuss how RPE cell biology informs our understanding of retinal disease.The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology of the RPE. In recent years, new technologies such as live-cell imaging have resulted in major advancement in our understanding of areas such as the daily phagocytosis and clearance of photoreceptor outer segment tips, autophagy, endolysosome function, and the metabolic interplay between the RPE and photoreceptors. In this review, we aim to integrate these studies with an emphasis on appropriate models and techniques to investigate RPE cell biology and metabolism, and discuss how RPE cell biology informs our understanding of retinal disease.
ArticleNumber 100846
Author Philp, Nancy J.
Tan, Li Xuan
Williams, David S.
Umapathy, Ankita
Boesze-Battaglia, Kathleen
Lakkaraju, Aparna
Daniele, Lauren
AuthorAffiliation d Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
c Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
e Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
b Department of Ophthalmology and Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
a Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA
AuthorAffiliation_xml – name: b Department of Ophthalmology and Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
– name: a Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA
– name: d Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
– name: e Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
– name: c Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Author_xml – sequence: 1
  givenname: Aparna
  orcidid: 0000-0002-2869-7378
  surname: Lakkaraju
  fullname: Lakkaraju, Aparna
  organization: Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA
– sequence: 2
  givenname: Ankita
  surname: Umapathy
  fullname: Umapathy, Ankita
  organization: Department of Ophthalmology and Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
– sequence: 3
  givenname: Li Xuan
  surname: Tan
  fullname: Tan, Li Xuan
  organization: Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA
– sequence: 4
  givenname: Lauren
  surname: Daniele
  fullname: Daniele, Lauren
  organization: Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
– sequence: 5
  givenname: Nancy J.
  surname: Philp
  fullname: Philp, Nancy J.
  organization: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
– sequence: 6
  givenname: Kathleen
  surname: Boesze-Battaglia
  fullname: Boesze-Battaglia, Kathleen
  organization: Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
– sequence: 7
  givenname: David S.
  surname: Williams
  fullname: Williams, David S.
  email: dswilliams@ucla.edu
  organization: Department of Ophthalmology and Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32105772$$D View this record in MEDLINE/PubMed
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Lysosomes
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Autophagy
Organelles
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Endosomes
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Snippet The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the...
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SubjectTerms Autophagy
Endosomes
Lysosomes
Metabolism
Organelles
Phagocytosis
Phagosome maturation
Title The cell biology of the retinal pigment epithelium
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https://www.ncbi.nlm.nih.gov/pubmed/32105772
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