Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters

• Published in: Atherosclerosis Vol. 188; no. 2; pp. 425 - 432
• Main Authors: Hallikainen, Maarit, Lyyra-Laitinen, Tiina, Laitinen, Tomi, Ågren, Jyrki J., Pihlajamäki, Jussi, Rauramaa, Rainer, Miettinen, Tatu A., Gylling, Helena
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.10.2006; Elsevier
• Subjects: Adult; Aged; Anticholesteremic Agents - administration & dosage; Anticholesteremic Agents - pharmacology; Anticholesteremic Agents - therapeutic use; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood Chemical Analysis; Blood Pressure; Brachial Artery - diagnostic imaging; Cardiology. Vascular system; Cardiovascular system; Cholesterol; Cholesterol, HDL - blood; Cross-Over Studies; Dietary Fats - administration & dosage; Double-Blind Method; Endothelial function; Endothelium, Vascular - drug effects; Female; Finland; Humans; Hypercholesterolemia; Hypercholesterolemia - blood; Hypercholesterolemia - drug therapy; Hypercholesterolemia - physiopathology; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Plant stanols; Plant sterols; Sitosterols - administration & dosage; Sitosterols - pharmacology; Sitosterols - therapeutic use; Ultrasonography; Vasodilator agents. Cerebral vasodilators; Plant stanols; Hypercholesterolemia; Endothelial function; Plant sterols; Cholesterol; Human; Brachial artery; Metabolic diseases; Cardiovascular disease; Cholesterol LDL; Lipids; Hyperlipoproteinemia; Glucose; Lipoprotein; Triglyceride; Vascular disease; Cholesterol HDL; Dilatation; Atherosclerosis; Double blind study; Dyslipemia; Sterol

We investigated the effects of stanol (STAEST) and sterol esters (STEEST) on endothelial function in hypercholesterolemic subjects. In addition, associations of variables of cholesterol metabolism with endothelial function were investigated. In a double-blind randomized cross-over study ( n = 39) wi...