Epigenetic control of gene regulation during development and disease: A view from the retina

• Published in: Progress in retinal and eye research Vol. 65; pp. 1 - 27
• Main Authors: Corso-Díaz, Ximena, Jaeger, Catherine, Chaitankar, Vijender, Swaroop, Anand
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2018
• Subjects: Chromatin; DNA methylation; DNA Methylation - physiology; Epigenesis, Genetic - physiology; Epigenomics; Gene Expression Regulation - physiology; Gene Regulatory Networks - physiology; Histone modification; Humans; Macular Degeneration - genetics; Neuronal differentiation; Next generation sequencing; Photoreceptor; Retina - embryology; Retina - physiology; Retina neurodegeneration; RNA - metabolism; Chromatin; Photoreceptor; Retina neurodegeneration; DNA methylation; Neuronal differentiation; Histone modification; Next generation sequencing

Complex biological processes, such as organogenesis and homeostasis, are stringently regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates and/or to respond to the microenvironment. Gene regulatory networks that guide cell differentiation and function are mo...