Subcutaneous Adipose Tissue Macrophage Infiltration Is Associated With Hepatic and Visceral Fat Deposition, Hyperinsulinemia, and Stimulation of NF-κB Stress Pathway

• Published in: Diabetes (New York, N.Y.) Vol. 60; no. 11; pp. 2802 - 2809
• Main Authors: Lê, Kim-Anne, Mahurkar, Swapna, Alderete, Tanya L., Hasson, Rebecca E., Adam, Tanja C., Kim, Joon Sung, Beale, Elizabeth, Xie, Chen, Greenberg, Andrew S., Allayee, Hooman, Goran, Michael I.
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.11.2011
• Subjects: Adipose tissues; Adolescent; Adult; Cross-Sectional Studies; Fatty Liver - etiology; Female; Gene expression; Genetic aspects; Humans; Hyperglycemia - etiology; Hyperinsulinism - etiology; Inflammation Mediators - metabolism; Insulin Resistance; Insulin-Secreting Cells - metabolism; Intra-Abdominal Fat - pathology; Liver - metabolism; Liver - pathology; Macrophages; Macrophages - immunology; Macrophages - pathology; Male; Metabolic diseases; NF-kappa B - genetics; NF-kappa B - metabolism; Obesity - blood; Obesity - immunology; Obesity - pathology; Obesity - physiopathology; Obesity Studies; Oligonucleotide Array Sequence Analysis; Physiological aspects; Risk factors; Subcutaneous Fat - immunology; Subcutaneous Fat - metabolism; Subcutaneous Fat - pathology; Up-Regulation; Young Adult; United States

To examine in obese young adults the influence of ethnicity and subcutaneous adipose tissue (SAT) inflammation on hepatic fat fraction (HFF), visceral adipose tissue (VAT) deposition, insulin sensitivity (SI), β-cell function, and SAT gene expression. SAT biopsies were obtained from 36 obese young a...