Hub Genes in Non-Small Cell Lung Cancer Regulatory Networks

• Published in: Biomolecules (Basel, Switzerland) Vol. 12; no. 12; p. 1782
• Main Authors: Ye, Qing, Guo, Nancy Lan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.11.2022; MDPI
• Subjects: Algorithms; Annotations; Artificial intelligence; Biomarkers; Biomarkers, Tumor - genetics; Boolean; Cancer; Cancer therapies; Carcinogenesis; Carcinoma, Non-Small-Cell Lung - pathology; CD27 antigen; Chemotherapy; Clinical trials; Copy number; CRISPR; CRISPR-Cas9; CTLA-4 protein; Development and progression; DNA Copy Number Variations; Gene expression; Gene Regulatory Networks; Genetic aspects; Genomes; hub genes; Humans; Immunotherapy; Lung cancer; Lung cancer, Non-small cell; Lung Neoplasms - pathology; Medical prognosis; Metastasis; Methods; mRNA; multi-omics networks; non-small cell lung cancer; Non-small cell lung carcinoma; Patient outcomes; Patients; PD-1 protein; proliferation; Protein expression; Proteins; RNA-mediated interference; RNAi; Small cell lung carcinoma; Therapeutic applications; Therapeutic targets; Tumorigenesis; Tumors; United States; non-small cell lung cancer; RNAi; patient survival; proliferation; CRISPR-Cas9; biomarkers; multi-omics networks; therapeutic targets; hub genes

There are currently no accurate biomarkers for optimal treatment selection in early-stage non-small cell lung cancer (NSCLC). Novel therapeutic targets are needed to improve NSCLC survival outcomes. This study systematically evaluated the association between genome-scale regulatory network centralit...