Fighting Oxidative Stress with Sulfur: Hydrogen Sulfide in the Renal and Cardiovascular Systems

Hydrogen sulfide (H2S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration and cysteine catabolism pathways can occur in the kidneys and blood vessels. Fu...

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Published inAntioxidants Vol. 10; no. 3; p. 373
Main Authors Scammahorn, Joshua J., Nguyen, Isabel T. N., Bos, Eelke M., Van Goor, Harry, Joles, Jaap A.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 02.03.2021
MDPI
Subjects
Age
Animal models
animals
Antioxidants
blood
Blood vessels
cardiorenal syndrome
Cardiovascular system
catabolism
Cell therapy
Cysteine
Cytochrome
Disease
Enzymes
H2S donors
Heart
Homeostasis
Homocysteine
Hydrogen
Hydrogen sulfide
Hypoxia-inducible factor 1a
Immunosuppressive agents
Kidneys
Laboratory animals
Metabolism
Mitochondria
NF-κB protein
Nonsteroidal anti-inflammatory drugs
Oxidants
Oxidative stress
Proteins
Reactive oxygen species
Review
Signal transduction
Stem cells
Sulfur
Therapeutic applications
therapeutics
thiosulfate
Transplantation
hydrogen sulfide
thiosulfate
H2S donors
reactive oxygen species
cardiorenal syndrome
Online AccessGet full text
ISSN2076-3921
2076-3921
DOI10.3390/antiox10030373

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Abstract Hydrogen sulfide (H2S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration and cysteine catabolism pathways can occur in the kidneys and blood vessels. Furthermore, non-enzymatic pathways are present throughout the body. In the renal and cardiovascular system, H2S plays an important role in maintaining the redox status at safe levels by promoting scavenging of reactive oxygen species (ROS). H2S also modifies cysteine residues on key signaling molecules such as keap1/Nrf2, NFκB, and HIF-1α, thereby promoting anti-oxidant mechanisms. Depletion of H2S is implicated in many age-related and cardiorenal diseases, all having oxidative stress as a major contributor. Current research suggests potential for H2S-based therapies, however, therapeutic interventions have been limited to studies in animal models. Beyond H2S use as direct treatment, it could improve procedures such as transplantation, stem cell therapy, and the safety and efficacy of drugs including NSAIDs and ACE inhibitors. All in all, H2S is a prime subject for further research with potential for clinical use.
AbstractList Hydrogen sulfide (H2S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration and cysteine catabolism pathways can occur in the kidneys and blood vessels. Furthermore, non-enzymatic pathways are present throughout the body. In the renal and cardiovascular system, H2S plays an important role in maintaining the redox status at safe levels by promoting scavenging of reactive oxygen species (ROS). H2S also modifies cysteine residues on key signaling molecules such as keap1/Nrf2, NFκB, and HIF-1α, thereby promoting anti-oxidant mechanisms. Depletion of H2S is implicated in many age-related and cardiorenal diseases, all having oxidative stress as a major contributor. Current research suggests potential for H2S-based therapies, however, therapeutic interventions have been limited to studies in animal models. Beyond H2S use as direct treatment, it could improve procedures such as transplantation, stem cell therapy, and the safety and efficacy of drugs including NSAIDs and ACE inhibitors. All in all, H2S is a prime subject for further research with potential for clinical use.
Hydrogen sulfide (H S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration and cysteine catabolism pathways can occur in the kidneys and blood vessels. Furthermore, non-enzymatic pathways are present throughout the body. In the renal and cardiovascular system, H S plays an important role in maintaining the redox status at safe levels by promoting scavenging of reactive oxygen species (ROS). H S also modifies cysteine residues on key signaling molecules such as keap1/Nrf2, NFκB, and HIF-1α, thereby promoting anti-oxidant mechanisms. Depletion of H S is implicated in many age-related and cardiorenal diseases, all having oxidative stress as a major contributor. Current research suggests potential for H S-based therapies, however, therapeutic interventions have been limited to studies in animal models. Beyond H S use as direct treatment, it could improve procedures such as transplantation, stem cell therapy, and the safety and efficacy of drugs including NSAIDs and ACE inhibitors. All in all, H S is a prime subject for further research with potential for clinical use.
Hydrogen sulfide (H2S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration and cysteine catabolism pathways can occur in the kidneys and blood vessels. Furthermore, non-enzymatic pathways are present throughout the body. In the renal and cardiovascular system, H2S plays an important role in maintaining the redox status at safe levels by promoting scavenging of reactive oxygen species (ROS). H2S also modifies cysteine residues on key signaling molecules such as keap1/Nrf2, NFκB, and HIF-1α, thereby promoting anti-oxidant mechanisms. Depletion of H2S is implicated in many age-related and cardiorenal diseases, all having oxidative stress as a major contributor. Current research suggests potential for H2S-based therapies, however, therapeutic interventions have been limited to studies in animal models. Beyond H2S use as direct treatment, it could improve procedures such as transplantation, stem cell therapy, and the safety and efficacy of drugs including NSAIDs and ACE inhibitors. All in all, H2S is a prime subject for further research with potential for clinical use.Hydrogen sulfide (H2S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration and cysteine catabolism pathways can occur in the kidneys and blood vessels. Furthermore, non-enzymatic pathways are present throughout the body. In the renal and cardiovascular system, H2S plays an important role in maintaining the redox status at safe levels by promoting scavenging of reactive oxygen species (ROS). H2S also modifies cysteine residues on key signaling molecules such as keap1/Nrf2, NFκB, and HIF-1α, thereby promoting anti-oxidant mechanisms. Depletion of H2S is implicated in many age-related and cardiorenal diseases, all having oxidative stress as a major contributor. Current research suggests potential for H2S-based therapies, however, therapeutic interventions have been limited to studies in animal models. Beyond H2S use as direct treatment, it could improve procedures such as transplantation, stem cell therapy, and the safety and efficacy of drugs including NSAIDs and ACE inhibitors. All in all, H2S is a prime subject for further research with potential for clinical use.
Hydrogen sulfide (H 2 S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration and cysteine catabolism pathways can occur in the kidneys and blood vessels. Furthermore, non-enzymatic pathways are present throughout the body. In the renal and cardiovascular system, H 2 S plays an important role in maintaining the redox status at safe levels by promoting scavenging of reactive oxygen species (ROS). H 2 S also modifies cysteine residues on key signaling molecules such as keap1/Nrf2, NFκB, and HIF-1α, thereby promoting anti-oxidant mechanisms. Depletion of H 2 S is implicated in many age-related and cardiorenal diseases, all having oxidative stress as a major contributor. Current research suggests potential for H 2 S-based therapies, however, therapeutic interventions have been limited to studies in animal models. Beyond H 2 S use as direct treatment, it could improve procedures such as transplantation, stem cell therapy, and the safety and efficacy of drugs including NSAIDs and ACE inhibitors. All in all, H 2 S is a prime subject for further research with potential for clinical use.
Hydrogen sulfide (H₂S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration and cysteine catabolism pathways can occur in the kidneys and blood vessels. Furthermore, non-enzymatic pathways are present throughout the body. In the renal and cardiovascular system, H₂S plays an important role in maintaining the redox status at safe levels by promoting scavenging of reactive oxygen species (ROS). H₂S also modifies cysteine residues on key signaling molecules such as keap1/Nrf2, NFκB, and HIF-1α, thereby promoting anti-oxidant mechanisms. Depletion of H₂S is implicated in many age-related and cardiorenal diseases, all having oxidative stress as a major contributor. Current research suggests potential for H₂S-based therapies, however, therapeutic interventions have been limited to studies in animal models. Beyond H₂S use as direct treatment, it could improve procedures such as transplantation, stem cell therapy, and the safety and efficacy of drugs including NSAIDs and ACE inhibitors. All in all, H₂S is a prime subject for further research with potential for clinical use.
Author Scammahorn, Joshua J.
Bos, Eelke M.
Joles, Jaap A.
Nguyen, Isabel T. N.
Van Goor, Harry
AuthorAffiliation 2 Department of Neurosurgery, Erasmus Medical Center Rotterdam, 3015 CN Rotterdam, The Netherlands; e.bos@erasmusmc.nl
3 Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, 9713 GZ Groningen, The Netherlands
1 Department of Nephrology & Hypertension, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands; j.j.scammahorn@umcutrecht.nl (J.J.S.); T.N.Nguyen-4@umcutrecht.nl (I.T.N.N.); J.A.Joles@umcutrecht.nl (J.A.J.)
AuthorAffiliation_xml – name: 3 Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, 9713 GZ Groningen, The Netherlands
– name: 1 Department of Nephrology & Hypertension, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands; j.j.scammahorn@umcutrecht.nl (J.J.S.); T.N.Nguyen-4@umcutrecht.nl (I.T.N.N.); J.A.Joles@umcutrecht.nl (J.A.J.)
– name: 2 Department of Neurosurgery, Erasmus Medical Center Rotterdam, 3015 CN Rotterdam, The Netherlands; e.bos@erasmusmc.nl
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– sequence: 2
  givenname: Isabel T. N.
  surname: Nguyen
  fullname: Nguyen, Isabel T. N.
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  givenname: Eelke M.
  orcidid: 0000-0003-3647-6740
  surname: Bos
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  givenname: Jaap A.
  orcidid: 0000-0003-2565-242X
  surname: Joles
  fullname: Joles, Jaap A.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33801446$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords hydrogen sulfide
thiosulfate
H2S donors
reactive oxygen species
cardiorenal syndrome
Language English
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Snippet Hydrogen sulfide (H2S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded....
Hydrogen sulfide (H S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded....
Hydrogen sulfide (H₂S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded....
Hydrogen sulfide (H 2 S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly...
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StartPage 373
SubjectTerms Age
Animal models
animals
Antioxidants
blood
Blood vessels
cardiorenal syndrome
Cardiovascular system
catabolism
Cell therapy
Cysteine
Cytochrome
Disease
Enzymes
H2S donors
Heart
Homeostasis
Homocysteine
Hydrogen
Hydrogen sulfide
Hypoxia-inducible factor 1a
Immunosuppressive agents
Kidneys
Laboratory animals
Metabolism
Mitochondria
NF-κB protein
Nonsteroidal anti-inflammatory drugs
Oxidants
Oxidative stress
Proteins
Reactive oxygen species
Review
Signal transduction
Stem cells
Sulfur
Therapeutic applications
therapeutics
thiosulfate
Transplantation
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Title Fighting Oxidative Stress with Sulfur: Hydrogen Sulfide in the Renal and Cardiovascular Systems
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Volume 10
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