Predicting breast cancer response to neoadjuvant chemotherapy using pretreatment diffuse optical spectroscopic texture analysis

• Published in: British journal of cancer Vol. 116; no. 10; pp. 1329 - 1339
• Main Authors: Tran, William T, Gangeh, Mehrdad J, Sannachi, Lakshmanan, Chin, Lee, Watkins, Elyse, Bruni, Silvio G, Rastegar, Rashin Fallah, Curpen, Belinda, Trudeau, Maureen, Gandhi, Sonal, Yaffe, Martin, Slodkowska, Elzbieta, Childs, Charmaine, Sadeghi-Naini, Ali, Czarnota, Gregory J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.05.2017; Nature Publishing Group
• Subjects: 631/1647/527; 692/53/2423; 692/699/67/1059/99; 692/699/67/1347; Accuracy; Anthracyclines - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Area Under Curve; Biomedical and Life Sciences; Biomedicine; Breast cancer; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Bridged-Ring Compounds - administration & dosage; Cancer Research; Cancer therapies; Carcinoma, Ductal, Breast - diagnostic imaging; Carcinoma, Ductal, Breast - drug therapy; Carcinoma, Ductal, Breast - pathology; Carcinoma, Lobular - drug therapy; Carcinoma, Lobular - pathology; Chemotherapy; Chemotherapy, Adjuvant; Drug Resistance; Epidemiology; Female; Health sciences; Hemoglobin; Hemoglobins - metabolism; Humans; Magnetic resonance imaging; Mammography; Medical imaging; Medical research; Middle Aged; Molecular Medicine; Neoadjuvant Therapy; Oncology; Oxygen - metabolism; Predictive Value of Tests; Radiation; ROC Curve; Spectrum Analysis; Taxoids - administration & dosage; Tomography, Optical - methods; Translational Therapeutics; Trastuzumab - administration & dosage; Tumor Burden; Tumors; United Kingdom > UK; Toronto Ontario Canada; Canada; imaging biomarkers; diffuse optical spectroscopy imaging; breast cancer

Background: Diffuse optical spectroscopy (DOS) has been demonstrated capable of monitoring response to neoadjuvant chemotherapy (NAC) in locally advanced breast cancer (LABC) patients. In this study, we evaluate texture features of pretreatment DOS functional maps for predicting LABC response to NAC...