Gut immune system and oral tolerance

• Published in: British journal of nutrition Vol. 109; no. S2; pp. S3 - S11
• Main Authors: Castro-Sánchez, Patricia, Martín-Villa, José M.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.01.2013
• Subjects: Animal diseases; Animals; Antigen presentation; antigens; Autoimmune diseases; bacteria; Biological and medical sciences; CD4-positive T-lymphocytes; cytokines; digestive system; Feeding. Feeding behavior; Flora; Fundamental and applied biological sciences. Psychology; Gastrointestinal Tract - immunology; Humans; Immune response; Immune system; Immune Tolerance; Immunity, Mucosal; immunomodulation; laboratory animals; Lymphocytes; Lymphoid Tissue - immunology; mucosa; Pathogens; T-Lymphocytes, Regulatory - immunology; Tissues; transforming growth factor beta; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Mucosal immunity; Oral immunisation; Mucosa-associated lymphoid tissue; Regulatory T cells; Nutrition; Digestive system; Mucosa; Gut; Oral administration; Tolerance; Lymphoid tissue; Immunity; T-Lymphocyte; Immune system

Gut mucosal surfaces separate the external environment from the internal sterile environment and so represent a first line of defence system. This barrier faces environments rich in pathogens that have developed effective mechanisms for colonisation of epithelial surfaces and invasion of mucosal tis...