Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension

• Published in: Biophysical journal Vol. 110; no. 1; pp. 34 - 43
• Main Authors: Arsenovic, Paul T., Ramachandran, Iswarya, Bathula, Kranthidhar, Zhu, Ruijun, Narang, Jiten D., Noll, Natalie A., Lemmon, Christopher A., Gundersen, Gregg G., Conway, Daniel E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.01.2016; Biophysical Society; The Biophysical Society
• Subjects: Animals; Biomechanical Phenomena; Biosensors; Cell Nucleus - metabolism; Cytoskeleton; Energy transfer; Fibroblasts - cytology; Fibroblasts - metabolism; Fluorescence; Geometry; Humans; Mechanical Phenomena; Mice; Movement; Myosins - metabolism; Nerve Tissue Proteins - metabolism; NIH 3T3 Cells; Nuclear Proteins - metabolism; Nucleic Acids and Genome Biophysics; Proteins; Tension

The nucleus of a cell has long been considered to be subject to mechanical force. Despite the observation that mechanical forces affect nuclear geometry and movement, how forces are applied onto the nucleus is not well understood. The nuclear LINC (linker of nucleoskeleton and cytoskeleton) complex...