Not quite PIB-positive, not quite PIB-negative: Slight PIB elevations in elderly normal control subjects are biologically relevant

• Published in: NeuroImage (Orlando, Fla.) Vol. 59; no. 2; pp. 1152 - 1160
• Main Authors: Mormino, Elizabeth C., Brandel, Michael G., Madison, Cindee M., Rabinovici, Gil D., Marks, Shawn, Baker, Suzanne L., Jagust, William J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.01.2012; Elsevier Limited
• Subjects: Adult; Age; Aged; Aged, 80 and over; Aging; Aging - metabolism; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer's disease; Alzheimer's disease (AD); Aniline Compounds; Benzothiazoles - pharmacokinetics; Beta-amyloid; Brain - diagnostic imaging; Brain - metabolism; Female; Humans; Male; Medical imaging; Middle Aged; NMR; Nuclear magnetic resonance; PIB-PET imaging; PIB-positivity; Positron-Emission Tomography - methods; Preclinical AD; Radiopharmaceuticals - pharmacokinetics; Reproducibility of Results; Sensitivity and Specificity; Studies; Thiazoles; Tissue Distribution; Young Adult; Aging; Alzheimer's disease (AD); Preclinical AD; PIB-positivity; PIB-PET imaging; Beta-amyloid
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2011.07.098

Researchers employing Pittsburgh Compound B positron emission tomography (PIB-PET) imaging have consistently indentified old normal control (oNC) subjects with elevated tracer uptake, suggesting the presence of beta-amyloid deposition in these individuals. However, a consensus regarding the level at...