Targeting presynaptic norepinephrine transporter in brown adipose tissue: A novel imaging approach and potential treatment for diabetes and obesity

• Published in: Synapse (New York, N.Y.) Vol. 67; no. 2; pp. 79 - 93
• Main Authors: Mirbolooki, M. Reza, Constantinescu, Cristian C., Pan, Min-Liang, Mukherjee, Jogeshwar
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2013; Wiley Subscription Services, Inc
• Subjects: 18F-FDG PET; Adipose Tissue, Brown - diagnostic imaging; Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - metabolism; Adrenergic beta-Antagonists - pharmacology; Adrenergic Uptake Inhibitors - pharmacology; Animals; atomoxetine; Atomoxetine Hydrochloride; blood glucose; Blood Glucose - metabolism; Brown fat; Diabetes Mellitus, Type 2 - metabolism; Fluorodeoxyglucose F18 - pharmacology; Male; Norepinephrine Plasma Membrane Transport Proteins - metabolism; Obesity - metabolism; Propranolol - pharmacology; Propylamines - pharmacology; Radionuclide Imaging; Rats; Rats, Sprague-Dawley

Brown adipose tissue (BAT) plays a significant role in metabolism. In this study, we report the use of atomoxetine (a clinically applicable norepinephrine reuptake inhibitor) for 18F‐FDG PET imaging of BAT and its effects on heat production and blood glucose concentration. Fasted‐male Sprague‐Dawley...