Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome

• Published in: Journal of comparative neurology (1911) Vol. 518; no. 3; pp. 277 - 291
• Main Authors: Kataoka, Yuko, Kalanithi, Paul S.A., Grantz, Heidi, Schwartz, Michael L., Saper, Clifford, Leckman, James F., Vaccarino, Flora M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2010; Wiley Subscription Services, Inc
• Subjects: acetylcholine; Acetylcholine - metabolism; Adult; Aged; Biomarkers - metabolism; Caudate Nucleus - metabolism; Caudate Nucleus - pathology; Caudate Nucleus - physiopathology; Cell Count; Cell Death - physiology; Cell Shape - physiology; Choline O-Acetyltransferase - metabolism; Corpus Striatum - metabolism; Corpus Striatum - pathology; Corpus Striatum - physiopathology; Humans; Interneurons - metabolism; Interneurons - pathology; Male; Middle Aged; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Nerve Degeneration - physiopathology; parvalbumin; Parvalbumins - metabolism; postmortem; Putamen - metabolism; Putamen - pathology; Putamen - physiopathology; striatum; Tourette syndrome; Tourette Syndrome - metabolism; Tourette Syndrome - pathology; Tourette Syndrome - physiopathology
• ISSN: 0021-9967; 1096-9861; 1096-9861
• DOI: 10.1002/cne.22206

Corticobasal ganglia neuronal ensembles bring automatic motor skills into voluntary control and integrate them into ongoing motor behavior. A 5% decrease in caudate (Cd) nucleus volume is the most consistent structural finding in the brain of patients with Tourette syndrome (TS), but the cellular ab...