Changes in impact of HLA class I allele expression on HIV-1 plasma virus loads at a population level over time

• Published in: Microbiology and immunology Vol. 54; no. 4; p. 196
• Main Authors: Koga, Michiko, Kawana-Tachikawa, Ai, Heckerman, David, Odawara, Takashi, Nakamura, Hitomi, Koibuchi, Tomohiko, Fujii, Takeshi, Miura, Toshiyuki, Iwamoto, Aikichi
• Format: Journal Article
• Language: English
• Published: Australia 01.04.2010
• Subjects: Alleles; CD4 Lymphocyte Count; Cross-Sectional Studies; Histocompatibility Antigens Class I - classification; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - immunology; Histocompatibility Antigens Class I - metabolism; Histocompatibility Testing; HIV Infections - immunology; HIV Infections - virology; HIV-1 - genetics; HIV-1 - immunology; HIV-1 - metabolism; HIV-1 - physiology; HLA-B Antigens - genetics; HLA-B Antigens - metabolism; HLA-B51 Antigen; Humans; Japan; Mutation; RNA, Viral - blood; T-Lymphocytes, Cytotoxic - immunology; T-Lymphocytes, Cytotoxic - metabolism; T-Lymphocytes, Cytotoxic - virology; Time Factors; Viral Load; Japan

HLA class I allele types have differential impacts on the level of the pVL and outcome of HIV-1 infection. While accumulations of CTL escape mutations at population levels have been reported, their actual impact on the level of the pVL remains unknown. In this study HLA class I types from 141 untrea...