Reproducibility of the Oral Glucose Tolerance Test in Overweight Children
Objective: We examined the reproducibility of the oral glucose tolerance test (OGTT) in overweight children and evaluated distinguishing characteristics between those with concordant vs. discordant results. Design: Sixty overweight youth (8–17 yr old) completed two OGTTs (interval between tests 1–25...
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| Published in | The journal of clinical endocrinology and metabolism Vol. 93; no. 11; pp. 4231 - 4237 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Bethesda, MD
Oxford University Press
01.11.2008
Copyright by The Endocrine Society Endocrine Society The Endocrine Society |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Objective: We examined the reproducibility of the oral glucose tolerance test (OGTT) in overweight children and evaluated distinguishing characteristics between those with concordant vs. discordant results.
Design: Sixty overweight youth (8–17 yr old) completed two OGTTs (interval between tests 1–25 d). Insulin sensitivity was assessed by the surrogate measures of fasting glucose to insulin ratio, whole-body insulin sensitivity index, and homeostasis model assessment of insulin resistance, and insulin secretion by the insulinogenic index with calculation of the glucose disposition index (GDI).
Results: Of the 10 subjects with impaired glucose tolerance (IGT) during the first OGTT only three (30%) had IGT during the second OGTT. The percent positive agreement between the first and second OGTT was low for both impaired fasting glucose and IGT (22.2 and 27.3%, respectively). Fasting blood glucose had higher reproducibility, compared with the 2-h glucose. Youth with discordant OGTTs, compared with those with concordant results, were more insulin resistant (glucose/insulin 2.7 ± 1.4 vs. 4.1 ± 1.8, P = 0.006, whole-body insulin sensitivity index of 1.3 ± 0.6 vs. 2.2 ± 1.1, P = 0.003, and homeostasis model assessment of insulin resistance 10.6± 8.1 vs. 5.7 ± 2.8, P = 0.001), had a lower GDI (0.45 ± 0.58 vs. 1.02 ± 1.0, P = 0.03), and had higher low-density lipoprotein cholesterol (117.7 ± 36.6 vs. 89.9 ± 20.1, P = 0.0005) without differences in physical characteristics.
Conclusions: Our results show poor reproducibility of the OGTT in obese youth, in particular for the 2-h plasma glucose. Obese youth who have discordant OGTT results are more insulin resistant with higher risk of developing type 2 diabetes mellitus, as evidenced by a lower GDI. The implications of this remain to be determined in clinical and research settings. |
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| AbstractList | OBJECTIVE:We examined the reproducibility of the oral glucose tolerance test (OGTT) in overweight children and evaluated distinguishing characteristics between those with concordant vs. discordant results.
DESIGN:Sixty overweight youth (8-17 yr old) completed two OGTTs (interval between tests 1-25 d). Insulin sensitivity was assessed by the surrogate measures of fasting glucose to insulin ratio, whole-body insulin sensitivity index, and homeostasis model assessment of insulin resistance, and insulin secretion by the insulinogenic index with calculation of the glucose disposition index (GDI).
RESULTS:Of the 10 subjects with impaired glucose tolerance (IGT) during the first OGTT only three (30%) had IGT during the second OGTT. The percent positive agreement between the first and second OGTT was low for both impaired fasting glucose and IGT (22.2 and 27.3%, respectively). Fasting blood glucose had higher reproducibility, compared with the 2-h glucose. Youth with discordant OGTTs, compared with those with concordant results, were more insulin resistant (glucose/insulin 2.7 ± 1.4 vs. 4.1 ± 1.8, P = 0.006, whole-body insulin sensitivity index of 1.3 ± 0.6 vs. 2.2 ± 1.1, P = 0.003, and homeostasis model assessment of insulin resistance 10.6± 8.1 vs. 5.7 ± 2.8, P = 0.001), had a lower GDI (0.45 ± 0.58 vs. 1.02 ± 1.0, P = 0.03), and had higher low-density lipoprotein cholesterol (117.7 ± 36.6 vs. 89.9 ± 20.1, P = 0.0005) without differences in physical characteristics.
CONCLUSIONS:Our results show poor reproducibility of the OGTT in obese youth, in particular for the 2-h plasma glucose. Obese youth who have discordant OGTT results are more insulin resistant with higher risk of developing type 2 diabetes mellitus, as evidenced by a lower GDI. The implications of this remain to be determined in clinical and research settings. We examined the reproducibility of the oral glucose tolerance test (OGTT) in overweight children and evaluated distinguishing characteristics between those with concordant vs. discordant results.OBJECTIVEWe examined the reproducibility of the oral glucose tolerance test (OGTT) in overweight children and evaluated distinguishing characteristics between those with concordant vs. discordant results.Sixty overweight youth (8-17 yr old) completed two OGTTs (interval between tests 1-25 d). Insulin sensitivity was assessed by the surrogate measures of fasting glucose to insulin ratio, whole-body insulin sensitivity index, and homeostasis model assessment of insulin resistance, and insulin secretion by the insulinogenic index with calculation of the glucose disposition index (GDI).DESIGNSixty overweight youth (8-17 yr old) completed two OGTTs (interval between tests 1-25 d). Insulin sensitivity was assessed by the surrogate measures of fasting glucose to insulin ratio, whole-body insulin sensitivity index, and homeostasis model assessment of insulin resistance, and insulin secretion by the insulinogenic index with calculation of the glucose disposition index (GDI).Of the 10 subjects with impaired glucose tolerance (IGT) during the first OGTT only three (30%) had IGT during the second OGTT. The percent positive agreement between the first and second OGTT was low for both impaired fasting glucose and IGT (22.2 and 27.3%, respectively). Fasting blood glucose had higher reproducibility, compared with the 2-h glucose. Youth with discordant OGTTs, compared with those with concordant results, were more insulin resistant (glucose/insulin 2.7+/-1.4 vs. 4.1+/-1.8, P=0.006, whole-body insulin sensitivity index of 1.3+/-0.6 vs. 2.2+/-1.1, P=0.003, and homeostasis model assessment of insulin resistance 10.6+/-8.1 vs. 5.7+/-2.8, P=0.001), had a lower GDI (0.45+/-0.58 vs. 1.02+/-1.0, P=0.03), and had higher low-density lipoprotein cholesterol (117.7+/-36.6 vs. 89.9+/-20.1, P=0.0005) without differences in physical characteristics.RESULTSOf the 10 subjects with impaired glucose tolerance (IGT) during the first OGTT only three (30%) had IGT during the second OGTT. The percent positive agreement between the first and second OGTT was low for both impaired fasting glucose and IGT (22.2 and 27.3%, respectively). Fasting blood glucose had higher reproducibility, compared with the 2-h glucose. Youth with discordant OGTTs, compared with those with concordant results, were more insulin resistant (glucose/insulin 2.7+/-1.4 vs. 4.1+/-1.8, P=0.006, whole-body insulin sensitivity index of 1.3+/-0.6 vs. 2.2+/-1.1, P=0.003, and homeostasis model assessment of insulin resistance 10.6+/-8.1 vs. 5.7+/-2.8, P=0.001), had a lower GDI (0.45+/-0.58 vs. 1.02+/-1.0, P=0.03), and had higher low-density lipoprotein cholesterol (117.7+/-36.6 vs. 89.9+/-20.1, P=0.0005) without differences in physical characteristics.Our results show poor reproducibility of the OGTT in obese youth, in particular for the 2-h plasma glucose. Obese youth who have discordant OGTT results are more insulin resistant with higher risk of developing type 2 diabetes mellitus, as evidenced by a lower GDI. The implications of this remain to be determined in clinical and research settings.CONCLUSIONSOur results show poor reproducibility of the OGTT in obese youth, in particular for the 2-h plasma glucose. Obese youth who have discordant OGTT results are more insulin resistant with higher risk of developing type 2 diabetes mellitus, as evidenced by a lower GDI. The implications of this remain to be determined in clinical and research settings. Objective: We examined the reproducibility of the oral glucose tolerance test (OGTT) in overweight children and evaluated distinguishing characteristics between those with concordant vs. discordant results. Design: Sixty overweight youth (8–17 yr old) completed two OGTTs (interval between tests 1–25 d). Insulin sensitivity was assessed by the surrogate measures of fasting glucose to insulin ratio, whole-body insulin sensitivity index, and homeostasis model assessment of insulin resistance, and insulin secretion by the insulinogenic index with calculation of the glucose disposition index (GDI). Results: Of the 10 subjects with impaired glucose tolerance (IGT) during the first OGTT only three (30%) had IGT during the second OGTT. The percent positive agreement between the first and second OGTT was low for both impaired fasting glucose and IGT (22.2 and 27.3%, respectively). Fasting blood glucose had higher reproducibility, compared with the 2-h glucose. Youth with discordant OGTTs, compared with those with concordant results, were more insulin resistant (glucose/insulin 2.7 ± 1.4 vs. 4.1 ± 1.8, P = 0.006, whole-body insulin sensitivity index of 1.3 ± 0.6 vs. 2.2 ± 1.1, P = 0.003, and homeostasis model assessment of insulin resistance 10.6± 8.1 vs. 5.7 ± 2.8, P = 0.001), had a lower GDI (0.45 ± 0.58 vs. 1.02 ± 1.0, P = 0.03), and had higher low-density lipoprotein cholesterol (117.7 ± 36.6 vs. 89.9 ± 20.1, P = 0.0005) without differences in physical characteristics. Conclusions: Our results show poor reproducibility of the OGTT in obese youth, in particular for the 2-h plasma glucose. Obese youth who have discordant OGTT results are more insulin resistant with higher risk of developing type 2 diabetes mellitus, as evidenced by a lower GDI. The implications of this remain to be determined in clinical and research settings. Poor reproducibility of the oral glucose tolerance test is seen in obese youth, in particular for the 2-hour plasma glucose. We examined the reproducibility of the oral glucose tolerance test (OGTT) in overweight children and evaluated distinguishing characteristics between those with concordant vs. discordant results. Sixty overweight youth (8-17 yr old) completed two OGTTs (interval between tests 1-25 d). Insulin sensitivity was assessed by the surrogate measures of fasting glucose to insulin ratio, whole-body insulin sensitivity index, and homeostasis model assessment of insulin resistance, and insulin secretion by the insulinogenic index with calculation of the glucose disposition index (GDI). Of the 10 subjects with impaired glucose tolerance (IGT) during the first OGTT only three (30%) had IGT during the second OGTT. The percent positive agreement between the first and second OGTT was low for both impaired fasting glucose and IGT (22.2 and 27.3%, respectively). Fasting blood glucose had higher reproducibility, compared with the 2-h glucose. Youth with discordant OGTTs, compared with those with concordant results, were more insulin resistant (glucose/insulin 2.7+/-1.4 vs. 4.1+/-1.8, P=0.006, whole-body insulin sensitivity index of 1.3+/-0.6 vs. 2.2+/-1.1, P=0.003, and homeostasis model assessment of insulin resistance 10.6+/-8.1 vs. 5.7+/-2.8, P=0.001), had a lower GDI (0.45+/-0.58 vs. 1.02+/-1.0, P=0.03), and had higher low-density lipoprotein cholesterol (117.7+/-36.6 vs. 89.9+/-20.1, P=0.0005) without differences in physical characteristics. Our results show poor reproducibility of the OGTT in obese youth, in particular for the 2-h plasma glucose. Obese youth who have discordant OGTT results are more insulin resistant with higher risk of developing type 2 diabetes mellitus, as evidenced by a lower GDI. The implications of this remain to be determined in clinical and research settings. Objective: We examined the reproducibility of the oral glucose tolerance test (OGTT) in overweight children and evaluated distinguishing characteristics between those with concordant vs. discordant results. Design: Sixty overweight youth (8–17 yr old) completed two OGTTs (interval between tests 1–25 d). Insulin sensitivity was assessed by the surrogate measures of fasting glucose to insulin ratio, whole-body insulin sensitivity index, and homeostasis model assessment of insulin resistance, and insulin secretion by the insulinogenic index with calculation of the glucose disposition index (GDI). Results: Of the 10 subjects with impaired glucose tolerance (IGT) during the first OGTT only three (30%) had IGT during the second OGTT. The percent positive agreement between the first and second OGTT was low for both impaired fasting glucose and IGT (22.2 and 27.3%, respectively). Fasting blood glucose had higher reproducibility, compared with the 2-h glucose. Youth with discordant OGTTs, compared with those with concordant results, were more insulin resistant (glucose/insulin 2.7 ± 1.4 vs. 4.1 ± 1.8, P = 0.006, whole-body insulin sensitivity index of 1.3 ± 0.6 vs. 2.2 ± 1.1, P = 0.003, and homeostasis model assessment of insulin resistance 10.6± 8.1 vs. 5.7 ± 2.8, P = 0.001), had a lower GDI (0.45 ± 0.58 vs. 1.02 ± 1.0, P = 0.03), and had higher low-density lipoprotein cholesterol (117.7 ± 36.6 vs. 89.9 ± 20.1, P = 0.0005) without differences in physical characteristics. Conclusions: Our results show poor reproducibility of the OGTT in obese youth, in particular for the 2-h plasma glucose. Obese youth who have discordant OGTT results are more insulin resistant with higher risk of developing type 2 diabetes mellitus, as evidenced by a lower GDI. The implications of this remain to be determined in clinical and research settings. |
| Author | Arslanian, S. Libman, I. M. Barinas-Mitchell, E. Bartucci, A. Robertson, R. |
| AuthorAffiliation | Divisions of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, and Weight Management and Wellness (I.M.L., A.B., S.A.), Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Epidemiology (E.B.-M.), Graduate School of Public Health, and Center for Exercise and Health-Fitness Research (R.R.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260 |
| AuthorAffiliation_xml | – name: Divisions of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, and Weight Management and Wellness (I.M.L., A.B., S.A.), Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Epidemiology (E.B.-M.), Graduate School of Public Health, and Center for Exercise and Health-Fitness Research (R.R.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260 |
| Author_xml | – sequence: 1 givenname: I. M. surname: Libman fullname: Libman, I. M. email: ingrid.libman@chp.edu organization: 1Divisions of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, and Weight Management and Wellness (I.M.L., A.B., S.A.), Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213 – sequence: 2 givenname: E. surname: Barinas-Mitchell fullname: Barinas-Mitchell, E. organization: 2Department of Epidemiology (E.B.-M.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260 – sequence: 3 givenname: A. surname: Bartucci fullname: Bartucci, A. organization: 1Divisions of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, and Weight Management and Wellness (I.M.L., A.B., S.A.), Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213 – sequence: 4 givenname: R. surname: Robertson fullname: Robertson, R. organization: 3Graduate School of Public Health, and Center for Exercise and Health-Fitness Research (R.R.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260 – sequence: 5 givenname: S. surname: Arslanian fullname: Arslanian, S. organization: 1Divisions of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, and Weight Management and Wellness (I.M.L., A.B., S.A.), Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213 |
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| ContentType | Journal Article |
| Copyright | Copyright © 2008 by The Endocrine Society 2008 Copyright © 2008 by The Endocrine Society 2008 INIST-CNRS Copyright © 2008 by The Endocrine Society 2008 |
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| Issue | 11 |
| Keywords | Human Obesity Nutrition Body weight Nutrition disorder Oral administration Metabolic diseases Corporal biometry Glucose tolerance test Overweight Reproducibility Child Endocrinology Nutritional status |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Address all correspondence and requests for reprints to: Ingrid M. Libman, M.D., Ph.D., Children’s Hospital of Pittsburgh, 3705 Fifth Avenue, 4th A De Soto Wing, Pittsburgh, Pennsylvania 15213. E-mail: ingrid.libman@chp.edu. |
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| PublicationTitle | The journal of clinical endocrinology and metabolism |
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| Publisher | Oxford University Press Copyright by The Endocrine Society Endocrine Society The Endocrine Society |
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| References | Conwell ( key 2019041114084461900_R14) 2004; 40 Sinha ( key 2019041114084461900_R4) 2002; 346 Rothwell ( key 2019041114084461900_R21) 2000; 415 Matsuda ( key 2019041114084461900_R15) 1999; 22 Szklo ( key 2019041114084461900_R23) 2007 Ko ( key 2019041114084461900_R10) 1998; 35 Gungor ( key 2019041114084461900_R1) 2005; 52 American Diabetes Association ( key 2019041114084461900_R2) 2000; 23 Invitti ( key 2019041114084461900_R25) 2003; 26 Mooy ( key 2019041114084461900_R9) 1996; 39 The International Diabetes Federation Consensus Workshop ( key 2019041114084461900_R5) 2004; 27 Lyssenko ( key 2019041114084461900_R17) 2005; 54 Lachin ( key 2019041114084461900_R24) 2004; 1 Barrett-Connor ( key 2019041114084461900_R6) 2002; 23 Ehtisham ( key 2019041114084461900_R26) 2004; 27 Yeckel ( key 2019041114084461900_R16) 2004; 89 Qiao ( key 2019041114084461900_R7) 2002; 23 American Diabetes Association ( key 2019041114084461900_R13) 2007; 30 Gungor ( key 2019041114084461900_R18) 2004; 144 Bacha ( key 2019041114084461900_R19) 2008; 152 Brohall ( key 2019041114084461900_R12) 2006; 29 Rocchini ( key 2019041114084461900_R3) 2002; 346 Tuomilehto ( key 2019041114084461900_R8) 2002; 25 Davidson ( key 2019041114084461900_R11) 2002; 25 Bland ( key 2019041114084461900_R20) 1986; 1 Shrout ( key 2019041114084461900_R22) 1979; 2 18987283 - J Clin Endocrinol Metab. 2008 Nov;93(11):4228-30 |
| References_xml | – volume: 26 start-page: 118 year: 2003 ident: key 2019041114084461900_R25 article-title: Prevalence and concomitants of glucose intolerance in European obese children and adolescents. publication-title: Diabetes Care doi: 10.2337/diacare.26.1.118 – volume: 35 start-page: 62 year: 1998 ident: key 2019041114084461900_R10 article-title: The reproducibility and usefulness of the oral glucose tolerance test in screening for diabetes and other cardiovascular risk factors. publication-title: Ann Clin Biochem doi: 10.1177/000456329803500107 – volume: 29 start-page: 363 year: 2006 ident: key 2019041114084461900_R12 article-title: Prevalence of diabetes and impaired glucose tolerance in 64-year old Swedish women. Experiences using repeated oral glucose tolerance tests. publication-title: Diabetes Care doi: 10.2337/diacare.29.02.06.dc05-1229 – volume: 25 start-page: 1883 year: 2002 ident: key 2019041114084461900_R11 article-title: Counterpoint: the oral glucose tolerance test is superfluous. publication-title: Diabetes Care doi: 10.2337/diacare.25.10.1883 – volume: 27 start-page: 280 year: 2004 ident: key 2019041114084461900_R26 article-title: Development of an assessment tool for screening children for glucose intolerance by oral glucose tolerance test. publication-title: Diabetes Care doi: 10.2337/diacare.27.1.280 – volume: 152 start-page: 618 year: 2008 ident: key 2019041114084461900_R19 article-title: Measures of β-cell function during oral glucose tolerance test and liquid mixed meal in youth: how well do they correlate with the gold standard of the hyperglycemic clamp? publication-title: J Pediatr doi: 10.1016/j.jpeds.2007.11.044 – volume: 22 start-page: 1462 year: 1999 ident: key 2019041114084461900_R15 article-title: Insulin sensitivity indices obtained from oral glucose tolerance testing. Comparison with the euglycemic insulin clamp. publication-title: Diabetes Care doi: 10.2337/diacare.22.9.1462 – volume: 1 start-page: 553 year: 2004 ident: key 2019041114084461900_R24 article-title: The role of measurement reliability in clinical trials. publication-title: Clin Trials doi: 10.1191/1740774504cn057oa – year: 2007 ident: key 2019041114084461900_R23 – volume: 2 start-page: 420 year: 1979 ident: key 2019041114084461900_R22 article-title: Intraclass correlations uses in assessing rater reliability. publication-title: Psychol Bull doi: 10.1037/0033-2909.86.2.420 – volume: 39 start-page: 298 year: 1996 ident: key 2019041114084461900_R9 article-title: Intra-individual variation of glucose, specific insulin and proinsulin concentrations measured by two oral glucose tolerance tests in a general Caucasian population: the Hoorn Study. publication-title: Diabetologia doi: 10.1007/BF00418345 – volume: 30 start-page: s42 year: 2007 ident: key 2019041114084461900_R13 article-title: Diagnosis and classification of diabetes mellitus publication-title: Diabetes Care doi: 10.2337/dc07-S042 – volume: 346 start-page: 854 year: 2002 ident: key 2019041114084461900_R3 article-title: Childhood obesity and a diabetes epidemic. publication-title: N Engl J Med doi: 10.1056/NEJM200203143461112 – volume: 1 start-page: 307 year: 1986 ident: key 2019041114084461900_R20 article-title: Statistical methods for assessing agreement between two methods of clinical measurement. publication-title: Lancet doi: 10.1016/S0140-6736(86)90837-8 – volume: 346 start-page: 802 year: 2002 ident: key 2019041114084461900_R4 article-title: Prevalence of impaired glucose tolerance among children adn adolescents with marked obesity. publication-title: N Engl J Med doi: 10.1056/NEJMoa012578 – volume: 23 start-page: 381 year: 2000 ident: key 2019041114084461900_R2 article-title: Type 2 diabetes in children and adolescents. publication-title: Diabetes Care doi: 10.2337/diacare.23.3.381 – volume: 52 start-page: 1579 year: 2005 ident: key 2019041114084461900_R1 article-title: Type 2 diabetes mellitus in youth: the complete picture to date. publication-title: Pediatr Clin North Am doi: 10.1016/j.pcl.2005.07.009 – volume: 415 start-page: 825 year: 2000 ident: key 2019041114084461900_R21 article-title: Analysis of agreement between measurements of continuous variables: general principles and lessons from studies of imaging of carotid stenosis. publication-title: J Neurol doi: 10.1007/s004150070068 – volume: 25 start-page: 1880 year: 2002 ident: key 2019041114084461900_R8 article-title: Point: a glucose tolerance test is important for clinical practice. publication-title: Diabetes Care doi: 10.2337/diacare.25.10.1880 – volume: 40 start-page: 620 year: 2004 ident: key 2019041114084461900_R14 article-title: Oral glucose tolerance test in children and adolescents: positives and pitfalls. publication-title: J Paediatr Child Health doi: 10.1111/j.1440-1754.2004.00487.x – volume: 144 start-page: 47 year: 2004 ident: key 2019041114084461900_R18 article-title: Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. publication-title: J Pediatr doi: 10.1016/j.jpeds.2003.09.045 – volume: 54 start-page: 166 year: 2005 ident: key 2019041114084461900_R17 article-title: Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. publication-title: Diabetes doi: 10.2337/diabetes.54.1.166 – volume: 27 start-page: 1794 year: 2004 ident: key 2019041114084461900_R5 article-title: Type 2 diabetes in the young: the evolving epidemic. publication-title: Diabetes Care – volume: 89 start-page: 1096 year: 2004 ident: key 2019041114084461900_R16 article-title: Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents. publication-title: J Clin Endocrinal Metab doi: 10.1210/jc.2003-031503 – volume: 23 start-page: 1267 year: 2002 ident: key 2019041114084461900_R7 article-title: Two-hour glucose is a better risk predictor for incident coronary heart disease and cardiovascular mortality than fasting glucose. publication-title: Eur Heart J doi: 10.1053/euhj.2001.3113 – volume: 23 start-page: 1229 year: 2002 ident: key 2019041114084461900_R6 article-title: The oral glucose tolerance test—revisited. publication-title: Eur Heart J doi: 10.1053/euhj.2002.3243 – reference: 18987283 - J Clin Endocrinol Metab. 2008 Nov;93(11):4228-30 |
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| SubjectTerms | Administration, Oral Adolescent Biological and medical sciences Blood Glucose - metabolism Body Mass Index Body weight C-Peptide - blood Child Cholesterol Diabetes mellitus (non-insulin dependent) Endocrinopathies Fasting Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Glucose Glucose - administration & dosage Glucose Intolerance - blood Glucose Intolerance - diagnosis Glucose tolerance Glucose Tolerance Test - standards Homeostasis Humans Insulin - blood Insulin - metabolism Insulin Resistance Insulin Secretion Laboratory testing Male Medical sciences Obesity - blood Original Overweight Overweight - blood Physical characteristics Puberty Reproducibility Reproducibility of Results Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| Title | Reproducibility of the Oral Glucose Tolerance Test in Overweight Children |
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