mdm2和p53基因在急性白血病细胞中的表达及意义

R733.7; 目的:探讨人急性髓细胞性白血病(acutemyeloid leukemia,AML)细胞mdm2及p53基因蛋白表达水平、相互关系及与临床预后的关系.方法:用免疫组化方法测定mdm2及p53蛋白表达,HPIAS 1000高清晰度病理图像细胞测定系统分析结果.结果:75%的AML患者表达不同程度的mdm2蛋白,且在各种分型中均有mdm2蛋白过度表达者;18.75%的AML患者表达p53蛋白;在AML患者中mdm2蛋白阳性同时p53蛋白阴性者占65.63%;mdm2表达阳性者其完全缓解率(29.17%)较mdm2阴性者(83.3%)明显减低(P<0.01),mdm2与p53蛋...

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Published in癌症 Vol. 19; no. 8; pp. 786 - 788
Main Authors 樊娟, 徐功立, 徐键, 王春霞, 闵捷, 李英
Format Journal Article
LanguageChinese
Published 山东省立医院血液科,山东,济南,250021%山东省立医院中心实验室,山东,济南,250021 2000
Subjects
预后
急性
白血病
mdm2
p53
Online AccessGet full text
ISSN1000-467X
DOI10.3321/j.issn:1000-467X.2000.08.015

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Abstract R733.7; 目的:探讨人急性髓细胞性白血病(acutemyeloid leukemia,AML)细胞mdm2及p53基因蛋白表达水平、相互关系及与临床预后的关系.方法:用免疫组化方法测定mdm2及p53蛋白表达,HPIAS 1000高清晰度病理图像细胞测定系统分析结果.结果:75%的AML患者表达不同程度的mdm2蛋白,且在各种分型中均有mdm2蛋白过度表达者;18.75%的AML患者表达p53蛋白;在AML患者中mdm2蛋白阳性同时p53蛋白阴性者占65.63%;mdm2表达阳性者其完全缓解率(29.17%)较mdm2阴性者(83.3%)明显减低(P<0.01),mdm2与p53蛋白均阳性者缓解率最低,而两种蛋白均阴性者均获完全缓解.结论:在AML患者中有较高水平的mdm2蛋白表达,以mdm2阳性(+)、p53阴性(-)为其主要表达方式,且mdm2及p53蛋白表达与临床疗效有密切的关系.
AbstractList R733.7; 目的:探讨人急性髓细胞性白血病(acutemyeloid leukemia,AML)细胞mdm2及p53基因蛋白表达水平、相互关系及与临床预后的关系.方法:用免疫组化方法测定mdm2及p53蛋白表达,HPIAS 1000高清晰度病理图像细胞测定系统分析结果.结果:75%的AML患者表达不同程度的mdm2蛋白,且在各种分型中均有mdm2蛋白过度表达者;18.75%的AML患者表达p53蛋白;在AML患者中mdm2蛋白阳性同时p53蛋白阴性者占65.63%;mdm2表达阳性者其完全缓解率(29.17%)较mdm2阴性者(83.3%)明显减低(P<0.01),mdm2与p53蛋白均阳性者缓解率最低,而两种蛋白均阴性者均获完全缓解.结论:在AML患者中有较高水平的mdm2蛋白表达,以mdm2阳性(+)、p53阴性(-)为其主要表达方式,且mdm2及p53蛋白表达与临床疗效有密切的关系.
Author 闵捷
樊娟
徐键
王春霞
徐功立
李英
AuthorAffiliation 山东省立医院血液科,山东,济南,250021%山东省立医院中心实验室,山东,济南,250021
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急性
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mdm2
p53
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Snippet R733.7; 目的:探讨人急性髓细胞性白血病(acutemyeloid leukemia,AML)细胞mdm2及p53基因蛋白表达水平、相互关系及与临床预后的关系.方法:用免疫组化方法测定mdm2及p53蛋白表达,HPIAS...
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Title mdm2和p53基因在急性白血病细胞中的表达及意义
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