Glcci1 Deficiency Leads to Proteinuria

• Published in: Journal of the American Society of Nephrology Vol. 22; no. 11; pp. 2037 - 2046
• Main Authors: NISHIBORI, Yukino, KATAYAMA, Kan, NORLIN, Jenny, UHLEN, Mathias, PATRAKKA, Jaakko, BETSHOLTZ, Christer, TRYGGVASON, Karl, PARIKKA, Mataleena, ODDSSON, Asmundur, NUKUI, Masatoshi, HULTENBY, Kjell, WERNERSON, Annika, BING HE, EBARASI, Lwaki, RASCHPERGER, Elisabeth
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society of Nephrology 01.11.2011
• Subjects: Animals; Basic Research; Biological and medical sciences; Cytoplasm - metabolism; Dexamethasone - pharmacology; Disease Models, Animal; Gene Expression Regulation, Developmental - drug effects; Gene Expression Regulation, Developmental - physiology; Glucocorticoids - pharmacology; Kidney Glomerulus - abnormalities; Kidney Glomerulus - physiopathology; Male; Medical sciences; Medicin och hälsovetenskap; Mice; Mice, Inbred ICR; Nephrology. Urinary tract diseases; Oligonucleotides, Antisense - pharmacology; Podocytes - physiology; Pronephros - abnormalities; Pronephros - physiopathology; Proteinuria - metabolism; Proteinuria - pathology; Proteinuria - physiopathology; Rabbits; Receptors, Glucocorticoid - deficiency; Receptors, Glucocorticoid - genetics; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Zebrafish; Nephrology; Urinary system disease; Deficiency; Lead; Urology; Heavy metal; Proteinuria; LOCALIZES; ZEBRAFISH; NEPHRIN; GLOMERULAR TRANSCRIPTOME; GENE-EXPRESSION; PODOCIN; KIDNEY; IDENTIFICATION; CELL

Unbiased transcriptome profiling and functional genomics approaches identified glucocorticoid-induced transcript 1 (GLCCI1) as being a transcript highly specific for the glomerulus, but its role in glomerular development and disease is unknown. Here, we report that mouse glomeruli express far greate...