Role of HYBID (Hyaluronan Binding Protein Involved in Hyaluronan Depolymerization), Alias KIAA1199/CEMIP, in Hyaluronan Degradation in Normal and Photoaged Skin

• Published in: International journal of molecular sciences Vol. 20; no. 22; p. 5804
• Main Authors: Yoshida, Hiroyuki, Okada, Yasunori
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.11.2019; MDPI
• Subjects: Amino acids; Animals; Biodegradation; CD44 antigen; Cell adhesion & migration; Collagen; Deafness; Depolymerization; DNA microarrays; extracellular matrix; Fibroblasts; Gene expression; Genes; Heparan sulfate; Homeostasis; Humans; hyaluronan; hyaluronan degradation; hyaluronan synthase; Hyaluronic acid; Hyaluronic Acid - metabolism; Hyaluronoglucosaminidase - metabolism; hybid; kiaa1199/cemip; Neuroendocrine system; photoaging; Polymerization; Proteins; Review; sagging; siRNA; Skin; Skin - metabolism; Skin - pathology; Skin Aging - pathology; wrinkle; fibroblasts; KIAA1199/CEMIP; hyaluronan; skin; hyaluronan degradation; hyaluronan synthase; sagging; HYBID; wrinkle; extracellular matrix; photoaging

Photoaged skin is characterized clinically by apparent manifestations such as wrinkles and sagging, and histologically by an accumulation of abnormal elastin and a severe loss of collagen fibers in the dermis. Quantitative and qualitative alterations in elastin and collagens are considered to be res...