Kinetics and Dose Dependency of Intranasal Oxytocin Effects on Amygdala Reactivity

• Published in: Biological psychiatry (1969) Vol. 82; no. 12; pp. 885 - 894
• Main Authors: Spengler, Franny B., Schultz, Johannes, Scheele, Dirk, Essel, Maximiliane, Maier, Wolfgang, Heinrichs, Markus, Hurlemann, René
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.12.2017
• Subjects: Administration, Intranasal; Adult; Amygdala; Amygdala - diagnostic imaging; Amygdala - drug effects; Amygdala - physiology; Autistic-like traits; Brain Mapping; Cross-Over Studies; Dose; Dose-Response Relationship, Drug; Double-Blind Method; Emotion recognition; Emotions - drug effects; Emotions - physiology; Facial Recognition - drug effects; Facial Recognition - physiology; fMRI; Humans; Kinetics; Magnetic Resonance Imaging; Male; Oxytocin; Oxytocin - administration & dosage; Oxytocin - pharmacokinetics; Psychiatric/Mental Health; Psychotropic Drugs - administration & dosage; Psychotropic Drugs - pharmacokinetics; Time Factors; Young Adult; Emotion recognition; fMRI; Autistic-like traits; Amygdala; Oxytocin; Dose

Current neuroimaging perspectives on a variety of mental disorders emphasize dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the regulation of social cognition and behavior, accumulates in cerebrospinal fluid after intranasal administration in macaques and humans and...