Energy-Dependent Endocytosis is Involved in the Absorption of Indomethacin Nanoparticles in the Small Intestine

• Published in: International journal of molecular sciences Vol. 20; no. 3; p. 476
• Main Authors: Ishii, Miyu, Fukuoka, Yuya, Deguchi, Saori, Otake, Hiroko, Tanino, Tadatoshi, Nagai, Noriaki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.01.2019; MDPI
• Subjects: Adenocarcinoma; Animals; Bacteria; Caco-2 Cells; drug delivery system; Drug delivery systems; Drug Delivery Systems - methods; Drug dosages; Endocytosis; Endocytosis - physiology; Energy; Humans; Indomethacin; Indomethacin - metabolism; Inflammation; Injury prevention; Intestine; Intestine, Small - metabolism; Male; Monolayers; Mucosa; nanoparticle; Nanoparticles; Nanoparticles - chemistry; Nonsteroidal anti-inflammatory drugs; oral route; Particle size; Quantum dots; Rats; Rats, Wistar; Rodents; Small intestine; Stability analysis; Ulcers; endocytosis; nanoparticle; drug delivery system; oral route; indomethacin

We previously reported that oral formulations containing indomethacin nanoparticles (IND-NPs) showed high bioavailability, and, consequently, improved therapeutic effects and reduced injury to the small intestine. However, the pathway for the transintestinal penetration of nanoparticles remained unc...