Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells - Kronenberg, Deborah; Knight, Robin R.; Estorninho, Megan; Ellis, Richard J.; Kester, Michel G.; de Ru, Arnoud; Eichmann, Martin; Huang, Guo C.; Powrie, Jake; Dayan, Colin M.; Skowera, Ania; van Veelen, Peter A.; et al. (Diabetes (New York, N.Y.), 2012)
Keywords: Adult; Analysis; Autoantibodies - blood; Autoantibodies - immunology; Biological and medical sciences; CD8-Positive T-Lymphocytes - immunology; Cell Death - immunology; Cell Line; Diabetes Mellitus, Type 1 - immunology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epitopes, T-Lymphocyte - immunology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glutamate Decarboxylase - immunology; HLA class II antigens; HLA-A24 Antigen - immunology; Humans; Immunology and Transplantation; Insulin - blood; Insulin - immunology; Insulin-Secreting Cells - immunology; Male; Medical sciences; Middle Aged; Physiological aspects; Protein Precursors - blood; Protein Precursors - immunology; Protein Sorting Signals; T cells; Type 1 diabetes; Young Adult; Endocrinopathy; Immunopathology; HLA-System; Sensitivity; Peptides; Type 1 diabetes; Langerhans islet; T-Lymphocyte; Autoimmune disease; β Cell; Endocrine pancreas