Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids

• Published in: Cancer letters Vol. 518; pp. 59 - 71
• Main Authors: Koh, Vivien, Chakrabarti, Jayati, Torvund, Meaghan, Steele, Nina, Hawkins, Jennifer A., Ito, Yoshiaki, Wang, Jiang, Helmrath, Michael A., Merchant, Juanita L., Ahmed, Syed A., Shabbir, Asim, Yan So, Jimmy Bok, Yong, Wei Peng, Zavros, Yana
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.10.2021; Elsevier Limited
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Apoptosis; Autografts; B7-H1 Antigen - genetics; Cancer therapies; CD8 antigen; CD8-Positive T-Lymphocytes - metabolism; Cell death; Cells, Cultured; Chemotherapy; Cytokines; Cytotoxic T lymphocytes; Cytotoxicity; Dendritic cells; Epithelium; Fatalities; Gastric cancer; Gene regulation; Growth factors; Hedgehog protein; Hedgehog Proteins - genetics; Helicobacter pylori - pathogenicity; Human subjects; Humans; Immunomodulation; Immunosurveillance; Immunotherapy; Immunotherapy - methods; Ligands; Lymphocytes; Lymphocytes T; Metastases; Monoclonal antibodies; Myeloid derived suppressor cells; Organoids; Organoids - metabolism; PD-1 protein; PD-L1 protein; Rapamycin; Regulation; Signal transduction; Signal Transduction - genetics; Sonic hedgehog; Stomach Neoplasms - genetics; Stomach Neoplasms - microbiology; T-Lymphocytes, Cytotoxic - metabolism; Targeted cancer therapy; TOR protein; TOR Serine-Threonine Kinases - genetics; Transcription; Transcription, Genetic - genetics; Transplantation; Tumor microenvironment; Tumor Microenvironment - genetics; Tumor necrosis factor-TNF; Tumors; Zinc Finger Protein GLI1 - genetics; Sonic hedgehog; Tumor microenvironment; Myeloid derived suppressor cells; Cytotoxic T lymphocytes

Tumors evade immune surveillance by expressing Programmed Death-Ligand 1 (PD-L1), subsequently inhibiting CD8+ cytotoxic T lymphocyte function. Response of gastric cancer to immunotherapy is relatively low. Our laboratory has reported that Helicobacter pylori-induced PD-L1 expression within the gast...