Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids - Koh, Vivien; Chakrabarti, Jayati; Torvund, Meaghan; Steele, Nina; Hawkins, Jennifer A.; Ito, Yoshiaki; Wang, Jiang; Helmrath, Michael A.; Merchant, Juanita L.; Ahmed, Syed A.; Shabbir, Asim; Yan So, Jimmy Bok; et al. (Cancer letters, 2021)
Keywords: 1-Phosphatidylinositol 3-kinase; AKT protein; Apoptosis; Autografts; B7-H1 Antigen - genetics; Cancer therapies; CD8 antigen; CD8-Positive T-Lymphocytes - metabolism; Cell death; Cells, Cultured; Chemotherapy; Cytokines; Cytotoxic T lymphocytes; Cytotoxicity; Dendritic cells; Epithelium; Fatalities; Gastric cancer; Gene regulation; Growth factors; Hedgehog protein; Hedgehog Proteins - genetics; Helicobacter pylori - pathogenicity; Human subjects; Humans; Immunomodulation; Immunosurveillance; Immunotherapy; Immunotherapy - methods; Ligands; Lymphocytes; Lymphocytes T; Metastases; Monoclonal antibodies; Myeloid derived suppressor cells; Organoids; Organoids - metabolism; PD-1 protein; PD-L1 protein; Rapamycin; Regulation; Signal transduction; Signal Transduction - genetics; Sonic hedgehog; Stomach Neoplasms - genetics; Stomach Neoplasms - microbiology; T-Lymphocytes, Cytotoxic - metabolism; Targeted cancer therapy; TOR protein; TOR Serine-Threonine Kinases - genetics; Transcription; Transcription, Genetic - genetics; Transplantation; Tumor microenvironment; Tumor Microenvironment - genetics; Tumor necrosis factor-TNF; Tumors; Zinc Finger Protein GLI1 - genetics; Sonic hedgehog; Tumor microenvironment; Myeloid derived suppressor cells; Cytotoxic T lymphocytes