Micronization of taxifolin by supercritical antisolvent process and evaluation of radical scavenging activity

• Published in: International journal of molecular sciences Vol. 13; no. 7; pp. 8869 - 8881
• Main Authors: Zu, Shuchong, Yang, Lei, Huang, Jinming, Ma, Chunhui, Wang, Wenjie, Zhao, Chunjian, Zu, Yuangang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.07.2012; Molecular Diversity Preservation International (MDPI)
• Subjects: Bioavailability; dissolution rate; Free Radical Scavengers - chemistry; Hot Temperature; Larix gmelinii; micronization; Morphology; Particle Size; Pharmaceuticals; Quercetin - analogs & derivatives; Quercetin - chemistry; radical scavenging activity; Scanning electron microscopy; Solvents; supercritical antisolvent; taxifolin; Larix gmelinii; dissolution rate; radical scavenging activity; supercritical antisolvent; taxifolin; micronization

The aim of this study was to prepare micronized taxifolin powder using the supercritical antisolvent precipitation process to improve the dissolution rate of taxifolin. Ethanol was used as solvent and carbon dioxide was used as an antisolvent. The effects of process parameters, such as temperature (...