Concurrent Presence of Obstructive Sleep Apnea and Elevated Homocysteine Levels Exacerbate the Development of Hypertension: A KoGES Six-year Follow-up Study
Accumulating evidence has revealed that obstructive sleep apnea (OSA) and high homocysteine (Hcy) levels play important roles in the increased risk of hypertension and cardiovascular disease. We investigated whether the presence of elevated Hcy levels among individuals with OSA increase the risk of...
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Published in | Scientific reports Vol. 8; no. 1; pp. 2665 - 8 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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08.02.2018
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Abstract | Accumulating evidence has revealed that obstructive sleep apnea (OSA) and high homocysteine (Hcy) levels play important roles in the increased risk of hypertension and cardiovascular disease. We investigated whether the presence of elevated Hcy levels among individuals with OSA increase the risk of hypertension in a cohort study. A total of 1825 participants were selected from the cohort study. A high homocysteine level (Hcy) was defined as those in the 75th percentile of Hcy levels of the study cohort. The prevalence of hypertension was higher among subjects with OSA and high Hcy levels than among the other groups stratified by the presence of OSA and high Hcy levels. The incidence of hypertension at 6-year follow-up was: Hcy[-]/OSA[-] vs. Hcy[+]/OSA[-] vs. Hcy[-]/OSA[+] vs. Hcy[+]/OSA[+], 14.2% vs. 19.8% vs. 24.2% vs. 36.1%. After adjusting for confounding factors, subjects with OSA and high Hcy levels had a 1.86-fold risk of developing hypertension compared to those without OSA and high Hcy levels. Moderate to severe OSA group with the highest tertile of Hcy levels had a 2.31-fold increased risk of developing hypertension. Interaction between Hcy and OSA on development of hypertension was significant, suggesting that these conditions may constitute an important determinant. |
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AbstractList | Accumulating evidence has revealed that obstructive sleep apnea (OSA) and high homocysteine (Hcy) levels play important roles in the increased risk of hypertension and cardiovascular disease. We investigated whether the presence of elevated Hcy levels among individuals with OSA increase the risk of hypertension in a cohort study. A total of 1825 participants were selected from the cohort study. A high homocysteine level (Hcy) was defined as those in the 75th percentile of Hcy levels of the study cohort. The prevalence of hypertension was higher among subjects with OSA and high Hcy levels than among the other groups stratified by the presence of OSA and high Hcy levels. The incidence of hypertension at 6-year follow-up was: Hcy[−]/OSA[−] vs. Hcy[+]/OSA[−] vs. Hcy[−]/OSA[+] vs. Hcy[+]/OSA[+], 14.2% vs. 19.8% vs. 24.2% vs. 36.1%. After adjusting for confounding factors, subjects with OSA and high Hcy levels had a 1.86-fold risk of developing hypertension compared to those without OSA and high Hcy levels. Moderate to severe OSA group with the highest tertile of Hcy levels had a 2.31-fold increased risk of developing hypertension. Interaction between Hcy and OSA on development of hypertension was significant, suggesting that these conditions may constitute an important determinant. Accumulating evidence has revealed that obstructive sleep apnea (OSA) and high homocysteine (Hcy) levels play important roles in the increased risk of hypertension and cardiovascular disease. We investigated whether the presence of elevated Hcy levels among individuals with OSA increase the risk of hypertension in a cohort study. A total of 1825 participants were selected from the cohort study. A high homocysteine level (Hcy) was defined as those in the 75th percentile of Hcy levels of the study cohort. The prevalence of hypertension was higher among subjects with OSA and high Hcy levels than among the other groups stratified by the presence of OSA and high Hcy levels. The incidence of hypertension at 6-year follow-up was: Hcy[-]/OSA[-] vs. Hcy[+]/OSA[-] vs. Hcy[-]/OSA[+] vs. Hcy[+]/OSA[+], 14.2% vs. 19.8% vs. 24.2% vs. 36.1%. After adjusting for confounding factors, subjects with OSA and high Hcy levels had a 1.86-fold risk of developing hypertension compared to those without OSA and high Hcy levels. Moderate to severe OSA group with the highest tertile of Hcy levels had a 2.31-fold increased risk of developing hypertension. Interaction between Hcy and OSA on development of hypertension was significant, suggesting that these conditions may constitute an important determinant. Abstract Accumulating evidence has revealed that obstructive sleep apnea (OSA) and high homocysteine (Hcy) levels play important roles in the increased risk of hypertension and cardiovascular disease. We investigated whether the presence of elevated Hcy levels among individuals with OSA increase the risk of hypertension in a cohort study. A total of 1825 participants were selected from the cohort study. A high homocysteine level (Hcy) was defined as those in the 75th percentile of Hcy levels of the study cohort. The prevalence of hypertension was higher among subjects with OSA and high Hcy levels than among the other groups stratified by the presence of OSA and high Hcy levels. The incidence of hypertension at 6-year follow-up was: Hcy[−]/OSA[−] vs. Hcy[+]/OSA[−] vs. Hcy[−]/OSA[+] vs. Hcy[+]/OSA[+], 14.2% vs. 19.8% vs. 24.2% vs. 36.1%. After adjusting for confounding factors, subjects with OSA and high Hcy levels had a 1.86-fold risk of developing hypertension compared to those without OSA and high Hcy levels. Moderate to severe OSA group with the highest tertile of Hcy levels had a 2.31-fold increased risk of developing hypertension. Interaction between Hcy and OSA on development of hypertension was significant, suggesting that these conditions may constitute an important determinant. |
ArticleNumber | 2665 |
Author | Lee, Seung Ku Yoon, Dae Wui Kim, Jinkwan Shin, Chol |
Author_xml | – sequence: 1 givenname: Jinkwan surname: Kim fullname: Kim, Jinkwan organization: Department of Biomedical Laboratory Science, College of Health Science, Jungwon University, Geo-San, Republic of Korea – sequence: 2 givenname: Seung Ku surname: Lee fullname: Lee, Seung Ku organization: Institute of Human Genomic Study, Korea University Ansan Hospital, Korea University, Ansan, Republic of Korea – sequence: 3 givenname: Dae Wui surname: Yoon fullname: Yoon, Dae Wui organization: Institute of Human Genomic Study, Korea University Ansan Hospital, Korea University, Ansan, Republic of Korea – sequence: 4 givenname: Chol surname: Shin fullname: Shin, Chol email: chol-shin@korea.ac.kr, chol-shin@korea.ac.kr organization: Institute of Human Genomic Study, Korea University Ansan Hospital, Korea University, Ansan, Republic of Korea. chol-shin@korea.ac.kr |
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CitedBy_id | crossref_primary_10_3390_diseases9040088 crossref_primary_10_23736_S0031_0808_21_04273_7 crossref_primary_10_2174_1567202620666230627145908 crossref_primary_10_1016_j_sleep_2024_05_050 crossref_primary_10_1038_s41440_019_0260_4 crossref_primary_10_14639_0392_100X_N0409 crossref_primary_10_1536_ihj_23_384 crossref_primary_10_1007_s00405_024_08614_z crossref_primary_10_3389_fcvm_2023_1030257 crossref_primary_10_1007_s12603_022_1840_6 crossref_primary_10_1016_j_sleep_2024_07_003 crossref_primary_10_1186_s12931_023_02627_8 crossref_primary_10_3389_fnins_2021_762552 crossref_primary_10_1002_jcla_22712 |
Cites_doi | 10.1016/j.pcad.2009.01.002 10.1164/rccm.201101-0130OC 10.1001/jama.288.16.2015 10.1186/1475-2891-14-6 10.1016/j.mam.2016.11.003 10.1371/journal.pone.0163017 10.1378/chest.120.3.900 10.3978/j.issn.2072-1439.2015.06.11 10.1378/chest.15-0136 10.1371/journal.pone.0095794 10.1016/j.rmed.2016.01.015 10.1007/s11906-014-0482-4 10.1016/j.ejmg.2014.10.004 10.1001/jama.2012.3418 10.1016/j.ehj.2004.05.018 10.1164/rccm.200407-906OC 10.1016/S0002-9343(02)01021-5 10.1056/NEJM200005113421901 10.1007/s11325-014-0940-x 10.1183/09031936.00086608 10.1038/hr.2016.11 10.1164/rccm.200712-1809OC 10.1080/07315724.2013.839909 10.1080/1354750X.2016.1201540 10.1093/sleep/15.2.174 10.1016/j.rmed.2005.05.025 10.1016/j.resp.2011.04.024 10.1016/j.jocn.2011.01.037 10.1016/j.resp.2011.12.009 10.1159/000210429 10.1164/rccm.200404-519OC |
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Snippet | Accumulating evidence has revealed that obstructive sleep apnea (OSA) and high homocysteine (Hcy) levels play important roles in the increased risk of... Abstract Accumulating evidence has revealed that obstructive sleep apnea (OSA) and high homocysteine (Hcy) levels play important roles in the increased risk of... |
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StartPage | 2665 |
SubjectTerms | Adult Apnea Blood Pressure Cardiovascular diseases Cardiovascular Diseases - etiology Cohort Studies Female Follow-Up Studies Health risk assessment Homocysteine Homocysteine - analysis Homocysteine - metabolism Humans Hypertension Hypertension - complications Hypertension - etiology Hypertension - metabolism Incidence Longitudinal Studies Male Middle Aged Polysomnography Prevalence Prospective Studies Risk Factors Sleep Sleep apnea Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - physiopathology Sleep disorders |
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Title | Concurrent Presence of Obstructive Sleep Apnea and Elevated Homocysteine Levels Exacerbate the Development of Hypertension: A KoGES Six-year Follow-up Study |
URI | https://www.ncbi.nlm.nih.gov/pubmed/29422547 https://www.proquest.com/docview/1999658496/abstract/ https://search.proquest.com/docview/2001070178 https://pubmed.ncbi.nlm.nih.gov/PMC5805705 |
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