Modeling Trophoblast Cell-Guided Uterine Spiral Artery Transformation in the Rat

• Published in: International journal of molecular sciences Vol. 23; no. 6; p. 2947
• Main Authors: Shukla, Vinay, Soares, Michael J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.03.2022; MDPI
• Subjects: Animals; Arteries; Blood vessels; Female; Fetuses; Genome editing; Genomes; In vivo methods and tests; invasive trophoblast cells; Nutrients; Phenotyping; Placenta; Placenta - blood supply; Placentation - physiology; Pregnancy; rat; Rats; Review; Smooth muscle; Trophoblasts - physiology; Uterine Artery; uterine spiral artery remodeling; Uterus; Uterus - blood supply; Veins & arteries; placenta; invasive trophoblast cells; rat; uterine spiral artery remodeling

The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-guided uterine spiral artery remodeling, which resembles human placentation. Uterine spiral arteries are extensively remodeled to deliver sufficient supply of maternal blood and nutrients to t...