Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins

• Published in: International journal of molecular sciences Vol. 19; no. 8; p. 2161
• Main Authors: Trezise, Stephanie, Karnowski, Alexander, Fedele, Pasquale L, Mithraprabhu, Sridurga, Liao, Yang, D'Costa, Kathy, Kueh, Andrew J, Hardy, Matthew P, Owczarek, Catherine M, Herold, Marco J, Spencer, Andrew, Shi, Wei, Willis, Simon N, Nutt, Stephen L, Corcoran, Lynn M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.07.2018; MDPI
• Subjects: Animals; antibody; Antibody-Producing Cells - immunology; Autoimmune diseases; B-Lymphocytes - immunology; Bone Marrow Cells - cytology; Bone Marrow Cells - immunology; Cell Line, Tumor; Cell surface; CLPTM1L; Deregulation; Gene expression; Humans; Humoral immunity; Identification methods; Immune system; Immunity, Humoral; ITM2C; Lymphocytes; Lymphocytes B; Malignancy; membrane protein; Membrane Proteins - genetics; Membrane Proteins - physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoclonal antibodies; Multiple myeloma; Multiple Myeloma - genetics; Multiple Myeloma - immunology; Mutation; Neoplasm Proteins - genetics; Neoplasm Proteins - physiology; Phenotypes; Phosphatidate Phosphatase - genetics; Phosphatidate Phosphatase - physiology; plasma cell; Plasma Cells - cytology; Plasma Cells - immunology; PLPP5; Primary Cell Culture; Proteins; Transcriptome; membrane protein; PLPP5; antibody; CLPTM1L; plasma cell; ITM2C

Antibody Secreting Cells (ASCs) are a fundamental component of humoral immunity, however, deregulated or excessive antibody production contributes to the pathology of autoimmune diseases, while transformation of ASCs results in the malignancy Multiple Myeloma (MM). Despite substantial recent improve...