Galectins as Molecular Targets for Therapeutic Intervention

Galectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and that function by interacting with various cell surface glycoconjugates, usually targeting β-galactoside epitopes. Because of their significant...

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Published inInternational journal of molecular sciences Vol. 19; no. 3; p. 905
Main Authors Dings, Ruud P M, Miller, Michelle C, Griffin, Robert J, Mayo, Kevin H
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 19.03.2018
MDPI
Subjects
Amino acids
Angiogenesis
Animals
Apoptosis
Binding sites
Biological activity
Cancer
Carbohydrates
Carbohydrates - chemistry
cell adhesion
Cell surface
Chemical bonds
Chemotaxis
Drug Therapy, Combination
Epitopes
galectin-targeted therapeutics
galectins
Galectins - chemistry
Galectins - metabolism
Glycoconjugates
Humans
Lactose
Molecular Targeted Therapy
protein structure
Proteins
Review
Sandwiches
Structure-function relationships
carbohydrates
protein structure
galectins
cell adhesion
apoptosis
galectin-targeted therapeutics
cancer
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Abstract Galectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and that function by interacting with various cell surface glycoconjugates, usually targeting β-galactoside epitopes. Because of their significant involvement in various biological functions and pathologies, galectins have become a focus of therapeutic discovery for clinical intervention against cancer, among other pathological disorders. In this review, we focus on understanding galectin structure-function relationships, their mechanisms of action on the molecular level, and targeting them for therapeutic intervention against cancer.
AbstractList Galectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and that function by interacting with various cell surface glycoconjugates, usually targeting β-galactoside epitopes. Because of their significant involvement in various biological functions and pathologies, galectins have become a focus of therapeutic discovery for clinical intervention against cancer, among other pathological disorders. In this review, we focus on understanding galectin structure-function relationships, their mechanisms of action on the molecular level, and targeting them for therapeutic intervention against cancer.
Author Dings, Ruud P M
Miller, Michelle C
Mayo, Kevin H
Griffin, Robert J
AuthorAffiliation 1 Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; rpmdings@uams.edu (R.P.M.D.); rjgriffin@usma.edu (R.J.G.)
2 Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; mill0935@umn.edu
AuthorAffiliation_xml – name: 2 Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; mill0935@umn.edu
– name: 1 Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; rpmdings@uams.edu (R.P.M.D.); rjgriffin@usma.edu (R.J.G.)
Author_xml – sequence: 1
  givenname: Ruud P M
  orcidid: 0000-0001-7686-1331
  surname: Dings
  fullname: Dings, Ruud P M
  email: rpmdings@uams.edu
  organization: Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. rpmdings@uams.edu
– sequence: 2
  givenname: Michelle C
  orcidid: 0000-0002-7860-5785
  surname: Miller
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  organization: Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. mill0935@umn.edu
– sequence: 3
  givenname: Robert J
  surname: Griffin
  fullname: Griffin, Robert J
  email: rjgriffin@usma.edu
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  givenname: Kevin H
  surname: Mayo
  fullname: Mayo, Kevin H
  email: mayox001@umn.edu
  organization: Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. mayox001@umn.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29562695$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords carbohydrates
protein structure
galectins
cell adhesion
apoptosis
galectin-targeted therapeutics
cancer
Language English
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– name: Basel
PublicationTitle International journal of molecular sciences
PublicationTitleAlternate Int J Mol Sci
PublicationYear 2018
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
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Snippet Galectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and...
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StartPage 905
SubjectTerms Amino acids
Angiogenesis
Animals
Apoptosis
Binding sites
Biological activity
Cancer
Carbohydrates
Carbohydrates - chemistry
cell adhesion
Cell surface
Chemical bonds
Chemotaxis
Drug Therapy, Combination
Epitopes
galectin-targeted therapeutics
galectins
Galectins - chemistry
Galectins - metabolism
Glycoconjugates
Humans
Lactose
Molecular Targeted Therapy
protein structure
Proteins
Review
Sandwiches
Structure-function relationships
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Title Galectins as Molecular Targets for Therapeutic Intervention
URI https://www.ncbi.nlm.nih.gov/pubmed/29562695
https://www.proquest.com/docview/2108450172
https://search.proquest.com/docview/2017056142
https://pubmed.ncbi.nlm.nih.gov/PMC5877766
https://doaj.org/article/b2b3562bde5a44efaabd8dbc9f10b446
Volume 19
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