Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort

• Published in: Biological psychiatry (1969) Vol. 79; no. 5; pp. 383 - 391
• Main Authors: Bertelsen, Birgitte, Stefánsson, Hreinn, Riff Jensen, Lars, Melchior, Linea, Mol Debes, Nanette, Groth, Camilla, Skov, Liselotte, Werge, Thomas, Karagiannidis, Iordanis, Tarnok, Zsanett, Barta, Csaba, Nagy, Peter, Farkas, Luca, Brøndum-Nielsen, Karen, Rizzo, Renata, Gulisano, Mariangela, Rujescu, Dan, Kiemeney, Lambertus A., Tosato, Sarah, Nawaz, Muhammad Sulaman, Ingason, Andres, Unnsteinsdottir, Unnur, Steinberg, Stacy, Ludvigsson, Pétur, Stefansson, Kari, Kuss, Andreas Walter, Paschou, Peristera, Cath, Danielle, Hoekstra, Pieter J., Müller-Vahl, Kirsten, Stuhrmann, Manfred, Silahtaroglu, Asli, Pfundt, Rolph, Tümer, Zeynep
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2016
• Subjects: AADAC; Adult; Animals; Association study; Attention Deficit Disorder with Hyperactivity - genetics; CNV; Cohort Studies; Comorbidity; Copy number variation; Denmark; DNA Copy Number Variations - genetics; Exons; Female; Genotyping Techniques; Germany; Gilles de la Tourette syndrome; Humans; Hungary; Iceland; Italy; Male; Mice; Netherlands; Neuropsychiatric disorder; Psychiatric/Mental Health; Sequence Deletion - genetics; Tourette Syndrome - genetics; Association study; Gilles de la Tourette syndrome; CNV; Copy number variation; AADAC; Neuropsychiatric disorder
• ISSN: 0006-3223; 1873-2402; 1873-2402
• DOI: 10.1016/j.biopsych.2015.08.027

Gilles de la Tourette syndrome (GTS) is a complex neuropsychiatric disorder with a strong genetic influence where copy number variations are suggested to play a role in disease pathogenesis. In a previous small-scale copy number variation study of a GTS cohort (n = 111), recurrent exon-affecting mic...