Fourteen days of bed rest induces a decline in satellite cell content and robust atrophy of skeletal muscle fibers in middle-aged adults

• Published in: Journal of applied physiology (1985) Vol. 120; no. 8; pp. 965 - 975
• Main Authors: Arentson-Lantz, Emily J., English, Kirk L., Paddon-Jones, Douglas, Fry, Christopher S.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.04.2016
• Series: Analogs of Microgravity: Space Research without Leaving the Planet
• Subjects: Astronauts; Bed Rest - adverse effects; Biopsy; Body Composition - physiology; Female; Highlighted Topic; Humans; Immunohistochemistry; Knee - physiology; Male; Middle Aged; Muscle Fibers, Skeletal - physiology; Muscular Atrophy - physiopathology; Musculoskeletal diseases; Myosin Heavy Chains - physiology; Oxygen consumption; Oxygen Consumption - physiology; Physiology; Protein expression; Quadriceps Muscle - physiology; Satellite Cells, Skeletal Muscle - physiology; Space biology; spaceflight; Pax7; capillary; mechanical unloading; myonuclei

Bed rest, a ground-based spaceflight analog, induces robust atrophy of skeletal muscle, an effect that is exacerbated with increasing age. We examined the effect of 14 days of bed rest on skeletal muscle satellite cell content and fiber type atrophy in middle-aged adults, an understudied age demogra...