Dynamic In Vivo Profiling of DNA Damage and Repair after Radiotherapy Using Canine Patients as a Model

• Published in: International journal of molecular sciences Vol. 18; no. 6; p. 1176
• Main Authors: Schulz, Nadine, Chaachouay, Hassan, Nytko, Katarzyna J, Weyland, Mathias S, Roos, Malgorzata, Füchslin, Rudolf M, Guscetti, Franco, Scheidegger, Stephan, Rohrer Bley, Carla
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2017; MDPI
• Subjects: Animals; Cancer therapies; Cell cycle; Comet Assay; Computer simulation; DNA damage; DNA Damage - radiation effects; DNA damage repair; DNA fingerprinting; DNA repair; DNA Repair - radiation effects; DNA repair model; dog; Dogs; Female; Histones - metabolism; Immunohistochemistry; Irradiation; Kinetics; Lymphoma; Male; Mathematical models; Melanoma; Models, Animal; Models, Theoretical; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - radiotherapy; Patients; Phosphorylation; radiation; Radiation Dosage; Radiation therapy; Radiation, Ionizing; Radiotherapy; Repair; Sarcoma; Skin cancer; Tails; Time lag; Tumors; γH2AX-foci; DNA damage repair; comet assay; radiation; γH2AX-foci; kinetics; dog; DNA repair model

Time resolved data of DNA damage and repair after radiotherapy elucidates the relation between damage, repair, and cell survival. While well characterized in vitro, little is known about the time-course of DNA damage response in tumors sampled from individual patients. Kinetics of DNA damage after r...