Global Thrombosis Test (GTT) can detect major determinants of haemostasis including platelet reactivity, endogenous fibrinolytic and thrombin generating potential

• Published in: Thrombosis research Vol. 133; no. 5; pp. 919 - 926
• Main Authors: Yamamoto, J., Inoue, N., Otsui, K., Ishii, H., Gorog, D.A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.05.2014
• Subjects: Aged; Anticoagulant; Antithrombins; Blood Coagulation - drug effects; Blood Coagulation - physiology; Blood Platelets - metabolism; Female; Fibrinolysis; Fibrinolysis - physiology; Hematology, Oncology, and Palliative Medicine; Hemostasis; Humans; Male; Platelet aggregation; Platelet Aggregation - drug effects; Platelet function; Platelet Function Tests - methods; Point-of-Care Systems; Thrombin; Thrombin - antagonists & inhibitors; Thrombin - metabolism; Thrombosis - blood; MP; AF; OT; OT-H; GTT; VTE; NOAC; Thrombin; Anticoagulant; Platelet aggregation; Fibrinolysis; ACS; TF; TG; Antithrombins; Platelet function; PFT; tissue factor; Global Thrombosis Test; atrial fibrillation; acute coronary syndrome; platelet function test; novel oral anticoagulant; microparticles; hemolysis-induced endogenous thrombin potential; occlusion time; venous thromboembolism; thrombin generation

Detection of both thrombosis and bleeding risk are essential in clinical cardiology. Thrombin generated by activated platelets and from the extrinsic coagulation pathway is the major determinant of thrombogenesis and hemostasis. Although novel oral anticoagulants further increase the bleeding risk o...