Macroporous gelatine spheres as culture substrate, transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues. In vivo study in nude mice
Summary In the course of development of a new type of filler for the correction of small defects in soft tissues we studied macroporous gelatine spheres as culture substrate, transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues in vivo. We injected intradermall...
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| Published in | Journal of plastic, reconstructive & aesthetic surgery Vol. 60; no. 5; pp. 543 - 555 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier Ltd
01.01.2007
Elsevier |
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| Abstract | Summary In the course of development of a new type of filler for the correction of small defects in soft tissues we studied macroporous gelatine spheres as culture substrate, transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues in vivo. We injected intradermally in nude mice gelatine spheres that had either been preseeded with human fibroblasts or preadipocytes, or left unseeded. We compared the extent of regenerated tissue with that found after injections of saline or single-cell suspensions of human fibroblasts or preadipocytes. Routine histological examinations and immunohistochemical staining for von Willebrand factor (indicating neoangiogenesis) were made after 7, 21, and 56 days. Injected saline or single-cell suspensions had no effect. However, a quick and thorough tissue regeneration with developing neoangiogenesis was elicited by the gelatine spheres and the effect of spheres preseeded with preadipocytes surpassed the effect of spheres preseeded with fibroblasts, which in turn surpassed the effect of unseeded gelatine spheres. We suggest that minor soft tissue defects such as wrinkles or creases can be corrected by injection of naked macroporous gelatine spheres, whereas larger defects are best corrected by injection of macroporous gelatine spheres preseeded with fibroblasts, or preadipocytes, or both. |
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| AbstractList | In the course of development of a new type of filler for the correction of small defects in soft tissues we studied macroporous gelatine spheres as culture substrate, transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues in vivo. We injected intradermally in nude mice gelatine spheres that had either been preseeded with human fibroblasts or preadipocytes, or left unseeded. We compared the extent of regenerated tissue with that found after injections of saline or single-cell suspensions of human fibroblasts or preadipocytes. Routine histological examinations and immunohistochemical staining for von Willebrand factor (indicating neoangiogenesis) were made after 7, 21, and 56 days. Injected saline or single-cell suspensions had no effect. However, a quick and thorough tissue regeneration with developing neoangiogenesis was elicited by the gelatine spheres and the effect of spheres preseeded with preadipocytes surpassed the effect of spheres preseeded with fibroblasts, which in turn surpassed the effect of unseeded gelatine spheres. We suggest that minor soft tissue defects such as wrinkles or creases can be corrected by injection of naked macroporous gelatine spheres, whereas larger defects are best corrected by injection of macroporous gelatine spheres preseeded with fibroblasts, or preadipocytes, or both. Summary In the course of development of a new type of filler for the correction of small defects in soft tissues we studied macroporous gelatine spheres as culture substrate, transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues in vivo. We injected intradermally in nude mice gelatine spheres that had either been preseeded with human fibroblasts or preadipocytes, or left unseeded. We compared the extent of regenerated tissue with that found after injections of saline or single-cell suspensions of human fibroblasts or preadipocytes. Routine histological examinations and immunohistochemical staining for von Willebrand factor (indicating neoangiogenesis) were made after 7, 21, and 56 days. Injected saline or single-cell suspensions had no effect. However, a quick and thorough tissue regeneration with developing neoangiogenesis was elicited by the gelatine spheres and the effect of spheres preseeded with preadipocytes surpassed the effect of spheres preseeded with fibroblasts, which in turn surpassed the effect of unseeded gelatine spheres. We suggest that minor soft tissue defects such as wrinkles or creases can be corrected by injection of naked macroporous gelatine spheres, whereas larger defects are best corrected by injection of macroporous gelatine spheres preseeded with fibroblasts, or preadipocytes, or both. |
| Author | Kratz, Gunnar Johnson, Hans Junker, Johan P.E Huss, Fredrik R.M |
| Author_xml | – sequence: 1 fullname: Huss, Fredrik R.M – sequence: 2 fullname: Junker, Johan P.E – sequence: 3 fullname: Johnson, Hans – sequence: 4 fullname: Kratz, Gunnar |
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| Keywords | In vivo Soft tissue defect Tissue engineering Filler Animal Guided tissue regeneration Rodentia Absorbable Transplantation Guidance Substrate Regeneration Tissue Vertebrata Mammalia Treatment Mouse Surgery Graft Soft tissue Culture |
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| Snippet | Summary In the course of development of a new type of filler for the correction of small defects in soft tissues we studied macroporous gelatine spheres as... In the course of development of a new type of filler for the correction of small defects in soft tissues we studied macroporous gelatine spheres as culture... |
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| SubjectTerms | Absorbable Implants Adipocytes Animal Animals Biocompatible Materials Biological and medical sciences Cell Transplantation - methods Cells, Cultured Culture Media Female Fibroblasts Filler Gelatin Guided tissue regeneration Guided Tissue Regeneration - methods Humans Immunohistochemistry - methods In Situ Hybridization, Fluorescence - methods In vivo Medical sciences MEDICIN MEDICINE Mice Mice, Nude Microspheres Plastic Surgery Regeneration Soft tissue defect Soft Tissue Injuries - pathology Soft Tissue Injuries - physiopathology Soft Tissue Injuries - surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Engineering |
| Title | Macroporous gelatine spheres as culture substrate, transplantation vehicle, and biodegradable scaffold for guided regeneration of soft tissues. In vivo study in nude mice |
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