MicroRNAs as Biomarkers in Amyotrophic Lateral Sclerosis

• Published in: Cells (Basel, Switzerland) Vol. 7; no. 11; p. 219
• Main Authors: Ricci, Claudia, Marzocchi, Carlotta, Battistini, Stefania
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.11.2018; MDPI
• Subjects: Age; Alzheimer's disease; Amyotrophic lateral sclerosis; amyotrophic lateral sclerosis (ALS); biomarker; Biomarkers; Body fluids; Brain stem; Cerebral cortex; Cerebrospinal fluid; cerebrospinal fluid (CSF); circulating miRNAs; Gene expression; Laboratories; Medical research; Metabolism; microRNA; MicroRNAs; miRNA; Motor neurons; muscle biopsy; Neurodegeneration; Neurodegenerative diseases; Neurological diseases; Neurons; Pathogenesis; Patients; Review; Spinal cord; microRNA; cerebrospinal fluid (CSF); biomarker; muscle biopsy; amyotrophic lateral sclerosis (ALS); circulating miRNAs
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells7110219

Amyotrophic lateral sclerosis (ALS) is an incurable and fatal disorder characterized by the progressive loss of motor neurons in the cerebral cortex, brain stem, and spinal cord. Sporadic ALS form accounts for the majority of patients, but in 1–13.5% of cases the disease is inherited. The diagnosis...