Regulation of Prolactin Receptor Gene Expression in the Rat Choroid Plexus via Transcriptional Activation of Multiple First Exons during Postnatal Development and Lactation
Prolactin (PRL) has numerous physiological functions that are mediated by its receptors in target cells. Expression of the rat PRL receptor (PRLR) gene is regulated in a tissue-specific manner via the transcriptional activation of five distinct first exons, i.e., E11, E12, E13, E14, and E15. In the...
Saved in:
| Published in | Experimental Animals Vol. 62; no. 1; pp. 49 - 56 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Japanese Association for Laboratory Animal Science
2013
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Prolactin (PRL) has numerous physiological functions that are mediated by its receptors in target cells. Expression of the rat PRL receptor (PRLR) gene is regulated in a tissue-specific manner via the transcriptional activation of five distinct first exons, i.e., E11, E12, E13, E14, and E15. In the present study, we investigated the expression profiles of these first exon variants of PRLR mRNA in the rat choroid plexus, which is considered to be a site of receptor-mediated PRL transport from the blood to cerebrospinal fluid. Real-time PCR analysis revealed that E13-, E14-, and E15-PRLR mRNA expression levels increased in the choroid plexus in male and female rats during postnatal development, with markedly higher level of E14-PRLR mRNA. In female rats, the E14-PRLR mRNA expression levels increased markedly during lactation compared with the diestrus state, whereas there was no increase in the E13- and E15-PRLR mRNA levels. The E14-PRLR mRNA expression pattern was similar to that of the total PRLR mRNA. The PRL plasma concentration generally correlated with the E14-PRLR mRNA expression levels in both sexes. These findings suggest that PRLR gene expression in the choroid plexus is upregulated mainly via the transcriptional activation of the E14-first exon. |
|---|---|
| AbstractList | Prolactin (PRL) has numerous physiological functions that are mediated by its receptors in target cells. Expression of the rat PRL receptor (PRLR) gene is regulated in a tissue-specific manner via the transcriptional activation of five distinct first exons, i.e., E1(1), E1(2), E1(3), E1(4), and E1(5). In the present study, we investigated the expression profiles of these first exon variants of PRLR mRNA in the rat choroid plexus, which is considered to be a site of receptor-mediated PRL transport from the blood to cerebrospinal fluid. Real-time PCR analysis revealed that E1(3)-, E1(4)-, and E1(5)-PRLR mRNA expression levels increased in the choroid plexus in male and female rats during postnatal development, with markedly higher level of E1(4)-PRLR mRNA. In female rats, the E1(4)-PRLR mRNA expression levels increased markedly during lactation compared with the diestrus state, whereas there was no increase in the E1(3)- and E1(5)-PRLR mRNA levels. The E1(4)-PRLR mRNA expression pattern was similar to that of the total PRLR mRNA. The PRL plasma concentration generally correlated with the E1(4)-PRLR mRNA expression levels in both sexes. These findings suggest that PRLR gene expression in the choroid plexus is upregulated mainly via the transcriptional activation of the E1(4)-first exon. Prolactin (PRL) has numerous physiological functions that are mediated by its receptors in target cells. Expression of the rat PRL receptor (PRLR) gene is regulated in a tissue-specific manner via the transcriptional activation of five distinct first exons, i.e., E1 sub(1), E1 sub(2), E1 sub(3), E1 sub(4), and E1 sub(5). In the present study, we investigated the expression profiles of these first exon variants of PRLR mRNA in the rat choroid plexus, which is considered to be a site of receptor-mediated PRL transport from the blood to cerebrospinal fluid. Real-time PCR analysis revealed that E1 sub(3)-, E1 sub(4)-, and E1 sub(5)-PRLR mRNA expression levels increased in the choroid plexus in male and female rats during postnatal development, with markedly higher level of E1 sub(4)-PRLR mRNA. In female rats, the E1 sub(4)-PRLR mRNA expression levels increased markedly during lactation compared with the diestrus state, whereas there was no increase in the E1 sub(3)- and E1 sub(5)-PRLR mRNA levels. The E1 sub(4)-PRLR mRNA expression pattern was similar to that of the total PRLR mRNA. The PRL plasma concentration generally correlated with the E1 sub(4)-PRLR mRNA expression levels in both sexes. These findings suggest that PRLR gene expression in the choroid plexus is upregulated mainly via the transcriptional activation of the E1 sub(4)-first exon. Prolactin (PRL) has numerous physiological functions that are mediated by its receptors in target cells. Expression of the rat PRL receptor (PRLR) gene is regulated in a tissue-specific manner via the transcriptional activation of five distinct first exons, i.e., E11, E12, E13, E14, and E15. In the present study, we investigated the expression profiles of these first exon variants of PRLR mRNA in the rat choroid plexus, which is considered to be a site of receptor-mediated PRL transport from the blood to cerebrospinal fluid. Real-time PCR analysis revealed that E13-, E14-, and E15-PRLR mRNA expression levels increased in the choroid plexus in male and female rats during postnatal development, with markedly higher level of E14-PRLR mRNA. In female rats, the E14-PRLR mRNA expression levels increased markedly during lactation compared with the diestrus state, whereas there was no increase in the E13- and E15-PRLR mRNA levels. The E14-PRLR mRNA expression pattern was similar to that of the total PRLR mRNA. The PRL plasma concentration generally correlated with the E14-PRLR mRNA expression levels in both sexes. These findings suggest that PRLR gene expression in the choroid plexus is upregulated mainly via the transcriptional activation of the E14-first exon. |
| Author | NAKAO, Nobuhiro HIRAI, Junko NISHITA, Masahiro TANAKA, Minoru SAITO, Toru R. |
| Author_xml | – sequence: 1 fullname: HIRAI, Junko organization: Laboratory of Animal Physiology, Graduate School of Veterinary Medicine and Life Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan – sequence: 2 fullname: NISHITA, Masahiro organization: Laboratory of Animal Physiology, Graduate School of Veterinary Medicine and Life Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan – sequence: 3 fullname: NAKAO, Nobuhiro organization: Laboratory of Animal Physiology, Graduate School of Veterinary Medicine and Life Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan – sequence: 4 fullname: SAITO, Toru R. organization: Laboratory of Behavioral Neuroscience, Graduate School of Veterinary Medicine and Life Science, Nippon Veterinary and Animal Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan – sequence: 5 fullname: TANAKA, Minoru organization: Laboratory of Animal Physiology, Graduate School of Veterinary Medicine and Life Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23357946$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkcuO0zAUQC00iHnAki3ykk2KX4mT5ah0BqQiqmpYR45z03rk2sF2qs4_8ZG401Kxsa17j4_u4xZdOe8AoY-UzGjJ6y9wGJUzu1nFZqJ5g25oXdNCUsau8psLWlBeymt0G-MzIUxK1rxD14znYCOqG_RnDZvJqmS8w37Aq-Ct0sk4vAYNY_IBP4IDvDiMAWI8UjmXtoDXKuH51gdveryycJgi3huFn4JyUQczHo3K4vss21_0PyabzGgBP5gQU7Z6F3E_BeM2eOVjcirlP19hD9aPO3AJK9fjZa7oVfEevR2UjfDhfN-hXw-Lp_m3Yvnz8fv8flnoUohUVPVQN13VawmEctINNLddkYH1ohw0kV1Tsr6shNSiq3g3gMyz6CQRAy1rIhS_Q59P3jH43xPE1O5M1GCtcuCn2ObBi5rKijcZLU6oDj7GAEM7BrNT4aWl5MjV7XlBbcVaceQ_ndVTt4P-Qv_bSAYWJ-A5JrWBC6BCMtrC_zr6erCWkJJf8nqrQguO_wVkmqwI |
| CitedBy_id | crossref_primary_10_1016_j_physbeh_2014_10_036 crossref_primary_10_1016_j_brainres_2014_04_018 crossref_primary_10_31829_2691_5502_avs2018_1_1__101 crossref_primary_10_1007_s00441_018_2858_2 crossref_primary_10_1007_s12020_017_1346_x crossref_primary_10_1016_j_yfrne_2021_100913 crossref_primary_10_1530_JME_14_0212 crossref_primary_10_1159_000354701 |
| Cites_doi | 10.1210/endo-120-5-1846 10.1677/jme.0.0230013 10.1677/jme.1.01702 10.1074/jbc.272.22.14263 10.1210/mend-3-4-674 10.1677/jme.0.0300031 10.1002/cne.22208 10.1210/er.19.3.225 10.1210/endo.143.6.8826 10.1210/mend-4-8-1136 10.1016/0018-506X(88)90030-X 10.1677/joe.0.1490335 10.1210/en.133.1.135 10.1080/07435800701764022 10.1074/jbc.273.40.26225 10.1016/0006-8993(94)91269-6 10.1111/j.1365-2826.1994.tb00572.x 10.1210/me.10.6.661 10.1677/jme.0.0310221 10.1210/en.130.3.1747 10.1210/en.136.12.5608 10.3109/07435807609073912 10.1210/en.131.2.698 10.1002/(SICI)1096-9861(19970922)386:2<161::AID-CNE1>3.0.CO;2-# 10.1016/S0021-9258(17)36838-2 10.1210/endo-93-3-660 10.1159/000069510 10.1016/0169-328X(92)90207-R 10.1016/0378-1119(93)90104-B 10.1111/j.1365-2826.2007.01565.x 10.1016/0006-8993(92)90599-5 10.1210/en.137.2.631 |
| ContentType | Journal Article |
| Copyright | 2013 Japanese Association for Laboratory Animal Science |
| Copyright_xml | – notice: 2013 Japanese Association for Laboratory Animal Science |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 8FD FR3 P64 RC3 |
| DOI | 10.1538/expanim.62.49 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Genetics Abstracts Engineering Research Database Technology Research Database Biotechnology and BioEngineering Abstracts |
| DatabaseTitleList | MEDLINE Genetics Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Zoology |
| EISSN | 1881-7122 |
| EndPage | 56 |
| ExternalDocumentID | 10_1538_expanim_62_49 23357946 article_expanim_62_1_62_12_0053_article_char_en |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .55 29G 2WC 3O- 53G 5GY AAUGY ACGFO ACIWK ACPRK ADBBV ADRAZ AENEX AFRAH ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL CS3 DIK DU5 E3Z EMOBN FRP GX1 HYE JSF JSH KQ8 M48 M~E OK1 P2P RJT RNS RPM RZJ TKC TR2 X7M XSB CGR CUY CVF ECM EIF NPM AAYXX CITATION PGMZT 8FD FR3 P64 RC3 |
| ID | FETCH-LOGICAL-c544t-68f89b6dc7e0130bf177260f2d45fc07b952d5647c4b63bfe7794b704f15804a3 |
| IEDL.DBID | M48 |
| ISSN | 1341-1357 |
| IngestDate | Thu Aug 15 23:44:21 EDT 2024 Fri Aug 23 03:09:13 EDT 2024 Fri Sep 17 22:56:48 EDT 2021 Thu Aug 17 20:24:37 EDT 2023 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c544t-68f89b6dc7e0130bf177260f2d45fc07b952d5647c4b63bfe7794b704f15804a3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1538/expanim.62.49 |
| PMID | 23357946 |
| PQID | 1534817639 |
| PQPubID | 23462 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1534817639 crossref_primary_10_1538_expanim_62_49 pubmed_primary_23357946 jstage_primary_article_expanim_62_1_62_12_0053_article_char_en |
| PublicationCentury | 2000 |
| PublicationDate | 2013 2013-00-00 20130101 |
| PublicationDateYYYYMMDD | 2013-01-01 |
| PublicationDate_xml | – year: 2013 text: 2013 |
| PublicationDecade | 2010 |
| PublicationPlace | Japan |
| PublicationPlace_xml | – name: Japan |
| PublicationTitle | Experimental Animals |
| PublicationTitleAlternate | Exp Anim |
| PublicationYear | 2013 |
| Publisher | Japanese Association for Laboratory Animal Science |
| Publisher_xml | – name: Japanese Association for Laboratory Animal Science |
| References | 3. Bakowska, J.C. and Morrell, J.I. 1997. Atlas of the neurons that express mRNA forthe long form of the prolactin receptor in the forebrain of the female rat. J. Comp. Neurol. 386: 161-177. 23. Moore, R.C. and Oka, T. 1993. Cloning and sequencing of the cDNA encoding the murine mammary gland long-form prolactin receptor. Gene 134: 263-265. 25. Nagano, M. and Kelly, P.A. 1994. Tissue distribution and regulation of rat prolactin receptor gene expression. Quantitative analysis by polymerase chain reaction. J. Biol. Chem. 269: 13337-13345. 33. Sugiyama, T., Minoura, H., Toyoda, N., Sakaguchi, K., Tanaka, M., Sudo, S., and Nakashima, K. 1996. Pup contact induces the expression of long form prolactin receptor mRNA in the brain of female rats: effects of ovariectomy and hypophysectomy on receptor gene expression. J. Endocrinol. 149: 335-340. 5. Bole-Feysot, C., Goffin, V., Edery, M., Binart, N., and Kelly, P.A. 1998. Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr. Rev.,19: 225-268. 12. Di Carlo, R., Muccioli, G., Papotti, M., and Bussolati, G. 1992. Characterization of prolactin receptor in human brain and choroid plexus. Brain Res. 570: 341-346. 4. Bakowska, J.C. and Morrell, J.I. 2003. The distribution of mRNA for the short form of the prolactin receptor in the forebrain of the female rat. Brain Res. Mol. Brain Res.,116: 50-58. 11. Davis, J.A. and Linzer, D.I. 1989. Expression of multiple forms of the prolactin receptor in mouse liver. Mol. Endocrinol. 3: 674-680. 31. Pi, X.J. and Grattan, D.R. 1999. Increased expression of both short and long forms of prolactin receptor mRNA in hypothalamic nuclei of lactating rats. J. Mol. Endocrinol. 23: 13-22. 10. Das, R. and Vonderhaar, B.K. 1995. Transduction of prolactin’s (PRL) growth signal through both long and short forms of the PRL receptor. Mol. Endocrinol.,9: 1750-1759. 22. Moldrup, A., Ormandy, C., Nagano, M., Murthy, K., Banville, D., Tronche, F., and Kelly, P.A. 1996. Differential promoter usage in prolactin receptor gene expression: hepatocyte nuclear factor 4 binds to and activates the prpmoter preferentially active in the liver. Mol. Endocrinol. 10: 661-671. 27. Nogami, H., Hoshino, R., Ogasawara, K., Miyamoto, S., and Hisano, S. 2007. Region-specific expression and hormonal regulation of the first exon variants of rat prolactin receptor mRNA in rat brain and anterior pituitary gland. J. Neuroendocrinol. 19: 583-593. 18. Hu, Z.Z., Zhuang, L., Meng, J., and Dufau, M.L. 1998. Transcriptional regulation of the generic promoter III of the rat prolactin receptor gene by C/EBPβ and SP1. J. Biol. Chem. 273: 26225-26235. 17. Hu, Z., Zhuang, L., Guan, X., Meng, J., and Dufau, M. 1997. Steroidgenic factor-1 is an essential transcriptional activator for gonad-specific expression of promoter I of the rat prolactin receptor gene. J. Biol. Chem. 272: 14263-14271. 37. Walsh, R.J., Slaby, F.J., and Posner, B.I. 1987. A receptor-mediated mechanism for the transport of prolactin from blood to cerebrospinal fluid. Endocrinology 120: 1846-1850. 15. Fujikawa, T., Soya, H., Yoshizato, H., Sakaguchi, K., Doh-Ura, K., Tanaka, M., and Nakashima, K. 1995. Restraint stress enhances the gene expression of prolactin receptor long form at the choroid plexus. Endocrinology 136: 5608-5613. 32. Shirota, M., Banville, D., Ali, S., Jolicoeur, C., Boutin, J.M., Edery, M., Djiane, J., and Kelly, P.A. 1990. Expression of two forms of prolactin receptor in rat ovary and liver. Mol. Endocrinol. 4: 1136-1143. 36. Trott, J.F., Hovey, R.C., Koduri, S., and Vonderhaar, B.K. 2003. Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein. J. Mol. Endocrinol. 30: 31-47. 24. Muccioli, G. and Di Carlo, R. 1994. Modulation of prolactin receptors in the rat hypothalamus in response to changes in serum concentration of endogenous prolactin or to ovine prolactin administration. Brain Res. 663: 244-250. 30. Pi, X., Zhang, B., Li, J., and Voogt, J.L. 2003. Promoter usage and estrogen regulation of prolactin receptor gene in the brain of the female rat. Neuroendocrinology 77: 187-197. 20. Kobayashi, M., Suzuki, M., Saito, T.R., and Tanaka, M. 2007. Developmental changes in the expression levels of alternative first exons of prolactin receptor gene in rat brain. Endocr. Res. 32: 143-151. 7. Brown, R.S., Kokay, I.C., Herbison, A.E., and Grattan, D.R. 2010. Distribution of prolactin-responsive neurons in the mouse forebrain. J. Comp. Neurol. 518: 92-102. 2. Augustine, R.A., Kokay, I.C., Andrews, Z.B., Ladyman, S.R., and Grattan, D.R. 2003. Quantitation of prolactin receptor mRNA in the maternal rat brain during pregnancy and lactation. J. Mol. Endocrinol. 31: 221-232. 16. Hu, Z., Zhuang, L., and Dufau, M.L. 1996. Multiple and tissue-specific promoter control of gonadal and non-gonadal prolactin receptor gene expression. J. Biol. Chem. 271: 10242-10246. 13. Escalada, J., Cacicedo, L., Ortego, J., Melian, E., and Sánchez-Franco, F. 1996. Prolactin gene expression and secretion during pregnancy and lactation in the rat: role of dopamine and vasoactive intestinal peptide. Endocrinology 137: 631-637. 8. Chiu, S., Koos, R.D., and Wise, P.M. 1992. Detection of prolactin receptor (PRL-R) mRNA in the rat hypothalamus and pituitary gland. Endocrinology 130: 1747-1749. 1. Anderson, G.M., Kieser, D.C., Steyn, F.J., and Grattan, D.R. 2008. Hypothalamic prolactin receptor messenger ribonucleic acid levels, prolactin signaling, and hyperprolactinemic inhibition of pulsatile luteinizing hormone secretion are dependent on estradiol. Endocrinology 149: 1562-1570. 35. Tanaka, M., Suzuki, M., Kawana, T., Segawa, M., Yoshikawa, M., Mori, M., Kobayashi, M., Nakai, N., and Saito, T.R. 2005. Differential effects of sex steroid hormones on the expressions of multiple first exons including a novel first exon of prolactin receptor gene in the rat liver. J. Mol. Endocrinol. 34: 667-673. 14. Freeman, M.E., Kanyicska, B., Lerant, A., and Nagy, G. 2000. Prolactin: structure, function, and regulation of secretion. Physiol. Rev. 80: 1523-1631. 6. Brooks, P.J., Funabashi, T., Kleopoulos, S.P., Mobbs, C.V., and Pfaff, D.W. 1992. Prolactin receptor messenger RNA is synthesized by the epithelial cells of the choroid plexus. Brain Res. Mol. Brain Res. 16: 163-167. 28. Ojeda, S.R., Klulich, L., and Jameson, H.E. 1976. Developmental patterns of plasma and pituitary TSH and prolactin and hypothalamic TRH in the female rat. Endocr. Res. Commun. 3: 387-406. 29. Ouhtit, A., Morel, G., and Kelly, P.A. 1993. Visualization of gene expression of short and long forms of prolactin receptor in the rat. Endocrinology 133: 135-144. 34. Tanaka, M., Hayashida, Y., Iguchi, T., Nakao, N., Suzuki, M., Nakai, N., and Nakashima, K. 2002. Identification of a novel first exon of prolactin receptor gene expressed in the rat brain. Endocrinology 143: 2080-2084. 21. Mangurian, L.P., Walsh, R.J., and Posner, B.I. 1992. Prolactin enhancement of its own uptake at the choroid plexus. Endocrinology 131: 698-702. 19. Kinsley, C.H. and Bridges, R.S. 1988. Prolactin modulation of the maternal-like behavior displayed by juvenile rats. Horm. Behav. 22: 49-65. 26. Negro-Vilar, A., Krulich, L., and McCann, S.M. 1973. Changes in serum prolactin and gonadotropins during sexual development of the male rat. Endocrinology 93: 660-664. 9. Chiu, S. and Wise, P.M. 1994. Prolactin receptor mRNA localization in the hypothalamus by in situ hybridization. J. Neuroendocrinol. 6: 191-199. 22 23 24 25 26 27 28 29 30 31 10 32 11 33 12 34 13 35 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 21 |
| References_xml | – ident: 35 doi: 10.1210/endo-120-5-1846 – ident: 29 doi: 10.1677/jme.0.0230013 – ident: 4 – ident: 33 doi: 10.1677/jme.1.01702 – ident: 15 doi: 10.1074/jbc.272.22.14263 – ident: 10 doi: 10.1210/mend-3-4-674 – ident: 34 doi: 10.1677/jme.0.0300031 – ident: 7 doi: 10.1002/cne.22208 – ident: 5 doi: 10.1210/er.19.3.225 – ident: 32 doi: 10.1210/endo.143.6.8826 – ident: 30 doi: 10.1210/mend-4-8-1136 – ident: 17 doi: 10.1016/0018-506X(88)90030-X – ident: 31 doi: 10.1677/joe.0.1490335 – ident: 27 doi: 10.1210/en.133.1.135 – ident: 18 doi: 10.1080/07435800701764022 – ident: 16 doi: 10.1074/jbc.273.40.26225 – ident: 22 doi: 10.1016/0006-8993(94)91269-6 – ident: 9 doi: 10.1111/j.1365-2826.1994.tb00572.x – ident: 1 – ident: 20 doi: 10.1210/me.10.6.661 – ident: 2 doi: 10.1677/jme.0.0310221 – ident: 8 doi: 10.1210/en.130.3.1747 – ident: 14 doi: 10.1210/en.136.12.5608 – ident: 26 doi: 10.3109/07435807609073912 – ident: 19 doi: 10.1210/en.131.2.698 – ident: 3 doi: 10.1002/(SICI)1096-9861(19970922)386:2<161::AID-CNE1>3.0.CO;2-# – ident: 13 – ident: 23 doi: 10.1016/S0021-9258(17)36838-2 – ident: 24 doi: 10.1210/endo-93-3-660 – ident: 28 doi: 10.1159/000069510 – ident: 6 doi: 10.1016/0169-328X(92)90207-R – ident: 21 doi: 10.1016/0378-1119(93)90104-B – ident: 25 doi: 10.1111/j.1365-2826.2007.01565.x – ident: 11 doi: 10.1016/0006-8993(92)90599-5 – ident: 12 doi: 10.1210/en.137.2.631 |
| SSID | ssj0027729 |
| Score | 2.0181158 |
| Snippet | Prolactin (PRL) has numerous physiological functions that are mediated by its receptors in target cells. Expression of the rat PRL receptor (PRLR) gene is... |
| SourceID | proquest crossref pubmed jstage |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 49 |
| SubjectTerms | Animals choroid plexus Choroid Plexus - metabolism Exons - genetics Female Gene Expression Regulation, Developmental Lactation - genetics Male prolactin prolactin receptor gene rat Rats Rats, Wistar - growth & development Rats, Wistar - physiology Receptors, Prolactin - genetics transcription Transcription, Genetic |
| Title | Regulation of Prolactin Receptor Gene Expression in the Rat Choroid Plexus via Transcriptional Activation of Multiple First Exons during Postnatal Development and Lactation |
| URI | https://www.jstage.jst.go.jp/article/expanim/62/1/62_12-0053/_article/-char/en https://www.ncbi.nlm.nih.gov/pubmed/23357946 https://search.proquest.com/docview/1534817639 |
| Volume | 62 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Experimental Animals, 2013, Vol.62(1), pp.49-56 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwELZgAYkL4k15aZAQt5TGz-QACK22WiG6qlZUWnGJbMeGoiVZ-kDlP_EjmXHS7iLgxMUXJ57E4xnPjMfzMfbcekIl5CKzVpWZrAkN0BuZee5jEYUwzqVsiyN9OJPvTtTJeUmhfgKXf3XtCE9qtjgdbr79eIMC_yqh94jiZdig4My_DjUfyvIyu8KlkLTYJ7I4971MAiyj8mVZLpTpy23-8fpv29PVL2ihfQr_Nj7TJjS-yW701iO87dh9i10KzW127WObYuN32M_jDlke5xraCNMF_hzqswbQOAxn6F0DVZmGg02f_doA9qEFCMd2Bfuf20U7r2F6GjbrJXyfW0gb2VatEF2_BUOj4Sd9LiKM52hC4qi4gKG79giEAdxQZAguZCWBbWp4j1-UhrjLZuODD_uHWQ_HkHkl5SrTRSxKp2tvAh13upjjpOpR5LVU0Y-MKxWvlZbGS6eFi8GgrDszkjFXxUhacY_tNW0THjCIeRHRN6MQikcPzVkltBU5NxHbMtYD9mLLheqsq7pRkbeC7Kp6dlWaV7IcsNcdj3aP9QJ38bE8NbwihbPrp0ttqBkG7NmWtxUKFp2W2Ca06yURk0WO6heJ3O-YviPCBS6hUuqH_0v-EbvOE74GxXQes73VYh2eoJWzck_T-sX2aDr5BVfrA8Q |
| link.rule.ids | 315,786,790,2236,4043,24346,27956,27957,27958 |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Regulation+of+Prolactin+Receptor+Gene+Expression+in+the+Rat+Choroid+Plexus+via+Transcriptional+Activation+of+Multiple+First+Exons+during+Postnatal+Development+and+Lactation&rft.jtitle=Experimental+Animals&rft.au=HIRAI%2C+Junko&rft.au=NISHITA%2C+Masahiro&rft.au=NAKAO%2C+Nobuhiro&rft.au=SAITO%2C+Toru+R.&rft.date=2013&rft.pub=Japanese+Association+for+Laboratory+Animal+Science&rft.issn=1341-1357&rft.eissn=1881-7122&rft.volume=62&rft.issue=1&rft.spage=49&rft.epage=56&rft_id=info:doi/10.1538%2Fexpanim.62.49&rft.externalDocID=article_expanim_62_1_62_12_0053_article_char_en |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1341-1357&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1341-1357&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1341-1357&client=summon |