Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity

• Published in: Journal of lipid research Vol. 50; no. 2; pp. 183 - 192
• Main Authors: Nakanishi, Shuhei, Vikstedt, Riikka, Söderlund, Sanni, Lee-Rueckert, Miriam, Hiukka, Anne, Ehnholm, Christian, Muilu, Mikko, Metso, Jari, Naukkarinen, Jussi, Palotie, Leena, Kovanen, Petri T., Jauhiainen, Matti, Taskinen, Marja-Riitta
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2009; American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Adult; atherosclerosis; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Cells, Cultured; Cholesterol - blood; Cholesterol - metabolism; Cholesterol, HDL - blood; Female; Foam Cells - cytology; Foam Cells - metabolism; Humans; lipoproteins; Macrophages - metabolism; Male; Middle Aged; Monocytes - metabolism; reverse cholesterol transport; RNA, Messenger - metabolism; atherosclerosis; reverse cholesterol transport; lipoproteins

The main antiatherogenic function of HDL is to promote the efflux of cholesterol from peripheral cells and transport it to the liver for excretion in a process termed reverse cholesterol transport. The aim of this study was to evaluate the cholesterol efflux capacity in low- and high-HDL subjects by...