Tissue-nonspecific Alkaline Phosphatase Promotes the Neurotoxicity Effect of Extracellular Tau

• Published in: The Journal of biological chemistry Vol. 285; no. 42; pp. 32539 - 32548
• Main Authors: Díaz-Hernández, Miguel, Gómez-Ramos, Alberto, Rubio, Alicia, Gómez-Villafuertes, Rosa, Naranjo, José R., Miras-Portugal, M. Teresa, Avila, Jesús
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.10.2010; American Society for Biochemistry and Molecular Biology
• Subjects: Acetylcholine receptors (muscarinic); Aged; Aged, 80 and over; Alkaline Phosphatase; Alkaline Phosphatase - metabolism; Alzheimer Disease; Alzheimer Disease - metabolism; Alzheimer's disease; Animals; Brain; Brain - enzymology; Calcium; Calcium (intracellular); Calcium - metabolism; Calcium Homeostasis; Cell Line, Tumor - drug effects; Central nervous system; Dephosphorylation; Enzymes; Extracellular levels; Extracellular Tau; Female; Hippocampus; Humans; Male; Mice; Molecular Bases of Disease; Neurobiology; Neuroblastoma cells; Neurodegeneration; Neurodegenerative diseases; Neurofibrillary tangles; Neurons; Neurotoxicity; Phosphatase; Tau; Tau protein; tau Proteins - pharmacology; tau Proteins - toxicity; Transcription; Calcium; Neurodegeneration; Tau; Calcium Homeostasis; Alkaline Phosphatase; Dephosphorylation; Alzheimer Disease; Phosphatase; Extracellular Tau

There is solid evidence indicating that hyperphosphorylated tau protein, the main component of intracellular neurofibrillary tangles present in the brain of Alzheimer disease patients, plays a key role in progression of this disease. However, it has been recently reported that extracellular unmodifi...