Application of Prostate Cancer Models for Preclinical Study: Advantages and Limitations of Cell Lines, Patient-Derived Xenografts, and Three-Dimensional Culture of Patient-Derived Cells

• Published in: Cells (Basel, Switzerland) Vol. 8; no. 1; p. 74
• Main Authors: Namekawa, Takeshi, Ikeda, Kazuhiro, Horie-Inoue, Kuniko, Inoue, Satoshi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.01.2019; MDPI
• Subjects: Androgens; Animals; Cancer therapies; Cell culture; Cell Culture Techniques - methods; cell line; Cell Line, Tumor; Cytokeratin; Drug resistance; Drug Resistance, Neoplasm; Extracellular matrix; Gene expression; Humans; Immunodeficiency; Male; Metastases; Metastasis; Mutation; organoid; Organoids; patient-derived xenograft; Patients; Precision medicine; Prostate cancer; Prostatic Neoplasms - pathology; Review; spheroid; Tissue engineering; Transplantation; Tumor cell lines; Tumorigenesis; Tumors; Xenograft Model Antitumor Assays; Xenografts; United States > US; prostate cancer; patient-derived xenograft; cell line; organoid; spheroid

Various preclinical models have been developed to clarify the pathophysiology of prostate cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by DU-145, PC-3, and LNCaP cells, are useful tools to define mechanisms underlying tumorigenesis and drug resistance. Ce...