The Effects of the WNT-Signaling Modulators BIO and PKF118-310 on the Chondrogenic Differentiation of Human Mesenchymal Stem Cells

• Published in: International journal of molecular sciences Vol. 19; no. 2; p. 561
• Main Authors: Huang, Xiaobin, Zhong, Leilei, Hendriks, Jan, Post, Janine N, Karperien, Marcel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.02.2018; MDPI
• Subjects: Apoptosis; Bone marrow; Cartilage; Cbfa-1 protein; Cell culture; Chondrogenesis; Collagen (type I); Collagen (type II); Collagenase 3; Deposition; Differentiation; Dkk1 protein; Embryos; Enzyme-linked immunosorbent assay; Gelatinase B; Gene expression; Genes; Glycogen; Glycogen synthase kinase 3; Glycolysis; Heparan sulfate; hMSC; Inhibitors; Kinases; Matrix metalloproteinase; Mesenchyme; Nuclear transport; Regeneration; Signal transduction; Sox9 protein; Stem cells; Tissue engineering; WNT; Wnt protein; tissue engineering; chondrogenesis; WNT; hMSC; cartilage

Mesenchymal stem cells (MSCs) are multipotent cells, mainly from bone marrow, and an ideal source of cells in bone and cartilage tissue engineering. A study of the chondrogenic differentiation of MSCs is of particular interest for MSCs-based cartilage regeneration. In this study, we aimed to optimiz...