The Influence of Cold Atmospheric Pressure Plasma-Treated Media on the Cell Viability, Motility, and Induction of Apoptosis in Human Non-Metastatic (MCF7) and Metastatic (MDA-MB-231) Breast Cancer Cell Lines

Breast cancer remains the most common type of cancer, occurring in middle-aged women, and often leads to patients' death. In this work, we applied a cold atmospheric pressure plasma (CAPP)-based reaction-discharge system, one that is unique in its class, for the production of CAPP-activated med...

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Published inInternational journal of molecular sciences Vol. 22; no. 8; p. 3855
Main Authors Terefinko, Dominik, Dzimitrowicz, Anna, Bielawska-Pohl, Aleksandra, Klimczak, Aleksandra, Pohl, Pawel, Jamroz, Piotr
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.04.2021
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Abstract Breast cancer remains the most common type of cancer, occurring in middle-aged women, and often leads to patients' death. In this work, we applied a cold atmospheric pressure plasma (CAPP)-based reaction-discharge system, one that is unique in its class, for the production of CAPP-activated media (DMEM and Opti-MEM); it is intended for further uses in breast cancer treatment. To reach this aim, different volumes of DMEM or Opti-MEM were treated by CAPP. Prepared media were exposed to the CAPP treatment at seven different time intervals and examined in respect of their impact on cell viability and motility, and the induction of the apoptosis in human non-metastatic (MCF7) and metastatic (MDA-MB-231) breast cancer cell lines. As a control, the influence of CAPP-activated media on the viability and motility, and the type of the cell death of the non-cancerous human normal MCF10A cell line, was estimated. Additionally, qualitative and quantitative analyses of the reactive oxygen and nitrogen species (RONS), generated during the CAPP operation in contact with analyzed media, were performed. Based on the conducted research, it was found that 180 s (media activation time by CAPP) should be considered as the minimal toxic dose, which significantly decreases the cell viability and the migration of MDA-MB-231 cells, and also disturbs life processes of MCF7 cells. Finally, CAPP-activated media led to the apoptosis of analyzed cell lines, especially of the metastatic MDA-MB-231 cell line. Therefore, the application of the CAPP system may be potentially applied as a therapeutic strategy for the management of highly metastatic human breast cancer.
AbstractList Breast cancer remains the most common type of cancer, occurring in middle-aged women, and often leads to patients’ death. In this work, we applied a cold atmospheric pressure plasma (CAPP)-based reaction-discharge system, one that is unique in its class, for the production of CAPP-activated media (DMEM and Opti-MEM); it is intended for further uses in breast cancer treatment. To reach this aim, different volumes of DMEM or Opti-MEM were treated by CAPP. Prepared media were exposed to the CAPP treatment at seven different time intervals and examined in respect of their impact on cell viability and motility, and the induction of the apoptosis in human non-metastatic (MCF7) and metastatic (MDA-MB-231) breast cancer cell lines. As a control, the influence of CAPP-activated media on the viability and motility, and the type of the cell death of the non-cancerous human normal MCF10A cell line, was estimated. Additionally, qualitative and quantitative analyses of the reactive oxygen and nitrogen species (RONS), generated during the CAPP operation in contact with analyzed media, were performed. Based on the conducted research, it was found that 180 s (media activation time by CAPP) should be considered as the minimal toxic dose, which significantly decreases the cell viability and the migration of MDA-MB-231 cells, and also disturbs life processes of MCF7 cells. Finally, CAPP-activated media led to the apoptosis of analyzed cell lines, especially of the metastatic MDA-MB-231 cell line. Therefore, the application of the CAPP system may be potentially applied as a therapeutic strategy for the management of highly metastatic human breast cancer.
Author Pohl, Pawel
Klimczak, Aleksandra
Bielawska-Pohl, Aleksandra
Jamroz, Piotr
Terefinko, Dominik
Dzimitrowicz, Anna
AuthorAffiliation 1 Department of Analytical Chemistry and Chemical Metallurgy, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze St. Wyspianskiego 27, 50-370 Wroclaw, Poland; pawel.pohl@pwr.edu.pl (P.P.); piotr.jamroz@pwr.edu.pl (P.J.)
2 Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland; aleksandra.bielawska-pohl@hirszfeld.pl (A.B.-P.); aleksandra.klimczak@hirszfeld.pl (A.K.)
AuthorAffiliation_xml – name: 2 Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland; aleksandra.bielawska-pohl@hirszfeld.pl (A.B.-P.); aleksandra.klimczak@hirszfeld.pl (A.K.)
– name: 1 Department of Analytical Chemistry and Chemical Metallurgy, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze St. Wyspianskiego 27, 50-370 Wroclaw, Poland; pawel.pohl@pwr.edu.pl (P.P.); piotr.jamroz@pwr.edu.pl (P.J.)
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Keywords breast cancer
biological activity
reactive oxygen and nitrogen species
non-thermal plasma
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Snippet Breast cancer remains the most common type of cancer, occurring in middle-aged women, and often leads to patients' death. In this work, we applied a cold...
Breast cancer remains the most common type of cancer, occurring in middle-aged women, and often leads to patients’ death. In this work, we applied a cold...
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StartPage 3855
SubjectTerms Apoptosis
Atmospheric pressure
biological activity
Breast cancer
Cancer therapies
Cell culture
Cell death
Cell viability
Fever
Hyperthermia
Metastases
Metastasis
Nanoparticles
Nitrates
non-thermal plasma
Oxidative stress
Qualitative analysis
reactive oxygen and nitrogen species
Tumor cell lines
Wound healing
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Title The Influence of Cold Atmospheric Pressure Plasma-Treated Media on the Cell Viability, Motility, and Induction of Apoptosis in Human Non-Metastatic (MCF7) and Metastatic (MDA-MB-231) Breast Cancer Cell Lines
URI https://www.ncbi.nlm.nih.gov/pubmed/33917790
https://www.proquest.com/docview/2548644189
https://pubmed.ncbi.nlm.nih.gov/PMC8068204
https://doaj.org/article/750b0fbfcf5d431ea2251d1a796e0743
Volume 22
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