The Cancer Stem Cell Niche in Ovarian Cancer and Its Impact on Immune Surveillance

• Published in: International journal of molecular sciences Vol. 22; no. 8; p. 4091
• Main Authors: Jain, Srishti, Annett, Stephanie L, Morgan, Maria P, Robson, Tracy
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.04.2021; MDPI
• Subjects: Animals; Ascites; Biomarkers; cancer stem cells; Cancer therapies; Chemoresistance; Chemotherapy; Female; Gynecology; Humans; Hypoxia; immune surveillance; Immunologic Surveillance; Immunosurveillance; Inflammation - pathology; Medical prognosis; Medical screening; Microenvironments; Mortality; Neoplastic Stem Cells - pathology; Ovarian cancer; Ovarian Neoplasms - immunology; Ovarian Neoplasms - pathology; Ovarian Neoplasms - therapy; Review; Signal Transduction; Stem Cell Niche - immunology; Stem cells; Transcription factors; Tumor microenvironment; Tumors; tumour microenvironment; tumour microenvironment; cancer stem cells; ovarian cancer; immune surveillance

Ovarian cancer is an aggressive gynaecological cancer with extremely poor prognosis, due to late diagnosis as well as the development of chemoresistance after first-line therapy. Research advances have found stem-like cells present in ovarian tumours, which exist in a dynamic niche and persist throu...