The Cancer Stem Cell Niche in Ovarian Cancer and Its Impact on Immune Surveillance

Ovarian cancer is an aggressive gynaecological cancer with extremely poor prognosis, due to late diagnosis as well as the development of chemoresistance after first-line therapy. Research advances have found stem-like cells present in ovarian tumours, which exist in a dynamic niche and persist throu...

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Published inInternational journal of molecular sciences Vol. 22; no. 8; p. 4091
Main Authors Jain, Srishti, Annett, Stephanie L, Morgan, Maria P, Robson, Tracy
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 15.04.2021
MDPI
Subjects
Animals
Ascites
Biomarkers
cancer stem cells
Cancer therapies
Chemoresistance
Chemotherapy
Female
Gynecology
Humans
Hypoxia
immune surveillance
Immunologic Surveillance
Immunosurveillance
Inflammation - pathology
Medical prognosis
Medical screening
Microenvironments
Mortality
Neoplastic Stem Cells - pathology
Ovarian cancer
Ovarian Neoplasms - immunology
Ovarian Neoplasms - pathology
Ovarian Neoplasms - therapy
Review
Signal Transduction
Stem Cell Niche - immunology
Stem cells
Transcription factors
Tumor microenvironment
Tumors
tumour microenvironment
tumour microenvironment
cancer stem cells
ovarian cancer
immune surveillance
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Abstract Ovarian cancer is an aggressive gynaecological cancer with extremely poor prognosis, due to late diagnosis as well as the development of chemoresistance after first-line therapy. Research advances have found stem-like cells present in ovarian tumours, which exist in a dynamic niche and persist through therapy. The stem cell niche interacts extensively with the immune and non-immune components of the tumour microenvironment. Significant pathways associated with the cancer stem cell niche have been identified which interfere with the immune component of the tumour microenvironment, leading to immune surveillance evasion, dysfunction and suppression. This review aims to summarise current evidence-based knowledge on the cancer stem cell niche within the ovarian cancer tumour microenvironment and its effect on immune surveillance. Furthermore, the review seeks to understand the clinical consequences of this dynamic interaction by highlighting current therapies which target these processes.
AbstractList Ovarian cancer is an aggressive gynaecological cancer with extremely poor prognosis, due to late diagnosis as well as the development of chemoresistance after first-line therapy. Research advances have found stem-like cells present in ovarian tumours, which exist in a dynamic niche and persist through therapy. The stem cell niche interacts extensively with the immune and non-immune components of the tumour microenvironment. Significant pathways associated with the cancer stem cell niche have been identified which interfere with the immune component of the tumour microenvironment, leading to immune surveillance evasion, dysfunction and suppression. This review aims to summarise current evidence-based knowledge on the cancer stem cell niche within the ovarian cancer tumour microenvironment and its effect on immune surveillance. Furthermore, the review seeks to understand the clinical consequences of this dynamic interaction by highlighting current therapies which target these processes.
Author Robson, Tracy
Jain, Srishti
Annett, Stephanie L
Morgan, Maria P
AuthorAffiliation School of Pharmacy and Biomolecular Science, RCSI University of Medicine and Health Sciences, 123 St Stephen’s Green, D02 YN77 Dublin, Ireland; SrishtiJain@rcsi.ie (S.J.); stephanieannett@rcsi.com (S.L.A.); mmorgan@rcsi.ie (M.P.M.)
AuthorAffiliation_xml – name: School of Pharmacy and Biomolecular Science, RCSI University of Medicine and Health Sciences, 123 St Stephen’s Green, D02 YN77 Dublin, Ireland; SrishtiJain@rcsi.ie (S.J.); stephanieannett@rcsi.com (S.L.A.); mmorgan@rcsi.ie (M.P.M.)
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  givenname: Stephanie L
  surname: Annett
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  orcidid: 0000-0002-7041-3949
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33920983$$D View this record in MEDLINE/PubMed
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2021 by the authors. 2021
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Keywords tumour microenvironment
cancer stem cells
ovarian cancer
immune surveillance
Language English
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Snippet Ovarian cancer is an aggressive gynaecological cancer with extremely poor prognosis, due to late diagnosis as well as the development of chemoresistance after...
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SubjectTerms Animals
Ascites
Biomarkers
cancer stem cells
Cancer therapies
Chemoresistance
Chemotherapy
Female
Gynecology
Humans
Hypoxia
immune surveillance
Immunologic Surveillance
Immunosurveillance
Inflammation - pathology
Medical prognosis
Medical screening
Microenvironments
Mortality
Neoplastic Stem Cells - pathology
Ovarian cancer
Ovarian Neoplasms - immunology
Ovarian Neoplasms - pathology
Ovarian Neoplasms - therapy
Review
Signal Transduction
Stem Cell Niche - immunology
Stem cells
Transcription factors
Tumor microenvironment
Tumors
tumour microenvironment
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Title The Cancer Stem Cell Niche in Ovarian Cancer and Its Impact on Immune Surveillance
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Volume 22
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