Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells - Chen, Shiau-Mei; Hee, Siow-Wey; Chou, Shih-Yun; Liu, Meng-Wei; Chen, Che-Hong; Mochly-Rosen, Daria; Chang, Tien-Jyun; Chuang, Lee-Ming (Biomolecules (Basel, Switzerland), 2021)
Keywords: 4-Hydroxynonenal; Adenosine Triphosphate - genetics; Alda-1; Aldehyde dehydrogenase; aldehyde dehydrogenase 2 (ALDH2); Aldehyde Dehydrogenase, Mitochondrial - genetics; Aldehydes - pharmacology; Animals; Apoptosis; Apoptosis - drug effects; Benzamides - pharmacology; Benzodioxoles - pharmacology; beta cell function; Beta cells; Cell death; Cell Death - drug effects; Cell viability; Dehydrogenases; Disease Models, Animal; Experiments; Fatty acids; Gene expression; glucolipotoxicity; Glucose; Glucose - metabolism; Humans; Hyperglycemia; Hyperlipidemia; Insulin; Insulin resistance; Insulin secretion; Insulin Secretion - genetics; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Intracellular; Lipids; Lipids - genetics; Metabolic Detoxication, Phase I - genetics; Mitochondria; Mitochondria - drug effects; Mitochondria - genetics; Mitochondria - metabolism; Oxidative stress; Oxidative Stress - drug effects; Oxygen consumption; Pancreas; Pyruvaldehyde; Reactive oxygen species; Reactive Oxygen Species - metabolism; Secretion; Sweden; United States--US; Germany; Taiwan; aldehyde dehydrogenase 2 (ALDH2); glucolipotoxicity; beta cell function; Alda-1