Anorexigenic Effects of Intermittent Hypoxia on the Gut-Brain Axis in Sleep Apnea Syndrome

• Published in: International journal of molecular sciences Vol. 23; no. 1; p. 364
• Main Authors: Shobatake, Ryogo, Ota, Hiroyo, Takahashi, Nobuyuki, Ueno, Satoshi, Sugie, Kazuma, Takasawa, Shin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.12.2021; MDPI
• Subjects: Adipocytes; Adipose tissue; Airway management; Amphetamines; Animal models; Animals; Anorexia - pathology; Apnea; Appetite; Attenuation; Beta cells; Binding sites; Body mass index; Brain-Gut Axis; Cocaine; Cocaine- and amphetamine-regulated transcript protein; enteroendocrine cells; Enzymes; Epidemiology; Feeding behavior; Food; Gene expression; Glucagon; Glucagon-like peptide 1; Glucose; Glucose - metabolism; Hepatocytes; Humans; Hypertension; Hypothalamus; Hypoxia; Hypoxia - complications; Hypoxia - genetics; Insulin; Insulin resistance; Insulin secretion; intermittent hypoxia; Molecular modelling; Muscles; Myocytes; neuronal cells; Neurotensin; Obesity; Proopiomelanocortin; Review; Risk factors; Signal transduction; Skeletal muscle; Sleep apnea; sleep apnea syndrome; Sleep Apnea Syndromes - complications; Sleep disorders; Transcription; enteroendocrine cells; neurotensin; cocaine- and amphetamine-regulated transcript; glucagon-like peptide-1; sleep apnea syndrome; neuronal cells; proopiomelanocortin; appetite; peptide YY; intermittent hypoxia

Sleep apnea syndrome (SAS) is a breathing disorder characterized by recurrent episodes of upper-airway collapse, resulting in intermittent hypoxia (IH) during sleep. Experimental studies with animals and cellular models have indicated that IH leads to attenuation of glucose-induced insulin secretion...