Polysialylation in a DISC1 Mutant Mouse

Schizophrenia is a serious psychiatric disorder that affects the social life of patients. Psychiatric disorders are caused by a complex combination of genetic (G) and environmental (E) factors. Polysialylation represents a unique posttranslational modification of a protein, and such changes in neura...

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Published inInternational journal of molecular sciences Vol. 23; no. 9; p. 5207
Main Authors Takahashi, Yuka, Abe, Chikara, Hane, Masaya, Wu, Di, Kitajima, Ken, Sato, Chihiro
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.05.2022
MDPI
Subjects
Amygdala
Bipolar disorder
Brain
Cell adhesion
Cell adhesion molecules
DISC1
Disc1 protein
environmental factor
genetic factor
Mental disorders
Mutants
Mutation
NCAM
Neural cell adhesion molecule
Olfactory bulb
polysialic acid
Polysialylation
Prefrontal cortex
Rodents
Schizophrenia
Suprachiasmatic nucleus
tail suspension test
environmental factor
genetic factor
NCAM
acute stress
polysialic acid
mental disorder
schizophrenia
DISC1
polysialyltransferase
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Abstract Schizophrenia is a serious psychiatric disorder that affects the social life of patients. Psychiatric disorders are caused by a complex combination of genetic (G) and environmental (E) factors. Polysialylation represents a unique posttranslational modification of a protein, and such changes in neural cell adhesion molecules (NCAMs) have been reported in postmortem brains from patients with psychiatric disorders. To understand the G × E effect on polysialylated NCAM expression, in this study, we performed precise measurements of polySia and NCAM using a disrupted-in-schizophrenia 1 (DISC1)-mutant mouse (G), a mouse model of schizophrenia, under acute stress conditions (E). This is the first study to reveal a lower number and smaller length of polySia in the suprachiasmatic nucleus of DISC1 mutants relative to those in wild-type (WT) mice. In addition, an analysis of polySia and NCAM responses to acute stress in five brain regions (olfactory bulb, prefrontal cortex, suprachiasmatic nucleus, amygdala, and hippocampus) revealed that the pattern of changes in these responses in WT mice and DISC1 mutants differed by region. These differences could indicate the vulnerability of DISC1 mutants to stress.
AbstractList Schizophrenia is a serious psychiatric disorder that affects the social life of patients. Psychiatric disorders are caused by a complex combination of genetic (G) and environmental (E) factors. Polysialylation represents a unique posttranslational modification of a protein, and such changes in neural cell adhesion molecules (NCAMs) have been reported in postmortem brains from patients with psychiatric disorders. To understand the G × E effect on polysialylated NCAM expression, in this study, we performed precise measurements of polySia and NCAM using a disrupted-in-schizophrenia 1 (DISC1)-mutant mouse (G), a mouse model of schizophrenia, under acute stress conditions (E). This is the first study to reveal a lower number and smaller length of polySia in the suprachiasmatic nucleus of DISC1 mutants relative to those in wild-type (WT) mice. In addition, an analysis of polySia and NCAM responses to acute stress in five brain regions (olfactory bulb, prefrontal cortex, suprachiasmatic nucleus, amygdala, and hippocampus) revealed that the pattern of changes in these responses in WT mice and DISC1 mutants differed by region. These differences could indicate the vulnerability of DISC1 mutants to stress.
Author Sato, Chihiro
Abe, Chikara
Wu, Di
Kitajima, Ken
Takahashi, Yuka
Hane, Masaya
AuthorAffiliation 1 Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, Japan; takahashi.yuka@i.mbox.nagoya-u.ac.jp (Y.T.); abe.c.nucoop@gmail.com (C.A.); mhane@agr.nagoya-u.ac.jp (M.H.); diwu@agr.nagoya-u.ac.jp (D.W.); kitajima@agr.nagoya-u.ac.jp (K.K.)
3 Integrated Glyco-Biomedical Research Center (iGMED), Institute for Glyco-core Research (iGCORE), Nagoya University, Chikusa, Nagoya 464-8601, Japan
2 Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan
AuthorAffiliation_xml – name: 1 Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, Japan; takahashi.yuka@i.mbox.nagoya-u.ac.jp (Y.T.); abe.c.nucoop@gmail.com (C.A.); mhane@agr.nagoya-u.ac.jp (M.H.); diwu@agr.nagoya-u.ac.jp (D.W.); kitajima@agr.nagoya-u.ac.jp (K.K.)
– name: 2 Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan
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Issue 9
Keywords tail suspension test
environmental factor
genetic factor
NCAM
acute stress
polysialic acid
mental disorder
schizophrenia
DISC1
polysialyltransferase
Language English
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Snippet Schizophrenia is a serious psychiatric disorder that affects the social life of patients. Psychiatric disorders are caused by a complex combination of genetic...
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StartPage 5207
SubjectTerms Amygdala
Bipolar disorder
Brain
Cell adhesion
Cell adhesion molecules
DISC1
Disc1 protein
environmental factor
genetic factor
Mental disorders
Mutants
Mutation
NCAM
Neural cell adhesion molecule
Olfactory bulb
polysialic acid
Polysialylation
Prefrontal cortex
Rodents
Schizophrenia
Suprachiasmatic nucleus
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Title Polysialylation in a DISC1 Mutant Mouse
URI https://www.ncbi.nlm.nih.gov/pubmed/35563598
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