Fingolimod phosphate promotes the neuroprotective effects of microglia

• Published in: Journal of neuroimmunology Vol. 256; no. 1-2; pp. 13 - 18
• Main Authors: Noda, Hiromi, Takeuchi, Hideyuki, Mizuno, Tetsuya, Suzumura, Akio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2013
• Subjects: Allergy and Immunology; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Cells, Cultured; Central Nervous System - cytology; Cytokines - genetics; Cytokines - metabolism; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors - pharmacology; Enzyme-Linked Immunosorbent Assay; Fingolimod; Fingolimod Hydrochloride; Flow Cytometry; Gene Expression Regulation - drug effects; Glial Cell Line-Derived Neurotrophic Factor - genetics; Glial Cell Line-Derived Neurotrophic Factor - metabolism; Lipopolysaccharides - pharmacology; Mice; Mice, Inbred C57BL; Microglia; Microglia - drug effects; Neurology; Neuroprotection; Neuroprotective Agents - pharmacology; Neurotrophic factor; Pro-inflammatory cytokine; Propylene Glycols - pharmacology; Receptors, Lysosphingolipid - genetics; Receptors, Lysosphingolipid - metabolism; RNA, Messenger - metabolism; Sphingosine - analogs & derivatives; Sphingosine - pharmacology; Pro-inflammatory cytokine; Neurotrophic factor; Neuroprotection; Fingolimod; Microglia

Fingolimod phosphate (FTY720) is a sphingosine 1-phosphate (S1P) receptor agonist that is being used as a new oral drug for multiple sclerosis. FTY720 prevents lymphocytes from moving out of the lymphoid organs and inhibits autoreactive lymphocytes from infiltrating the central nervous system. Wheth...