Pulmonary exposure to metallic nanomaterials during pregnancy irreversibly impairs lung development of the offspring
Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of development, are of major importance. The aim of the study was to assess the impact of respiratory exposure to metallic and metal oxide NPs during pr...
Saved in:
Published in | Nanotoxicology Vol. 11; no. 4; pp. 484 - 495 |
---|---|
Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Taylor & Francis
21.04.2017
Taylor & Francis Ltd |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of development, are of major importance. The aim of the study was to assess the impact of respiratory exposure to metallic and metal oxide NPs during pregnancy on lung development of the offspring and to determine the key parameters involved in lung alterations. Pregnant mice were exposed to weekly doses of 100 μg (total dose 300 μg) of titanium dioxide (TiO
2
), cerium oxide (CeO
2
), silver (Ag) NPs or saline solution by nonsurgical intratracheal instillation. The offspring lungs were analyzed at different stages of lung development: fetal stage (gestational day 17.5), pulmonary alveolarization (post-delivery day 14.5) and lung maturity (post-delivery day 49.5). Regardless of the type of NP, maternal exposure during gestation induced long-lasting impairment of lung development of the offspring. This effect was accompanied by: i) decreased placental efficiency together with the presence of NPs in placenta, ii) no increase of inflammatory mediators present in amniotic fluid, placenta or offspring lungs and iii) decreased pulmonary expression of vascular endothelial growth factor-α (VEGF-α) and matrix metalloproteinase 9 (MMP-9) at the fetal stage, and fibroblast growth factor-18 (FGF-18) at the alveolarization stage. Respiratory exposure to metallic NPs during pregnancy induces stereotyped impairment of lung development with a lasting effect in adult mice, independently of the chemical nature of the NP. |
---|---|
AbstractList | Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of development, are of major importance. The aim of the study was to assess the impact of respiratory exposure to metallic and metal oxide NPs during pregnancy on lung development of the offspring and to determine the key parameters involved in lung alterations. Pregnant mice were exposed to weekly doses of 100 μg (total dose 300 μg) of titanium dioxide (TiO2), cerium oxide (CeO2), silver (Ag) NPs or saline solution by nonsurgical intratracheal instillation. The offspring lungs were analyzed at different stages of lung development: fetal stage (gestational day 17.5), pulmonary alveolarization (post-delivery day 14.5) and lung maturity (post-delivery day 49.5). Regardless of the type of NP, maternal exposure during gestation induced long-lasting impairment of lung development of the offspring. This effect was accompanied by: i) decreased placental efficiency together with the presence of NPs in placenta, ii) no increase of inflammatory mediators present in amniotic fluid, placenta or offspring lungs and iii) decreased pulmonary expression of vascular endothelial growth factor-α (VEGF-α) and matrix metalloproteinase 9 (MMP-9) at the fetal stage, and fibroblast growth factor-18 (FGF-18) at the alveolarization stage. Respiratory exposure to metallic NPs during pregnancy induces stereotyped impairment of lung development with a lasting effect in adult mice, independently of the chemical nature of the NP. Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of development, are of major importance. The aim of the study was to assess the impact of respiratory exposure to metallic and metal oxide NPs during pregnancy on lung development of the offspring and to determine the key parameters involved in lung alterations. Pregnant mice were exposed to weekly doses of 100 μg (total dose 300 μg) of titanium dioxide (TiO ), cerium oxide (CeO ), silver (Ag) NPs or saline solution by nonsurgical intratracheal instillation. The offspring lungs were analyzed at different stages of lung development: fetal stage (gestational day 17.5), pulmonary alveolarization (post-delivery day 14.5) and lung maturity (post-delivery day 49.5). Regardless of the type of NP, maternal exposure during gestation induced long-lasting impairment of lung development of the offspring. This effect was accompanied by: i) decreased placental efficiency together with the presence of NPs in placenta, ii) no increase of inflammatory mediators present in amniotic fluid, placenta or offspring lungs and iii) decreased pulmonary expression of vascular endothelial growth factor-α (VEGF-α) and matrix metalloproteinase 9 (MMP-9) at the fetal stage, and fibroblast growth factor-18 (FGF-18) at the alveolarization stage. Respiratory exposure to metallic NPs during pregnancy induces stereotyped impairment of lung development with a lasting effect in adult mice, independently of the chemical nature of the NP. Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of development, are of major importance. The aim of the study was to assess the impact of respiratory exposure to metallic and metal oxide NPs during pregnancy on lung development of the offspring and to determine the key parameters involved in lung alterations. Pregnant mice were exposed to weekly doses of 100 μg (total dose 300 μg) of titanium dioxide (TiO 2 ), cerium oxide (CeO 2 ), silver (Ag) NPs or saline solution by nonsurgical intratracheal instillation. The offspring lungs were analyzed at different stages of lung development: fetal stage (gestational day 17.5), pulmonary alveolarization (post-delivery day 14.5) and lung maturity (post-delivery day 49.5). Regardless of the type of NP, maternal exposure during gestation induced long-lasting impairment of lung development of the offspring. This effect was accompanied by: i) decreased placental efficiency together with the presence of NPs in placenta, ii) no increase of inflammatory mediators present in amniotic fluid, placenta or offspring lungs and iii) decreased pulmonary expression of vascular endothelial growth factor-α (VEGF-α) and matrix metalloproteinase 9 (MMP-9) at the fetal stage, and fibroblast growth factor-18 (FGF-18) at the alveolarization stage. Respiratory exposure to metallic NPs during pregnancy induces stereotyped impairment of lung development with a lasting effect in adult mice, independently of the chemical nature of the NP. |
Author | Boczkowski, Jorge Rose, Jérôme Lanone, Sophie Vantelon, Delphine Delacourt, Christophe Ridoux, Audrey Salome, Murielle Franco-Montoya, Marie-Laure Paineau, Erwan Paul, Emmanuel Hesse, Bernhard Pairon, Jean-Claude Angeletti, Bernard Vibhushan, Shamila Tiendrebeogo, Arnaud Canouï-Poitrine, Florence |
Author_xml | – sequence: 1 givenname: Emmanuel surname: Paul fullname: Paul, Emmanuel organization: Faculté de Médecine, DHU A-TVB, IMRB, Université Paris Est Créteil – sequence: 2 givenname: Marie-Laure surname: Franco-Montoya fullname: Franco-Montoya, Marie-Laure organization: Faculté de Médecine, DHU A-TVB, IMRB, Université Paris Est Créteil – sequence: 3 givenname: Erwan surname: Paineau fullname: Paineau, Erwan organization: Laboratoire de Physique des Solides, CNRS, University of Paris-Sud, Université Paris-Saclay – sequence: 4 givenname: Bernard surname: Angeletti fullname: Angeletti, Bernard organization: CEREGE, Aix Marseille Université-CNRS-IRD-Collège de France – sequence: 5 givenname: Shamila surname: Vibhushan fullname: Vibhushan, Shamila organization: Faculté de Médecine, DHU A-TVB, IMRB, Université Paris Est Créteil – sequence: 6 givenname: Audrey surname: Ridoux fullname: Ridoux, Audrey organization: Faculté de Médecine, DHU A-TVB, IMRB, Université Paris Est Créteil – sequence: 7 givenname: Arnaud surname: Tiendrebeogo fullname: Tiendrebeogo, Arnaud organization: Faculté de Médecine, DHU A-TVB, IMRB, Université Paris Est Créteil – sequence: 8 givenname: Murielle surname: Salome fullname: Salome, Murielle organization: European Synchrotron Radiation Facility – sequence: 9 givenname: Bernhard surname: Hesse fullname: Hesse, Bernhard organization: European Synchrotron Radiation Facility – sequence: 10 givenname: Delphine surname: Vantelon fullname: Vantelon, Delphine organization: Synchrotron SOLEIL – sequence: 11 givenname: Jérôme surname: Rose fullname: Rose, Jérôme organization: CEREGE, Aix Marseille Université-CNRS-IRD-Collège de France – sequence: 12 givenname: Florence surname: Canouï-Poitrine fullname: Canouï-Poitrine, Florence organization: Public Health Department, AP-HP, Henri-Mondor Teaching Hospital – sequence: 13 givenname: Jorge surname: Boczkowski fullname: Boczkowski, Jorge organization: Faculté de Médecine, DHU A-TVB, IMRB, Université Paris Est Créteil – sequence: 14 givenname: Sophie surname: Lanone fullname: Lanone, Sophie organization: Faculté de Médecine, DHU A-TVB, IMRB, Université Paris Est Créteil – sequence: 15 givenname: Christophe surname: Delacourt fullname: Delacourt, Christophe organization: Faculté de Médecine, DHU A-TVB, IMRB, Université Paris Est Créteil – sequence: 16 givenname: Jean-Claude surname: Pairon fullname: Pairon, Jean-Claude email: jc.pairon@chicreteil.fr organization: Centre Hospitalier Intercommunal, Institut Santé-Travail Paris-Est |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28358292$$D View this record in MEDLINE/PubMed https://inserm.hal.science/inserm-03109063$$DView record in HAL |
BookMark | eNp9kctuHCEQRVFkK34kn5AIKVvPuHj0axfLcuxIIyWLZI3o7sLGoqEDtJP5-zCaGS-9KihO3ariXpATHzwS8onBmkEL16yRohIdrDmwZs0EY6Jl78j5Lr-qJMiT47lAZ-QipWeAquY1e0_OeCuqlnf8nOSfi5uC13FL8d8c0hKR5kAnzNo5O1CvfZh0xmi1S3RcovWPdI74WB6GLbUx4gvGZHtXLtOsbUzULYUZS96FeUKfaTA0P2EJJs07gQ_k1BQ5_HiIl-T3t7tftw-rzY_777c3m9VQSZlXnJuu6XCUgy7bCT3yUXMwom3QVCiGoZeITTu0GtpGd6Zueg19zbTGRvaVFJfkaq_7pJ0qnaeypgraqoebjbI-YZwUCAYd1OKFFfzLHp9j-LNgyuo5LNGXCRXrQLbQAPBCVXtqiCGliOZVmYHaWaOO1qidNepgTan7fFBf-gnH16qjFwX4ugesNyFO-m-IblRZb12IJpbvtkmJt3v8B7Ruog8 |
CitedBy_id | crossref_primary_10_1016_j_envint_2023_108015 crossref_primary_10_1039_D1CS00574J crossref_primary_10_1016_j_jhazmat_2020_122033 crossref_primary_10_1039_C7JA00402H crossref_primary_10_1016_j_ese_2023_100325 crossref_primary_10_1021_acs_chemrestox_8b00177 crossref_primary_10_1186_s12989_020_00359_x crossref_primary_10_1016_j_ecoenv_2023_114755 crossref_primary_10_3390_nano10020259 crossref_primary_10_1016_j_matdes_2021_109611 crossref_primary_10_1016_j_envres_2024_119165 crossref_primary_10_1016_j_jtemb_2020_126477 crossref_primary_10_1016_j_cbi_2018_09_015 crossref_primary_10_1186_s12199_021_00995_5 crossref_primary_10_1186_s12951_018_0406_6 crossref_primary_10_1152_ajplung_00369_2019 crossref_primary_10_1186_s12989_021_00398_y crossref_primary_10_1080_17425255_2018_1397131 crossref_primary_10_1039_C8BM00856F crossref_primary_10_3390_nano10071309 crossref_primary_10_1007_s10311_024_01709_3 crossref_primary_10_1021_acs_analchem_0c02416 crossref_primary_10_1016_j_biopha_2019_109125 crossref_primary_10_1039_C8NR02096E crossref_primary_10_1039_D1EN01126J crossref_primary_10_1016_j_biopha_2019_109148 crossref_primary_10_1038_s41390_019_0657_4 crossref_primary_10_1088_2053_1583_aab9e2 crossref_primary_10_1186_s12989_022_00497_4 crossref_primary_10_1016_j_ecoenv_2020_110911 crossref_primary_10_1002_advs_202401060 crossref_primary_10_1016_j_chemosphere_2018_05_058 crossref_primary_10_1016_j_taap_2022_116056 crossref_primary_10_1016_S2588_932X_23_00150_X crossref_primary_10_3390_ijms222212266 crossref_primary_10_1016_j_jhazmat_2019_121830 crossref_primary_10_1186_s11671_023_03927_0 crossref_primary_10_1002_xrs_2994 crossref_primary_10_1016_j_colsurfb_2017_11_049 crossref_primary_10_3390_nano11030791 |
Cites_doi | 10.1111/j.1439-0531.2012.02147.x 10.1056/NEJMra067279 10.1183/09031936.00127107 10.3109/08958378.2011.562567 10.3762/bjnano.4.105 10.1289/EHP54 10.1186/s40199-016-0162-9 10.1038/srep04352 10.1136/thx.37.8.580 10.1152/ajplung.00013.2012 10.1053/j.sempedsurg.2015.01.011 10.1111/j.1365-2796.2009.02187.x 10.1107/S0909049510010691 10.1107/S0909049505012719 10.1289/ehp.0800511 10.1039/C3NR05479A 10.1371/journal.pone.0119726 10.1039/C4CC01251H 10.1016/j.ajog.2016.01.181 10.1021/es3035347 10.1152/ajplung.00140.2001 10.1016/j.sab.2006.12.002 10.1203/01.PDR.0000106314.99930.65 10.1100/tsw.2011.67 10.1038/nnano.2011.41 10.3109/17435390.2015.1107143 10.1016/j.siny.2008.08.011 10.1016/j.taap.2012.05.005 10.1016/j.taap.2011.09.027 10.1107/S1600577516000746 10.1186/1743-8977-10-15 10.1038/nnano.2014.62 10.1152/ajplung.00294.2011 10.1016/j.jcis.2015.04.015 10.1177/0960327110363329 10.1016/j.trac.2010.08.008 10.1186/1743-8977-7-16 10.1016/j.envpol.2010.02.012 10.3390/ijerph110605720 10.1186/1743-8977-3-4 10.1164/rccm.201302-0323OC 10.1152/ajplung.2000.279.3.L600 10.1053/j.semperi.2007.11.003 10.1088/0026-1394/50/6/663 10.1038/nnano.2010.12 10.1186/s12989-016-0151-7 10.1186/1743-8977-6-20 10.1080/17435390.2016.1242797 10.3109/17435390.2015.1104740 10.1136/adc.35.184.544 10.1016/j.toxlet.2011.05.1027 |
ContentType | Journal Article |
Copyright | 2017 Informa UK Limited, trading as Taylor & Francis Group 2017 2017 Informa UK Limited, trading as Taylor & Francis Group Distributed under a Creative Commons Attribution 4.0 International License |
Copyright_xml | – notice: 2017 Informa UK Limited, trading as Taylor & Francis Group 2017 – notice: 2017 Informa UK Limited, trading as Taylor & Francis Group – notice: Distributed under a Creative Commons Attribution 4.0 International License |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 1XC VOOES |
DOI | 10.1080/17435390.2017.1311381 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1743-5404 |
EndPage | 495 |
ExternalDocumentID | oai_HAL_inserm_03109063v1 10_1080_17435390_2017_1311381 28358292 1311381 |
Genre | Original Article Journal Article |
GrantInformation_xml | – fundername: Agence Nationale de la Recherche grantid: ANR-11-IDEX-0001-02,ANR-11-LABX-0064 |
GroupedDBID | --- 00X 0BK 0R~ 123 4.4 53G AAJNR AALUX AAMIU AAPUL AAQRR ABBKH ABDBF ABEIZ ABLKL ABPTK ABUPF ACENM ACFUF ACGEJ ACLSK ACPRK ADCVX ADFCX ADXPE AECIN AENEX AEOZL AEYQI AFRAH AFWLO AGDLA AGFJD AGRBW AGYJP AIJEM AIRBT AKBVH ALIIL ALMA_UNASSIGNED_HOLDINGS ALQZU BABNJ BLEHA BOHLJ CCCUG CS3 DKSSO DU5 EBD EBS EJD EMOBN ESX F5P H13 HZ~ J.N KRBQP KSSTO KWAYT KYCEM M4Z MM. O9- P2P RNANH RVRKI SV3 TFL TFW TUS UHWXJ V1S ~1N 5VS ABJNI ABLIJ ABXYU ACIEZ AFFVI ALYBC AWYRJ CGR CUY CVF ECM EIF LJTGL M44 NPM S70 TBQAZ TDBHL TERGH TUROJ AAYXX CITATION 1XC VOOES |
ID | FETCH-LOGICAL-c544t-22f979ed4ca1133ad2da20f387ef5e3ccb4ee78c8a087a9f67ba0b61aae74b543 |
ISSN | 1743-5390 |
IngestDate | Tue Oct 15 15:58:19 EDT 2024 Thu Oct 10 21:54:16 EDT 2024 Fri Aug 23 00:36:01 EDT 2024 Tue Oct 15 23:55:38 EDT 2024 Tue Jun 13 19:26:10 EDT 2023 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | Nanoparticles toxicology lung development pregnancy |
Language | English |
License | Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c544t-22f979ed4ca1133ad2da20f387ef5e3ccb4ee78c8a087a9f67ba0b61aae74b543 |
ORCID | 0000-0002-6776-7201 0000-0002-4323-6406 0000-0003-4861-4098 0000-0003-2509-8799 0000-0003-3071-8147 0000-0002-0007-7150 |
OpenAccessLink | https://inserm.hal.science/inserm-03109063 |
PMID | 28358292 |
PQID | 1904807002 |
PQPubID | 2043362 |
PageCount | 12 |
ParticipantIDs | informaworld_taylorfrancis_310_1080_17435390_2017_1311381 hal_primary_oai_HAL_inserm_03109063v1 proquest_journals_1904807002 crossref_primary_10_1080_17435390_2017_1311381 pubmed_primary_28358292 |
PublicationCentury | 2000 |
PublicationDate | 2017-04-21 |
PublicationDateYYYYMMDD | 2017-04-21 |
PublicationDate_xml | – month: 04 year: 2017 text: 2017-04-21 day: 21 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England – name: Abingdon |
PublicationTitle | Nanotoxicology |
PublicationTitleAlternate | Nanotoxicology |
PublicationYear | 2017 |
Publisher | Taylor & Francis Taylor & Francis Ltd |
Publisher_xml | – name: Taylor & Francis – name: Taylor & Francis Ltd |
References | CIT0030 CIT0032 CIT0031 CIT0034 CIT0033 CIT0036 CIT0038 CIT0037 CIT0039 CIT0041 CIT0040 Hay WN (CIT0048) 2001; 2 CIT0043 CIT0042 CIT0001 CIT0045 CIT0044 CIT0003 CIT0002 CIT0046 CIT0005 CIT0049 CIT0004 CIT0007 CIT0009 CIT0050 CIT0052 CIT0051 CIT0010 CIT0054 CIT0053 CIT0012 CIT0011 CIT0055 CIT0014 CIT0013 CIT0016 CIT0015 CIT0018 CIT0017 CIT0019 Weibel ER. (CIT0047) 1966; 24 CIT0021 CIT0020 CIT0023 CIT0022 CIT0025 CIT0024 CIT0027 CIT0026 CIT0029 CIT0028 Drummond D (CIT0008) 2017; 125 |
References_xml | – ident: CIT0046 doi: 10.1111/j.1439-0531.2012.02147.x – volume: 2 start-page: 129 year: 2001 ident: CIT0048 publication-title: Neo Reviews contributor: fullname: Hay WN – ident: CIT0003 doi: 10.1056/NEJMra067279 – ident: CIT0049 doi: 10.1183/09031936.00127107 – ident: CIT0017 doi: 10.3109/08958378.2011.562567 – ident: CIT0011 doi: 10.3762/bjnano.4.105 – volume: 125 start-page: 392 year: 2017 ident: CIT0008 publication-title: Environ Health Perspect doi: 10.1289/EHP54 contributor: fullname: Drummond D – ident: CIT0005 doi: 10.1186/s40199-016-0162-9 – ident: CIT0028 doi: 10.1038/srep04352 – volume: 24 start-page: C56 year: 1966 ident: CIT0047 publication-title: Helv Physiol Pharmacol Acta contributor: fullname: Weibel ER. – ident: CIT0007 doi: 10.1136/thx.37.8.580 – ident: CIT0001 doi: 10.1152/ajplung.00013.2012 – ident: CIT0023 doi: 10.1053/j.sempedsurg.2015.01.011 – ident: CIT0024 doi: 10.1111/j.1365-2796.2009.02187.x – ident: CIT0042 doi: 10.1107/S0909049510010691 – ident: CIT0029 doi: 10.1107/S0909049505012719 – ident: CIT0050 doi: 10.1289/ehp.0800511 – ident: CIT0036 doi: 10.1039/C3NR05479A – ident: CIT0034 doi: 10.1371/journal.pone.0119726 – ident: CIT0025 doi: 10.1039/C4CC01251H – ident: CIT0016 doi: 10.1016/j.ajog.2016.01.181 – ident: CIT0054 doi: 10.1021/es3035347 – ident: CIT0010 doi: 10.1152/ajplung.00140.2001 – ident: CIT0040 doi: 10.1016/j.sab.2006.12.002 – ident: CIT0020 doi: 10.1203/01.PDR.0000106314.99930.65 – ident: CIT0031 doi: 10.1100/tsw.2011.67 – ident: CIT0051 doi: 10.1038/nnano.2011.41 – ident: CIT0002 doi: 10.3109/17435390.2015.1107143 – ident: CIT0015 doi: 10.1016/j.siny.2008.08.011 – ident: CIT0019 doi: 10.1016/j.taap.2012.05.005 – ident: CIT0026 doi: 10.1016/j.taap.2011.09.027 – ident: CIT0045 doi: 10.1107/S1600577516000746 – ident: CIT0037 doi: 10.1186/1743-8977-10-15 – ident: CIT0039 doi: 10.1038/nnano.2014.62 – ident: CIT0043 doi: 10.1152/ajplung.00294.2011 – ident: CIT0018 doi: 10.1016/j.jcis.2015.04.015 – ident: CIT0032 doi: 10.1177/0960327110363329 – ident: CIT0052 doi: 10.1016/j.trac.2010.08.008 – ident: CIT0013 doi: 10.1186/1743-8977-7-16 – ident: CIT0053 doi: 10.1016/j.envpol.2010.02.012 – ident: CIT0021 doi: 10.3390/ijerph110605720 – ident: CIT0033 doi: 10.1186/1743-8977-3-4 – ident: CIT0012 doi: 10.1164/rccm.201302-0323OC – ident: CIT0014 doi: 10.1152/ajplung.2000.279.3.L600 – ident: CIT0030 doi: 10.1053/j.semperi.2007.11.003 – ident: CIT0055 doi: 10.1088/0026-1394/50/6/663 – ident: CIT0004 doi: 10.1038/nnano.2010.12 – ident: CIT0044 doi: 10.1186/s12989-016-0151-7 – ident: CIT0038 doi: 10.1186/1743-8977-6-20 – ident: CIT0027 doi: 10.1080/17435390.2016.1242797 – ident: CIT0022 doi: 10.3109/17435390.2015.1104740 – ident: CIT0009 doi: 10.1136/adc.35.184.544 – ident: CIT0041 doi: 10.1016/j.toxlet.2011.05.1027 |
SSID | ssj0056261 |
Score | 2.3935108 |
Snippet | Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of... |
SourceID | hal proquest crossref pubmed informaworld |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 484 |
SubjectTerms | Air Pollutants - pharmacokinetics Air Pollutants - toxicity Amniotic fluid Animals Biocompatibility Cerium Cerium - toxicity Cerium oxides Developmental stages Dioxides Efficiency Exposure Female Fetuses Fibroblast growth factor 18 Fibroblast Growth Factors - metabolism Gelatinase B Gestation Growth factors Human health and pathology Impairment Inflammation Inhalation Exposure - adverse effects Life Sciences Lung - drug effects Lung - embryology Lung - metabolism lung development Lungs Male Maternal Exposure - adverse effects Matrix metalloproteinase Maturity Metal Nanoparticles - toxicity Metalloproteinase Metals Mice Mice, Inbred C57BL Nanomaterials Nanoparticles Nanotechnology Offspring Organogenesis - drug effects Placenta Placenta - drug effects Placenta - metabolism Pregnancy Prenatal Exposure Delayed Effects - chemically induced Pulmonology and respiratory tract Rodents Saline solutions Silver Silver - metabolism Surgical implants Titanium - toxicity Titanium dioxide Toxicity testing toxicology Trachea Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism |
Title | Pulmonary exposure to metallic nanomaterials during pregnancy irreversibly impairs lung development of the offspring |
URI | https://www.tandfonline.com/doi/abs/10.1080/17435390.2017.1311381 https://www.ncbi.nlm.nih.gov/pubmed/28358292 https://www.proquest.com/docview/1904807002 https://inserm.hal.science/inserm-03109063 |
Volume | 11 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9owELZY9tJL1Xdpt5UP7V52Q0PikPgI7SJUsVsOQdqb5QS7RYIEQWiX_pj-1s7EeaHdPi8RsuKHMp_Hn83MZ0LeoEJ7D2isFQdzZbEINihcccdSUWxLWB80dzA5-fKqP56xj9fedav1oxG1tMuibvz9zryS_7EqlIFdMUv2HyxbNQoF8BvsC0-wMDz_ysbT3RL6yvNpb9YpnvUhlVwpINSoXZ3IJAVCakZSJiSuN-ozimzszxYblG_awJxY7vNsycVme7aEyV9mUpVxAshNU63NX7hNNguuOc3Sm0V8cDaPwYa5i12tZLJTVQhHfodHal2iYsJeFolCC2VharaqKwPtlTvjor_V0B1g8K3KTPDBEA8xjRpAeWIBq6DNLKc-sQhvXR7SiGBCH4yqqZ5rbhHtqkYZMzcVV4671wAoa3hhI496e3Uw4ZTYFjaPcX1-F-WGXHNrzKEa99UnMZpNJiK8uA6PyLHjc89rk-PB8MNwVK71QB6NIm855DJHLLDf3dnNAfs5-pLH3jYVcn-9z8n5TviA3C82KnRgUPeQtFTyiJxOjdL5_pyGdeLe9pye0mmtgb5_TLIKmrSEJs1SWkKTHkCTGmjSCpq0CU1aQJMiNGkDmjTVFKBJK2g-IbPRRfh-bBUXfFixx1hmOY7mPldzFkv4Oq6cO3Pp2NoNfKU95cZxxJTygziQduBLrvt-JO2o35NS-SzymPuUtJM0Uc8Jjewo6M_5PLC5Zr52pGJQndsa1YyAFHdIt_zwYm10XESvkMctLSXQUqKwVIe8BfNU76IK-3gwEYsE_MdK5IK6wO6_wnu8aUCR5ejWBtjC_UMfJ6W1ReFWtgIYOso8AFPpkGcGAdUoUBwxcLjz4vcVX5J79bw7Ie1ss1OvgDtn0esCwD8B7u3HlA |
link.rule.ids | 230,315,786,790,891,27955,27956 |
linkProvider | EBSCOhost |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pulmonary+exposure+to+metallic+nanomaterials+during+pregnancy+irreversibly+impairs+lung+development+of+the+offspring&rft.jtitle=Nanotoxicology&rft.au=Paul%2C+Emmanuel&rft.au=Franco-Montoya%2C+Marie-Laure&rft.au=Paineau%2C+Erwan&rft.au=Angeletti%2C+Bernard&rft.date=2017-04-21&rft.pub=Taylor+%26+Francis+Ltd&rft.issn=1743-5390&rft.eissn=1743-5404&rft.volume=11&rft.issue=4&rft.spage=484&rft_id=info:doi/10.1080%2F17435390.2017.1311381&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1743-5390&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1743-5390&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1743-5390&client=summon |