Folic acid handling by the human gut: implications for food fortification and supplementation

• Published in: The American journal of clinical nutrition Vol. 100; no. 2; pp. 593 - 599
• Main Authors: Patanwala, Imran, King, Maria J, Barrett, David A, Rose, John, Jackson, Ralph, Hudson, Mark, Philo, Mark, Dainty, Jack R, Wright, Anthony JA, Finglas, Paul M, Jones, David E
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Nutrition 01.08.2014; American Society for Clinical Nutrition, Inc; American Society for Nutrition
• Subjects: absorbed dose; administered dose; Administration, Oral; Adult; Biotransformation; blood; Carbon Radioisotopes; chronic exposure; clinical nutrition; Cohort Studies; Cross-Over Studies; Dietary Supplements; dihydrofolate reductase; Female; Folic Acid - administration & dosage; Folic Acid - blood; Folic Acid - metabolism; food fortification; Food, Fortified; Humans; ingestion; intestinal mucosa; Intestinal Mucosa - metabolism; Kinetics; Leucovorin - administration & dosage; Leucovorin - blood; Leucovorin - metabolism; Liver; Male; Methylation; Middle Aged; Nutrition; Portal Vein; Portasystemic Shunt, Transjugular Intrahepatic; rodents; Tetrahydrofolates - blood; Tetrahydrofolates - metabolism; tetrahydrofolic acid; Vitamin B; Vitamins, Minerals, and Phytochemicals

Background: Current thinking, which is based mainly on rodent studies, is that physiologic doses of folic acid (pterylmonoglutamic acid), such as dietary vitamin folates, are biotransformed in the intestinal mucosa and transferred to the portal vein as the natural circulating plasma folate, 5-methyl...