CXCR4 promotes migration, invasion, and epithelial-mesenchymal transition of papillary thyroid carcinoma by activating STAT3 signaling pathway

• Published in: Journal of cancer research and therapeutics Vol. 20; no. 4; pp. 1241 - 1250
• Main Authors: Hu, Yajie, Xu, Zhipeng, Zhou, Dongsheng, Hou, Haitao, Liu, Bin, Long, Houlong, Hu, Wenxin, Tang, Yuanqi, Wang, Jianning, Wei, Dan, Zhao, Quanlin
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.08.2024; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd
• Edition: 2
• Subjects: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Development and progression; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Lung cancer; Male; Metastasis; Mice; Middle Aged; Neoplasm Invasiveness; Original Article; Receptors, CXCR4 - genetics; Receptors, CXCR4 - metabolism; Signal Transduction; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Thyroid cancer; Thyroid Cancer, Papillary - genetics; Thyroid Cancer, Papillary - metabolism; Thyroid Cancer, Papillary - pathology; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology; Xenograft Model Antitumor Assays; China; migration; CXCR4; invasion; papillary thyroid cancer; STAT3

ABSTRACT Aims: Papillary thyroid cancer (PTC) is a serious threat to human health worldwide, while metastasis in the early phase limits therapeutic success and leads to poor survival outcomes. The CXC chemokine receptor type 4 (CXCR4) plays an important role in many cellular movements such as transc...