Impact of renal function on eligibility for chemotherapy and survival in patients who have undergone radical nephro‐ureterectomy

• Published in: BJU international Vol. 112; no. 4; pp. 453 - 461
• Main Authors: Xylinas, Evanguelos, Rink, Michael, Margulis, Vitaly, Clozel, Thomas, Lee, Richard K., Comploj, Evi, Novara, Giacomo, Raman, Jay D., Lotan, Yair, Weizer, Alon, Roupret, Morgan, Pycha, Armin, Scherr, Douglas S., Seitz, Christian, Ficarra, Vincenzo, Trinh, Quoc‐Dien, Karakiewicz, Pierre I., Montorsi, Francesco, Zerbib, Marc, Shariat, Shahrokh F.
• Format: Journal Article
• Language: English
• Published: Oxford Wiley-Blackwell 01.08.2013; Wiley Subscription Services, Inc
• Subjects: Aged; Biological and medical sciences; Carcinoma, Transitional Cell - drug therapy; Carcinoma, Transitional Cell - mortality; Carcinoma, Transitional Cell - physiopathology; Carcinoma, Transitional Cell - surgery; Chemotherapy; Female; Glomerular Filtration Rate; Humans; Kidney Function Tests; Kidney Neoplasms - drug therapy; Kidney Neoplasms - mortality; Kidney Neoplasms - physiopathology; Kidney Neoplasms - surgery; Male; Medical sciences; Middle Aged; Mortality; Nephrectomy - methods; Nephrology. Urinary tract diseases; Patient Selection; radical nephroureterectomy; renal function; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Survival Rate; Tumors of the urinary system; upper tract urothelial carcinoma; Ureter - surgery; Urinary tract. Prostate gland; Antineoplastic agent; Human; Nephrology; Urinary system disease; Renal function; Prognosis; Nephroureterectomy; upper tract urothelial carcinoma; Urinary tract disease; Malignant tumor; Upper urinary tract transitional cell carcinoma; Survival; Cisplatin; Urology; Glomerular filtration rate; Alkylating agent; Chemotherapy; Treatment; Surgery; radical nephroureterectomy; Cancer; Platinum II Complexes; renal function; chemotherapy
• ISSN: 1464-4096; 1464-410X; 1464-410X
• DOI: 10.1111/j.1464-410X.2012.11649.x

What's known on the subject? and What does the study add? Radical nephroureterectomy (RNU), the standard of care treatment for high‐risk urothelial carcinoma of the upper tract (UTUC), results in loss of a renal unit. Loss of renal function decreases eligibility for systemic chemotherapies and...